The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing
about
Microinjection of specific anti-IMPDH2 antibodies induces disassembly of cytoplasmic rods/rings that are primarily stationary and stable structuresmiRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOTAgo2/miRISC-mediated inhibition of CBP80/20-dependent translation and thereby abrogation of nonsense-mediated mRNA decay require the cap-associating activity of Ago2Structural features of Argonaute-GW182 protein interactionsPost-transcriptional gene silencing, transcriptional gene silencing and human immunodeficiency virusThe Crystal Structure of Human Argonaute2Anti-PABPC1 co-immunoprecipitation for examining the miRNAs directly targeting the 3'-UTR of EED mRNAAn miRNA-mediated therapy for SCA6 blocks IRES-driven translation of the CACNA1A second cistronIntegrative data analysis indicates an intrinsic disordered domain character of Argonaute-binding motifs.The microRNA and messengerRNA profile of the RNA-induced silencing complex in human primary astrocyte and astrocytoma cellsRepression of GW/P body components and the RNAi microprocessor impacts primary ciliogenesis in human astrocytesAgo-TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps.The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC.Promoter RNA links transcriptional regulation of inflammatory pathway genes.The NS1 protein of influenza A virus interacts with cellular processing bodies and stress granules through RNA-associated protein 55 (RAP55) during virus infectionHepatitis B virus-specific miRNAs and Argonaute2 play a role in the viral life cycle.Why mouse oocytes and early embryos ignore miRNAs?Divergent GW182 functional domains in the regulation of translational silencing.MicroRNAs in rheumatoid arthritis.From guide to target: molecular insights into eukaryotic RNA-interference machinery.Biogenesis of mammalian microRNAs by a non-canonical processing pathwayThe Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes.P-bodies and stress granules: possible roles in the control of translation and mRNA degradation.Keratinization-associated miR-7 and miR-21 regulate tumor suppressor reversion-inducing cysteine-rich protein with kazal motifs (RECK) in oral cancer.A molecular link between miRISCs and deadenylases provides new insight into the mechanism of gene silencing by microRNAs.Mechanism of allele-selective inhibition of huntingtin expression by duplex RNAs that target CAG repeats: function through the RNAi pathwayEthanol facilitates hepatitis C virus replication via up-regulation of GW182 and heat shock protein 90 in human hepatoma cellsHypoxia-responsive miRNAs target argonaute 1 to promote angiogenesisMapping the human miRNA interactome by CLASH reveals frequent noncanonical bindingCirculating miRNAs: cell-cell communication function?The GW182 protein family in animal cells: new insights into domains required for miRNA-mediated gene silencing.MicroRNA-mediated posttranscriptional mechanisms of gene expression in proliferating and quiescent cancer cells.Argonaute and GW182 proteins: an effective alliance in gene silencing.Conservation of miRNA-mediated silencing mechanisms across 600 million years of animal evolution.Importin-β facilitates nuclear import of human GW proteins and balances cytoplasmic gene silencing protein levels.Control of the localization and function of a miRNA silencing component TNRC6A by Argonaute protein.PABP is not essential for microRNA-mediated translational repression and deadenylation in vitro.HSP90 protein stabilizes unloaded argonaute complexes and microscopic P-bodies in human cells.Trinucleotide repeat containing 6c (TNRC6c) is essential for microvascular maturation during distal airspace sacculation in the developing lung.Argonaute Utilization for miRNA Silencing Is Determined by Phosphorylation-Dependent Recruitment of LIM-Domain-Containing Proteins.
P2860
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P2860
The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing
description
2009 nî lūn-bûn
@nan
2009 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
The C-terminal half of human A ...... res GW182 to mediate silencing
@ast
The C-terminal half of human A ...... res GW182 to mediate silencing
@en
The C-terminal half of human A ...... res GW182 to mediate silencing
@en-gb
The C-terminal half of human A ...... res GW182 to mediate silencing
@nl
type
label
The C-terminal half of human A ...... res GW182 to mediate silencing
@ast
The C-terminal half of human A ...... res GW182 to mediate silencing
@en
The C-terminal half of human A ...... res GW182 to mediate silencing
@en-gb
The C-terminal half of human A ...... res GW182 to mediate silencing
@nl
prefLabel
The C-terminal half of human A ...... res GW182 to mediate silencing
@ast
The C-terminal half of human A ...... res GW182 to mediate silencing
@en
The C-terminal half of human A ...... res GW182 to mediate silencing
@en-gb
The C-terminal half of human A ...... res GW182 to mediate silencing
@nl
P2093
P2860
P356
P1433
P1476
The C-terminal half of human A ...... res GW182 to mediate silencing
@en
P2093
Brad A Pauley
Edward K L Chan
Grant X Abadal
Shang L Lian
Songqing Li
P2860
P304
P356
10.1261/RNA.1229409
P407
P577
2009-05-01T00:00:00Z