Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes
about
Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosisAnalysis of Rad3 and Chk1 protein kinases defines different checkpoint responses.ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sitesChk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damageSynaptonemal complex morphogenesis and sister-chromatid cohesion require Mek1-dependent phosphorylation of a meiotic chromosomal protein.Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway.Analysis of 11q21-24 loss of heterozygosity candidate target genes in breast cancer: indications of TSLC1 promoter hypermethylationRoles of Chk1 in cell biology and cancer therapyTopBP1 and ATR colocalization at meiotic chromosomes: role of TopBP1/Cut5 in the meiotic recombination checkpointCaspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene functionBasis for the checkpoint signal specificity that regulates Chk1 and Cds1 protein kinases.Cul4A is essential for spermatogenesis and male fertility.DNA damage: a sensible mediator of the differentiation decision in hematopoietic stem cells and in leukemia.Grp/DChk1 is required for G2-M checkpoint activation in Drosophila S2 cells, whereas Dmnk/DChk2 is dispensableKey mediators of somatic ATR signaling localize to unpaired chromosomes in spermatocytes.The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extractsThe role of NBS1 in the modulation of PIKK family proteins ATM and ATR in the cellular response to DNA damageThe cellular control of DNA double-strand breaks.Cdc25 inhibited in vivo and in vitro by checkpoint kinases Cds1 and Chk1Gene products of chromosome 11q and their association with CCND1 gene amplification and tamoxifen resistance in premenopausal breast cancer.Chromatin remodeling finds its place in the DNA double-strand break response.The DNA damage checkpoint protein RAD9A is essential for male meiosis in the mouse.DNA damage and replication checkpoints in fission yeast require nuclear exclusion of the Cdc25 phosphatase via 14-3-3 binding.Meiotic telomere distribution and Sertoli cell nuclear architecture are altered in Atm- and Atm-p53-deficient mice.p53 down-regulates CHK1 through p21 and the retinoblastoma proteinMutant alleles of Schizosaccharomyces pombe rad9(+) alter hydroxyurea resistance, radioresistance and checkpoint control.Meiotic DNA replication checkpoint control in fission yeast.Chk1 complements the G2/M checkpoint defect and radiosensitivity of ataxia-telangiectasia cells.Maintenance of imaginal disc plasticity and regenerative potential in Drosophila by p53.Checkpoint kinase 1 (CHK1) protein and mRNA expression is downregulated in aggressive variants of human lymphoid neoplasms.Detection of CHK1 and CCND1 gene copy number changes in breast cancer with dual-colour fluorescence in-situ hybridization.CHEK1 coordinates DNA damage signaling and meiotic progression in the male germline of mice.UCN-01 abrogates G2 arrest through a Cdc2-dependent pathway that is associated with inactivation of the Wee1Hu kinase and activation of the Cdc25C phosphatase.
P2860
Q24336800-21505BC2-4DB3-4EF2-BA53-8F39B26DE18AQ24533460-5D7D0295-A99C-4E0E-9A05-24A726D3E813Q24550952-D099F547-6BAB-4D1F-920E-9B77729C1213Q24610054-67632AEE-7D28-4447-A0A6-4321A3E42098Q24610106-D72B4D10-7230-4184-89B3-3CE17C8B78F3Q24651421-0873ED56-FF41-495B-B429-A3F894B7CD77Q27930215-9A69B6BF-8A63-4B6D-AD7C-B314FB33AABDQ27938580-75C13B3C-F4E0-4E30-88F6-0227AB77D564Q28214329-C41CF6A9-8F94-4B78-A9B4-2FACA0C84175Q28289548-4966ED69-E1CD-4D52-A4D4-2916D1F21AEEQ28508190-76EB85A8-6C96-40CD-8981-C0B65E7010FFQ28587062-11B9B671-28F9-41E5-B26F-DFBDFF90BFDDQ33652271-60FA9794-5AFA-43F8-8419-2DB6BB58BD6EQ34162380-C0912458-7857-4352-A7A5-5FAFE2E14E76Q35381608-5716DA78-40FE-4F32-ACA6-DE93EB0C2FC9Q35637855-569CA83C-DA81-4FC0-A29F-7A4D31B42E77Q35713281-EAF4A024-4564-4BEA-BB53-BF2888D19268Q36276718-589BE7A9-84FB-49CC-97C6-FCEE551A6FD2Q36418531-D48DC70D-8BED-44DD-97A8-2C931CEB9172Q36574666-9A3D877C-0306-4EBA-8F21-962CE8FE2C97Q36847253-9A469350-E395-466F-82CF-E10F45FDE38FQ37038663-784BAEC7-D23E-4EEA-AB4A-4D7C4CF8A8A3Q37128128-614DF960-C098-4DFE-B5CC-F060100C9CDCQ37132504-43F0E5B8-2A1B-4782-A74E-D7597C3FE961Q39448435-B74129C8-96F3-4CCE-A836-D1A3D5A7F5EDQ39456159-42A999C1-39A1-4248-B93A-6403857474F3Q39526736-A63953EA-D153-4D31-8C48-79C46D4352CDQ39597444-526D2832-4877-4D90-97C7-3D6C78B7FD73Q40445490-6E7BA247-EFD6-416C-B2E0-7C8A30408A66Q40976743-BA843C01-5F56-441C-A6AE-0116A4FCE51FQ42094854-88DD0535-14D4-4406-B486-995DD4CCAA79Q45138887-664508A4-DB98-427E-83F6-9FF0E0E843A7Q45797188-60C7422D-FD32-484B-BC5A-7066003626A6Q50423666-BF6E01E9-74B7-424E-97DF-B66D7E89CFEDQ54114456-5FF2907F-55F5-47D8-A3B6-83773F4EFE35
P2860
Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes
description
1997 nî lūn-bûn
@nan
1997 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes
@ast
Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes
@en
Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes
@en-gb
Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes
@nl
type
label
Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes
@ast
Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes
@en
Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes
@en-gb
Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes
@nl
prefLabel
Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes
@ast
Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes
@en
Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes
@en-gb
Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes
@nl
P2093
P1433
P1476
Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes
@en
P2093
C H Westphal
E M Taylor
M F Hoekstra
M R Quiggle
P304
P356
10.1016/S0960-9822(06)00417-9
P407
P577
1997-12-01T00:00:00Z