The microcephaly ASPM gene is expressed in proliferating tissues and encodes for a mitotic spindle protein
about
Normal variants of Microcephalin and ASPM do not account for brain size variabilityMutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal cortical architectureHuman ASPM participates in spindle organisation, spindle orientation and cytokinesis.Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cellsAutosomal Recessive Primary Microcephaly (MCPH): clinical manifestations, genetic heterogeneity and mutation continuumAllelic diversity in human developmental neurogenetics: insights into biology and diseaseCep120 and TACCs control interkinetic nuclear migration and the neural progenitor pool.Current status and perspectives in atomic force microscopy-based identification of cellular transformationHepatitis C Virus NS5A Protein Down-regulates the Expression of Spindle Gene Aspm through PKR-p38 Signaling PathwayGene organization, evolution and expression of the microtubule-associated protein ASAP (MAP9)ASPM regulates Wnt signaling pathway activity in the developing brainThe microtubule-associated protein ASPM regulates spindle assembly and meiotic progression in mouse oocytesMutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germlineASPM and the evolution of cerebral cortical size in a community of New World monkeysPotential mechanisms of Zika-linked microcephalyDifferential regulation of centrosome integrity by DNA damage response proteins.Microcephaly models in the developing zebrafish retinal neuroepithelium point to an underlying defect in metaphase progression.Genetic, physiologic and ecogeographic factors contributing to variation in Homo sapiens: Homo floresiensis reconsidered.Positive selection on the nonhomologous end-joining factor Cernunnos-XLF in the human lineagePreviously described sequence variant in CDK5RAP2 gene in a Pakistani family with autosomal recessive primary microcephaly.A genome-wide RNAi screen to dissect centriole duplication and centrosome maturation in Drosophila.Deregulation of microcephalin and ASPM expression are correlated with epithelial ovarian cancer progression.ASPM-associated stem cell proliferation is involved in malignant progression of gliomas and constitutes an attractive therapeutic targetCell-autonomous beta-catenin signaling regulates cortical precursor proliferationAngelman syndrome protein UBE3A interacts with primary microcephaly protein ASPM, localizes to centrosomes and regulates chromosome segregationSmall organelle, big responsibility: the role of centrosomes in development and disease.Mutations in centrosomal protein CEP152 in primary microcephaly families linked to MCPH4.Genome resequencing and bioinformatic analysis of SNP containing candidate genes in the autoimmune vitiligo Smyth line chicken model.Cep120 is asymmetrically localized to the daughter centriole and is essential for centriole assembly.OSVZ progenitors in the human cortex: an updated perspective on neurodevelopmental disease.Molecular characterization of an intact p53 pathway subtype in high-grade serous ovarian cancer.ASPM and microcephalin expression in epithelial ovarian cancer correlates with tumour grade and survivalThe centrosome and its duplication cycleAnalysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular targetBioXpress: an integrated RNA-seq-derived gene expression database for pan-cancer analysis.Highly efficient CRISPR/Cas9-mediated TAR cloning of genes and chromosomal loci from complex genomes in yeast.Molecular genetics of human primary microcephaly: an overview.Genome-wide analysis of the oxyntic proliferative isthmus zone reveals ASPM as a possible gastric stem/progenitor cell marker over-expressed in cancer.Characterizing PCDH19 in human induced pluripotent stem cells (iPSCs) and iPSC-derived developing neurons: emerging role of a protein involved in controlling polarity during neurogenesis.Mitotic spindle (DIS)orientation and DISease: cause or consequence?
P2860
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P2860
The microcephaly ASPM gene is expressed in proliferating tissues and encodes for a mitotic spindle protein
description
2005 nî lūn-bûn
@nan
2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
The microcephaly ASPM gene is ...... for a mitotic spindle protein
@ast
The microcephaly ASPM gene is ...... for a mitotic spindle protein
@en
The microcephaly ASPM gene is ...... for a mitotic spindle protein
@en-gb
The microcephaly ASPM gene is ...... for a mitotic spindle protein
@nl
type
label
The microcephaly ASPM gene is ...... for a mitotic spindle protein
@ast
The microcephaly ASPM gene is ...... for a mitotic spindle protein
@en
The microcephaly ASPM gene is ...... for a mitotic spindle protein
@en-gb
The microcephaly ASPM gene is ...... for a mitotic spindle protein
@nl
prefLabel
The microcephaly ASPM gene is ...... for a mitotic spindle protein
@ast
The microcephaly ASPM gene is ...... for a mitotic spindle protein
@en
The microcephaly ASPM gene is ...... for a mitotic spindle protein
@en-gb
The microcephaly ASPM gene is ...... for a mitotic spindle protein
@nl
P2093
P3181
P356
P1476
The microcephaly ASPM gene is ...... for a mitotic spindle protein
@en
P2093
Adam Pavlicek
Christopher A Walsh
Ganeshwaran H Mochida
Greg Solomon
Hiroshi Masumoto
J Carl Barrett
John I Risinger
Jun-Ichirou Ohzeki
Jung-Hyun Kim
Megumi Nakano
P304
P3181
P356
10.1093/HMG/DDI220
P407
P50
P577
2005-08-01T00:00:00Z