Histone recognition and large-scale structural analysis of the human bromodomain family
about
The bromodomain protein Brd4 insulates chromatin from DNA damage signallingStructural insights into recognition of acetylated histone ligands by the BRPF1 bromodomainPhospho switch triggers Brd4 chromatin binding and activator recruitment for gene-specific targetingDisrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancerGatekeepers of chromatin: Small metabolites elicit big changes in gene expressionEpimutational profile of hematologic malignancies as attractive target for new epigenetic therapiesThe multifaceted role of lysine acetylation in cancer: prognostic biomarker and therapeutic targetOpen access chemical probes for epigenetic targetsManipulation of the host protein acetylation network by human immunodeficiency virus type 1Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)Bromodomain proteins in HIV infectionEpigenetics: the fine-tuner in inflammatory bowel disease?KATs in cancer: functions and therapiesThe bromodomain: from epigenome reader to druggable targetSynthetic peptide arrays for investigating protein interaction domainsMechanisms of Histone Deacetylase Inhibitor-Regulated Gene Expression in Cancer CellsEncoding asymmetry of the N-glycosylation motif facilitates glycoprotein evolutionBromodomain Proteins Contribute to Maintenance of Bloodstream Form Stage Identity in the African TrypanosomeRegulatory T Cell Modulation by CBP/EP300 Bromodomain InhibitionIdentification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived HitOptimization of 3,5-Dimethylisoxazole Derivatives as Potent Bromodomain LigandsCyclin-Dependent Kinase Inhibitor Dinaciclib Interacts with the Acetyl-Lysine Recognition Site of BromodomainsDiscovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual ScreeningStructure-Guided Design of Potent Diazobenzene Inhibitors for the BET BromodomainsThe double PHD finger domain of MOZ/MYST3 induces -helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modificationRVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomainTargeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B BromodomainStructural Insights into Acetylated-Histone H4 Recognition by the Bromodomain-PHD Finger Module of Human Transcriptional Coactivator CBPAcetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase InhibitorsDual kinase-bromodomain inhibitors for rationally designed polypharmacologyBinding of the histone chaperone ASF1 to the CBP bromodomain promotes histone acetylationSelective Chemical Modulation of Gene Transcription Favors Oligodendrocyte Lineage ProgressionStructure of the p300 catalytic core and implications for chromatin targeting and HAT regulationDifferent orientations of low-molecular-weight fragments in the binding pocket of a BRD4 bromodomain4-Acyl pyrroles: mimicking acetylated lysines in histone code readingObserved bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2Structure-Based Design of γ-Carboline Analogues as Potent and Specific BET Bromodomain InhibitorsAtad2 is a generalist facilitator of chromatin dynamics in embryonic stem cellsNMR Fragment Screening Hit Induces Plasticity of BRD7/9 BromodomainsDiscovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis
P2860
Q24294320-B828BBB7-E765-4617-BEC2-0D56CBE07A3FQ24305108-D6787DB4-0249-4AB6-A6AF-60BF9305F285Q24308867-79CED0AC-4E9A-47EC-ABF2-05580046ABFFQ24337204-1A88AB16-7866-4B20-AB5B-D644C90D2D5CQ24622821-2B41BDE8-99ED-4768-B6FF-E4C161A984E0Q26744080-D56008FE-0154-4F48-A48C-2844757CEB37Q26744292-1734119C-091A-4390-A174-83ECB87E4D11Q26781872-9A4505A6-F881-4122-93A9-74A95DDAA99FQ26795463-23C0DCC1-CEFC-45FD-B6AB-672B5A93ABFAQ26823798-0EA0FA0A-6A0B-40BD-A213-6986D993FE15Q26829860-588E2171-8886-4A61-B695-D6EE520A3C40Q26853555-F1D05B46-40E6-4469-B09D-4ED6BB162550Q26859355-414001E0-B59D-49C8-A37D-DF755A34045FQ26999935-F55CAC99-BA18-44C8-9322-CCE8EC2AB6C4Q27002520-A91627EF-C25D-4428-B360-96BB3047DFFBQ27015931-5872B813-E107-42A5-9FBB-460EE3F968D3Q27332084-9F15928D-8E90-446B-ACA7-266762765E43Q27345564-1E2098AB-42E4-455F-8975-4D0635517246Q27644651-C5B4B439-5F5E-4038-B61C-0F88715DF33BQ27674710-D3B0D4E8-3B8C-4996-9B64-B5E3C94F6608Q27676915-57654F81-291A-4E45-8C50-AFAEBC369A52Q27679876-3155C3E1-3F46-4ADA-81A4-80003F1986C5Q27680134-4BD7160C-4765-4051-9B36-416F0454389FQ27680405-F057F18C-7379-4C05-BABA-7F162DCC91BBQ27680427-EB75EAC6-9F56-4200-BC0D-E34B3A71B54BQ27680635-70478DAB-99FE-4AE8-8D2C-4676628632C3Q27680754-94D55888-D9D6-4D2B-B174-263260227AFEQ27681018-0185D948-7049-4E17-A2C5-802256EB46BAQ27681896-C8BDC454-38CD-49D3-AEFF-CC2DFF05C6B7Q27681935-E39657AB-49D6-4303-A7F6-110039C2DF05Q27682105-B5073772-7282-4514-BA6A-05EA8C7E1B71Q27684429-2FBA0993-53AE-49C5-9C45-4AFBA9C167CDQ27685367-2E45B7F5-F03F-4C3E-9B79-5E7B8FCEF73CQ27687015-FB3BBBDF-23DA-4907-B815-B51C2C66AFC7Q27687671-3D6E4114-F29F-4219-8D21-949662C797F6Q27696569-0FF870F8-5A3C-4A9C-9071-725536CAF7A6Q27701027-78162D7B-70A1-4BBE-AE2B-D0A9CEF91906Q27702290-B24DA7E2-1508-44AE-9948-43EFA5A1CFBCQ27704896-EC11E892-D892-42FE-950B-5F1721FF02F5Q27728041-269C9182-6698-47F7-84B8-249B920BEAE4
P2860
Histone recognition and large-scale structural analysis of the human bromodomain family
description
2012 nî lūn-bûn
@nan
2012 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մարտին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Histone recognition and large-scale structural analysis of the human bromodomain family
@ast
Histone recognition and large-scale structural analysis of the human bromodomain family
@en
Histone recognition and large-scale structural analysis of the human bromodomain family
@en-gb
Histone recognition and large-scale structural analysis of the human bromodomain family
@nl
type
label
Histone recognition and large-scale structural analysis of the human bromodomain family
@ast
Histone recognition and large-scale structural analysis of the human bromodomain family
@en
Histone recognition and large-scale structural analysis of the human bromodomain family
@en-gb
Histone recognition and large-scale structural analysis of the human bromodomain family
@nl
altLabel
Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family
@en
prefLabel
Histone recognition and large-scale structural analysis of the human bromodomain family
@ast
Histone recognition and large-scale structural analysis of the human bromodomain family
@en
Histone recognition and large-scale structural analysis of the human bromodomain family
@en-gb
Histone recognition and large-scale structural analysis of the human bromodomain family
@nl
P2093
P2860
P50
P921
P3181
P1433
P1476
Histone recognition and large-scale structural analysis of the human bromodomain family
@en
P2093
Ildiko Felletar
Jean-Philippe Lambert
Maria Mangos
Tracy Keates
P2860
P304
P3181
P356
10.1016/J.CELL.2012.02.013
P407
P50
P577
2012-03-30T00:00:00Z