Three-dimensional structure of I(to); Kv4.2-KChIP2 ion channels by electron microscopy at 21 Angstrom resolution
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The stoichiometry and biophysical properties of the Kv4 potassium channel complex with K+ channel-interacting protein (KChIP) subunits are variable, depending on the relative expression levelI SA channel complexes include four subunits each of DPP6 and Kv4.2Structural basis for modulation of Kv4 K+ channels by auxiliary KChIP subunitsThree-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamerNeuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signallingPentameric Assembly of Potassium Channel Tetramerization Domain-Containing Protein 5C-terminal domain of Kv4.2 and associated KChIP2 interactions regulate functional expression and gating of Kv4.2Single particle image reconstruction of the human recombinant Kv2.1 channel.Localization and targeting of voltage-dependent ion channels in mammalian central neurons.FitEM2EM--tools for low resolution study of macromolecular assembly and dynamicsActin filament labels for localizing protein components in large complexes viewed by electron microscopy.A 3.5-nm structure of rat TRPV4 cation channel revealed by Zernike phase-contrast cryoelectron microscopyThe carboxyl-terminal region of cyclic nucleotide-modulated channels is a gating ring, not a permeation path.Functional rescue of Kv4.3 channel tetramerization mutants by KChIP4a.The membrane protein MiRP3 regulates Kv4.2 channels in a KChIP-dependent manner.The tetramerization domain potentiates Kv4 channel function by suppressing closed-state inactivation.K(V)4.3 N-terminal deletion mutant Δ2-39: effects on inactivation and recovery characteristics in both the absence and presence of KChIP2b.The "structurally minimal" isoform KChIP2d modulates recovery of K(v)4.3 N-terminal deletion mutant Δ2-39Serial perturbation of MinK in IKs implies an alpha-helical transmembrane span traversing the channel corpus.Transient outward potassium current, 'Ito', phenotypes in the mammalian left ventricle: underlying molecular, cellular and biophysical mechanisms.Impact of ancillary subunits on ventricular repolarization.KChIP2 genotype dependence of transient outward current (Ito) properties in cardiomyocytes isolated from male and female mice.Cryo-EM and single particles.Total chemical synthesis and biophysical characterization of the minimal isoform of the KChIP2 potassium channel regulatory subunitFunctionally active t1-t1 interfaces revealed by the accessibility of intracellular thiolate groups in kv4 channelsFunctional stoichiometry underlying KChIP regulation of Kv4.2 functional expressionTRP channels entering the structural era.Closed-state inactivation in Kv4.3 isoforms is differentially modulated by protein kinase C.Mechanisms of closed-state inactivation in voltage-gated ion channels.Cytoplasmic domains and voltage-dependent potassium channel gating.Modulation of human Kv4.3/KChIP2 channel inactivation kinetics by cytoplasmic Ca²⁺.Voltage-dependent gating rearrangements in the intracellular T1-T1 interface of a K+ channel.Molecular assembly and dynamics of fluorescent protein-tagged single KCa1.1 channel in expression system and vascular smooth muscle cells.DPP10 is an inactivation modulatory protein of Kv4.3 and Kv1.4.KChIP3 rescues the functional expression of Shal channel tetramerization mutants.Contribution of N- and C-terminal Kv4.2 channel domains to KChIP interaction [corrected].
P2860
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P2860
Three-dimensional structure of I(to); Kv4.2-KChIP2 ion channels by electron microscopy at 21 Angstrom resolution
description
2004 nî lūn-bûn
@nan
2004 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Three-dimensional structure of ...... copy at 21 Angstrom resolution
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Three-dimensional structure of ...... copy at 21 Angstrom resolution
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Three-dimensional structure of ...... copy at 21 Angstrom resolution
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Three-dimensional structure of ...... copy at 21 Angstrom resolution
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type
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Three-dimensional structure of ...... copy at 21 Angstrom resolution
@ast
Three-dimensional structure of ...... copy at 21 Angstrom resolution
@en
Three-dimensional structure of ...... copy at 21 Angstrom resolution
@en-gb
Three-dimensional structure of ...... copy at 21 Angstrom resolution
@nl
prefLabel
Three-dimensional structure of ...... copy at 21 Angstrom resolution
@ast
Three-dimensional structure of ...... copy at 21 Angstrom resolution
@en
Three-dimensional structure of ...... copy at 21 Angstrom resolution
@en-gb
Three-dimensional structure of ...... copy at 21 Angstrom resolution
@nl
P2093
P1433
P1476
Three-dimensional structure of ...... copy at 21 Angstrom resolution
@en
P2093
David Gutierrez
Johannes Furst
Margaret H Butler
Nikolaus Grigorieff
P304
P356
10.1016/S0896-6273(04)00050-9
P407
P577
2004-02-01T00:00:00Z