C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2
about
Centrosome dysfunction contributes to chromosome instability, chromoanagenesis, and genome reprograming in cancerCentrosome-associated regulators of the G(2)/M checkpoint as targets for cancer therapyBasal body stability and ciliogenesis requires the conserved component Poc1NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesionA novel ninein-interaction protein, CGI-99, blocks ninein phosphorylation by GSK3beta and is highly expressed in brain tumorsSIK2 is a centrosome kinase required for bipolar mitotic spindle formation that provides a potential target for therapy in ovarian cancerPrimary ciliogenesis requires the distal appendage component Cep123.Cep164, a novel centriole appendage protein required for primary cilium formationPoc1A and Poc1B act together in human cells to ensure centriole integrityCentriolar association of ALMS1 and likely centrosomal functions of the ALMS motif-containing proteins C10orf90 and KIAA1731Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinaseCentrobin-tubulin interaction is required for centriole elongation and stabilityNek11, a new member of the NIMA family of kinases, involved in DNA replication and genotoxic stress responsesbeta-Catenin is a Nek2 substrate involved in centrosome separation.Conductin/axin2 and Wnt signalling regulates centrosome cohesion.RBM14 prevents assembly of centriolar protein complexes and maintains mitotic spindle integrityComponents of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunctionTSKS concentrates in spermatid centrioles during flagellogenesisThe FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis.Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/CRootletin forms centriole-associated filaments and functions in centrosome cohesionMitotic regulation by NIMA-related kinasesSAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cellsCEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia baseDynamic recruitment of Nek2 kinase to the centrosome involves microtubules, PCM-1, and localized proteasomal degradation.Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase.Alternative splice variants of the human centrosome kinase Nek2 exhibit distinct patterns of expression in mitosisCloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cellsA complex of two centrosomal proteins, CAP350 and FOP, cooperates with EB1 in microtubule anchoring.The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centriolesRegulated HsSAS-6 levels ensure formation of a single procentriole per centriole during the centrosome duplication cycleCharacterization of Cep135, a novel coiled-coil centrosomal protein involved in microtubule organization in mammalian cellsCyclin-dependent kinase control of centrosome duplicationRootletin, a novel coiled-coil protein, is a structural component of the ciliary rootletDistinct cell cycle-dependent roles for dynactin and dynein at centrosomesA novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phaseNek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindlesIrod/Ian5: an inhibitor of gamma-radiation- and okadaic acid-induced apoptosis
P2860
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P2860
C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2
description
1998 nî lūn-bûn
@nan
1998 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
C-Nap1, a novel centrosomal co ...... -regulated protein kinase Nek2
@ast
C-Nap1, a novel centrosomal co ...... -regulated protein kinase Nek2
@en
C-Nap1, a novel centrosomal co ...... -regulated protein kinase Nek2
@en-gb
C-Nap1, a novel centrosomal co ...... -regulated protein kinase Nek2
@nl
type
label
C-Nap1, a novel centrosomal co ...... -regulated protein kinase Nek2
@ast
C-Nap1, a novel centrosomal co ...... -regulated protein kinase Nek2
@en
C-Nap1, a novel centrosomal co ...... -regulated protein kinase Nek2
@en-gb
C-Nap1, a novel centrosomal co ...... -regulated protein kinase Nek2
@nl
prefLabel
C-Nap1, a novel centrosomal co ...... -regulated protein kinase Nek2
@ast
C-Nap1, a novel centrosomal co ...... -regulated protein kinase Nek2
@en
C-Nap1, a novel centrosomal co ...... -regulated protein kinase Nek2
@en-gb
C-Nap1, a novel centrosomal co ...... -regulated protein kinase Nek2
@nl
P2093
P2860
P921
P3181
P356
P1476
C-Nap1, a novel centrosomal co ...... -regulated protein kinase Nek2
@en
P2093
P2860
P304
P3181
P356
10.1083/JCB.141.7.1563
P407
P577
1998-06-29T00:00:00Z