SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability
about
The histone deacetylase SIRT2 stabilizes Myc oncoproteinsSirtuin functions and modulation: from chemistry to the clinicInterplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogrammingFrom sirtuin biology to human diseases: an updateSirtuins in epigenetic regulationHigh SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinomaTherapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma.Emerging Roles of SIRT1 in Cancer Drug ResistanceRejuvenating sirtuins: the rise of a new family of cancer drug targetsEnterocyte-specific inactivation of SIRT1 reduces tumor load in the APC(+/min) mouse model.Expression of SIRT1 and DBC1 is associated with poor prognosis of soft tissue sarcomas.The histone demethylase JMJD1A induces cell migration and invasion by up-regulating the expression of the long noncoding RNA MALAT1SIRT1 promotes proliferation and inhibits the senescence-like phenotype in human melanoma cells.MYC interacts with the human STAGA coactivator complex via multivalent contacts with the GCN5 and TRRAP subunits.The prenatal origins of cancerHistone deacetylase 2 and N-Myc reduce p53 protein phosphorylation at serine 46 by repressing gene transcription of tumor protein 53-induced nuclear protein 1Identification of a novel polyprenylated acylphloroglucinol‑derived SIRT1 inhibitor with cancer‑specific anti-proliferative and invasion-suppressing activities.Sorting out functions of sirtuins in cancerSIRT1 activation by a c-MYC oncogenic network promotes the maintenance and drug resistance of human FLT3-ITD acute myeloid leukemia stem cells.SIRT1 inactivation evokes antitumor activities in NSCLC through the tumor suppressor p27.Quantitative phosphoproteomic analysis identifies activation of the RET and IGF-1R/IR signaling pathways in neuroblastoma.The novel long noncoding RNA linc00467 promotes cell survival but is down-regulated by N-MycAn unexpected role for caspase-2 in neuroblastoma.An evaluation of small-molecule p53 activators as chemoprotectants ameliorating adverse effects of anticancer drugs in normal cells.The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastomaJanus-faced role of SIRT1 in tumorigenesis.Redefining functional MYCN gene signatures in neuroblastoma.Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6.Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer.SIRT1 is a Highly Networked Protein That Mediates the Adaptation to Chronic Physiological Stress.Insulin receptor phosphorylation by endogenous insulin or the insulin analog AspB10 promotes mammary tumor growth independent of the IGF-I receptor.Neuroblastoma and MYCNThe emerging and diverse roles of sirtuins in cancer: a clinical perspective.Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activitySirtuin 1 (SIRT1): the misunderstood HDAC.MYCN-mediated transcriptional repression in neuroblastoma: the other side of the coin.The diversity of histone versus nonhistone sirtuin substrates.The p53/miR-34 axis in development and disease.Sirtuin inhibitors as anticancer agents.The p53/microRNA connection in gastrointestinal cancer.
P2860
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P2860
SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
SIRT1 promotes N-Myc oncogenes ...... ERK on N-Myc protein stability
@ast
SIRT1 promotes N-Myc oncogenes ...... ERK on N-Myc protein stability
@en
SIRT1 promotes N-Myc oncogenes ...... ERK on N-Myc protein stability
@en-gb
SIRT1 promotes N-Myc oncogenes ...... ERK on N-Myc protein stability
@nl
type
label
SIRT1 promotes N-Myc oncogenes ...... ERK on N-Myc protein stability
@ast
SIRT1 promotes N-Myc oncogenes ...... ERK on N-Myc protein stability
@en
SIRT1 promotes N-Myc oncogenes ...... ERK on N-Myc protein stability
@en-gb
SIRT1 promotes N-Myc oncogenes ...... ERK on N-Myc protein stability
@nl
prefLabel
SIRT1 promotes N-Myc oncogenes ...... ERK on N-Myc protein stability
@ast
SIRT1 promotes N-Myc oncogenes ...... ERK on N-Myc protein stability
@en
SIRT1 promotes N-Myc oncogenes ...... ERK on N-Myc protein stability
@en-gb
SIRT1 promotes N-Myc oncogenes ...... ERK on N-Myc protein stability
@nl
P2093
P2860
P3181
P1433
P1476
SIRT1 promotes N-Myc oncogenes ...... ERK on N-Myc protein stability
@en
P2093
Andrew V Biankin
Antonio Bedalov
Christopher J Scarlett
Emanuele Valli
Eric Sekyere
Giovanni Perini
Glenn M Marshall
Kacper Jankowski
Karen L Mackenzie
P2860
P304
P3181
P356
10.1371/JOURNAL.PGEN.1002135
P407
P577
2011-06-01T00:00:00Z