Loops govern SH2 domain specificity by controlling access to binding pockets
about
Specificity of linear motifs that bind to a common mitogen-activated protein kinase docking grooveEvolution of SH2 domains and phosphotyrosine signalling networksCrystal structure of human protein tyrosine phosphatase SHP-1 in the open conformationTwo Closely Spaced Tyrosines Regulate NFAT Signaling in B Cells via Syk Association with VavSimultaneous Binding of Two Peptidyl Ligands by a Src Homology 2 DomainDifferential recognition of syk-binding sites by each of the two phosphotyrosine-binding pockets of the Vav SH2 domainSuperbinder SH2 domains act as antagonists of cell signalingTwo Amino Acid Residues Confer Different Binding Affinities of Abelson Family Kinase Src Homology 2 Domains for Phosphorylated CortactinDynamically Coupled Residues within the SH2 Domain of FYN Are Key to Unlocking Its ActivityHigh-throughput analysis of peptide-binding modulesA lack of peptide binding and decreased thermostability suggests that the CASKIN2 scaffolding protein SH3 domain may be vestigial.Designing specific protein-protein interactions using computation, experimental library screening, or integrated methodsDomPep--a general method for predicting modular domain-mediated protein-protein interactionsMechanism of phosphorylation-induced activation of phospholipase C-gamma isozymes.A Proteome-wide Domain-centric Perspective on Protein Phosphorylation.Structural basis of recognition of interferon-α receptor by tyrosine kinase 2Towards mimicking short linear peptide motifs: identification of new mixed α,β-peptidomimetic ligands for SLAM-Associated Protein (SAP) by confocal on-bead screening.Achieving peptide binding specificity and promiscuity by loops: case of the forkhead-associated domain.Phosphotyrosine recognition domains: the typical, the atypical and the versatile.Tyrosine phosphorylation of the Lyn Src homology 2 (SH2) domain modulates its binding affinity and specificity.Structural insights into the intertwined dimer of fyn SH2Crucial roles of single residues in binding affinity, specificity, and promiscuity in the cellulosomal cohesin-dockerin interface¹H, ¹³C and ¹⁵N backbone and side-chain chemical shift assignments of the free and bound forms of the human PTPN11 second SH2 domain.Diversity in peptide recognition by the SH2 domain of SH2B1.Minimotif Miner 4: a million peptide minimotifs and counting.Creation of Phosphotyrosine Superbinders by Directed Evolution of an SH2 Domain.High STAP1 expression in DUX4-rearranged cases is not suitable as therapeutic target in pediatric B-cell precursor acute lymphoblastic leukemia.
P2860
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P2860
Loops govern SH2 domain specificity by controlling access to binding pockets
description
2010 nî lūn-bûn
@nan
2010 թուականին հրատարակուած գիտական յօդուած
@hyw
2010 թվականին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Loops govern SH2 domain specificity by controlling access to binding pockets
@ast
Loops govern SH2 domain specificity by controlling access to binding pockets
@en
Loops govern SH2 domain specificity by controlling access to binding pockets
@en-gb
Loops govern SH2 domain specificity by controlling access to binding pockets
@nl
type
label
Loops govern SH2 domain specificity by controlling access to binding pockets
@ast
Loops govern SH2 domain specificity by controlling access to binding pockets
@en
Loops govern SH2 domain specificity by controlling access to binding pockets
@en-gb
Loops govern SH2 domain specificity by controlling access to binding pockets
@nl
prefLabel
Loops govern SH2 domain specificity by controlling access to binding pockets
@ast
Loops govern SH2 domain specificity by controlling access to binding pockets
@en
Loops govern SH2 domain specificity by controlling access to binding pockets
@en-gb
Loops govern SH2 domain specificity by controlling access to binding pockets
@nl
P2093
P921
P3181
P1433
P1476
Loops govern SH2 domain specificity by controlling access to binding pockets
@en
P2093
Chenggang Wu
Courtney K Voss
Haiming Huang
Huadong Liu
Martin R Schiller
Shawn Shun-Cheng Li
P3181
P356
10.1126/SCISIGNAL.2000796
P407
P577
2010-01-01T00:00:00Z