Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
about
High incidence of somatic BAP1 alterations in sporadic malignant mesotheliomaASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repressionRecognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complexBAP1 is phosphorylated at serine 592 in S-phase following DNA damageGermline mutations in BAP1 predispose to melanocytic tumorsAn emerging model for BAP1's role in regulating cell cycle progressionFrequent mutation of BAP1 in metastasizing uveal melanomasHistone deacetylase inhibitors induce growth arrest and differentiation in uveal melanomaThe ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expressionDUBbing Cancer: Deubiquitylating Enzymes Involved in Epigenetics, DNA Damage and the Cell Cycle As Therapeutic TargetsDrosophila as a Potential Model for Ocular TumorsSubstrate specificity of the ubiquitin and Ubl proteasesRole of Deubiquitinating Enzymes in DNA RepairUpcoming translational challenges for uveal melanomaFine-tuning the ubiquitin code at DNA double-strand breaks: deubiquitinating enzymes at workDeubiquitinating enzymes in cellular signaling and disease regulationPolycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic ImplicationsRecent developments in prognostic and predictive testing in uveal melanomaConnections between TET proteins and aberrant DNA modification in cancerMetastatic uveal melanoma: biology and emerging treatmentsStructure of an atypical Tudor domain in theDrosophilaPolycomblike proteinA Role for Intersubunit Interactions in Maintaining SAGA Deubiquitinating Module Structure and ActivityLength of the active-site crossover loop defines the substrate specificity of ubiquitin C-terminal hydrolases for ubiquitin chainsStabilization of an Unusual Salt Bridge in Ubiquitin by the Extra C-Terminal Domain of the Proteasome-Associated Deubiquitinase UCH37 as a Mechanism of Its Exo SpecificityStructural basis for targeting the chromatin repressor Sfmbt to Polycomb response elementsPrognostic parameters in uveal melanoma and their association with BAP1 expression.Complementary genetic screens identify the E3 ubiquitin ligase CBLC, as a modifier of PARP inhibitor sensitivity.Loss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC inhibitors.Consensus report of the 2015 Weinman International Conference on MesotheliomaUncovering the role of Sgf73 in maintaining SAGA deubiquitinating module structure and activity.The roles of chromatin-remodelers and epigenetic modifiers in kidney cancerConnecting molecular pathways to hereditary cancer risk syndromesMithramycin Depletes Specificity Protein 1 and Activates p53 to Mediate Senescence and Apoptosis of Malignant Pleural Mesothelioma CellsMinimal asbestos exposure in germline BAP1 heterozygous mice is associated with deregulated inflammatory response and increased risk of mesotheliomaLatest developments in our understanding of the pathogenesis of mesothelioma and the design of targeted therapiesCombined Genetic and Genealogic Studies Uncover a Large BAP1 Cancer Syndrome Kindred Tracing Back Nine Generations to a Common Ancestor from the 1700sDrosophila melanogaster dHCF interacts with both PcG and TrxG epigenetic regulatorsMaintenance of adult cardiac function requires the chromatin factor Asxl2Additional sex combs-like family genes are required for normal cardiovascular developmentMyelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutations
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Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
@ast
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
@en
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
@en-gb
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
@nl
type
label
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
@ast
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
@en
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
@en-gb
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
@nl
prefLabel
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
@ast
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
@en
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
@en-gb
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
@nl
P2093
P2860
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P3181
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P1476
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
@en
P2093
Andrés Gaytán de Ayala Alonso
Johanna C Scheuermann
Jürg Müller
Nga Ly-Hartig
Robert K McGinty
Sven Fraterman
Tom W Muir
P2860
P2888
P3181
P356
10.1038/NATURE08966
P407
P577
2010-05-13T00:00:00Z
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P6179
1021168280