The phosphorylated 1169-tyrosine containing region of flt-1 kinase (VEGFR-1) is a major binding site for PLCgamma
about
Homeostatic modulation of cell surface KDR and Flt1 expression and expression of the vascular endothelial cell growth factor (VEGF) receptor mRNAs by VEGFA single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cellsDirect identification of a major autophosphorylation site on vascular endothelial growth factor receptor Flt-1 that mediates phosphatidylinositol 3'-kinase bindingIn vivo mechanisms of vascular endothelial growth factor-mediated increased hydraulic conductivity of Rana capillariesQuercetin-4'-O-β-D-glucopyranoside (QODG) inhibits angiogenesis by suppressing VEGFR2-mediated signaling in zebrafish and endothelial cellsFlt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in miceVascular endothelial growth factor A (VEGF-A) is involved in guidance of VEGF receptor-positive cells to the anterior portion of early embryosAbsence of erythrogenesis and vasculogenesis in Plcg1-deficient miceVascular endothelial growth factor (VEGF)-driven actin-based motility is mediated by VEGFR2 and requires concerted activation of stress-activated protein kinase 2 (SAPK2/p38) and geldanamycin-sensitive phosphorylation of focal adhesion kinaseIdentification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing moleculesThe role of individual SH2 domains in mediating association of phospholipase C-gamma1 with the activated EGF receptorVascular endothelial growth factor signaling in hypoxia and inflammation.Growth factor signaling pathways in vascular development.A Phase II trial of tandutinib (MLN 518) in combination with bevacizumab for patients with recurrent glioblastoma.Molecular diversity of VEGF-A as a regulator of its biological activity.Placental growth factor induces FosB and c-Fos gene expression via Flt-1 receptors.Antiangiogenic agents targeting vascular endothelial growth factor and its receptors in clinical development.N-terminal cleavage and release of the ectodomain of Flt1 is mediated via ADAM10 and ADAM 17 and regulated by VEGFR2 and the Flt1 intracellular domainRetrospective analysis of protein kinase C-beta (PKC-beta) expression in lymphoid malignancies and its association with survival in diffuse large B-cell lymphomas.Vascular Endothelial Growth Factor (VEGF) and Its Receptor (VEGFR) Signaling in Angiogenesis: A Crucial Target for Anti- and Pro-Angiogenic TherapiesThe role of VEGF receptors in angiogenesis; complex partnershipsChimeric VEGFRs are activated by a small-molecule dimerizer and mediate downstream signalling cascades in endothelial cells.Activation of receptor-mediated angiogenesis and signaling pathways after VEGF administration in fetal rat CNS explants.Unlocking Doors without Keys: Activation of Src by Truncated C-terminal Intracellular Receptor Tyrosine Kinases Lacking Tyrosine Kinase Activity.RACK1 regulates VEGF/Flt1-mediated cell migration via activation of a PI3K/Akt pathway.A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3'-kinase activation and endothelial cell migrationA novel kinase mutation in VEGFR-1 predisposes its αC-helix/activation loop towards allosteric activation: Atomic insights from protein simulation.Vascular endothelial growth factor effect on endothelial cell proliferation, migration, and platelet-activating factor synthesis is Flk-1-dependent.A novel snake venom vascular endothelial growth factor (VEGF) predominantly induces vascular permeability through preferential signaling via VEGF receptor-1.Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific vascular endothelial growth factor mutants.Identification of functional VEGF receptors on human platelets.A phase II trial of enzastaurin (LY317615) in combination with bevacizumab in adults with recurrent malignant gliomas.Structure and function of vascular endothelial growth factor and its receptor system.Identification of key gene networks associated with fracture healing using αSMA‑labeled progenitor cells.Long non-coding RNA UBE2CP3 enhances HCC cell secretion of VEGFA and promotes angiogenesis by activating ERK1/2/HIF-1α/VEGFA signalling in hepatocellular carcinoma.Signal transduction induced in endothelial cells by growth factor receptors involved in angiogenesis.
P2860
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P2860
The phosphorylated 1169-tyrosine containing region of flt-1 kinase (VEGFR-1) is a major binding site for PLCgamma
description
1997 nî lūn-bûn
@nan
1997 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
The phosphorylated 1169-tyrosi ...... ajor binding site for PLCgamma
@ast
The phosphorylated 1169-tyrosi ...... ajor binding site for PLCgamma
@en
The phosphorylated 1169-tyrosi ...... ajor binding site for PLCgamma
@en-gb
The phosphorylated 1169-tyrosi ...... ajor binding site for PLCgamma
@nl
type
label
The phosphorylated 1169-tyrosi ...... ajor binding site for PLCgamma
@ast
The phosphorylated 1169-tyrosi ...... ajor binding site for PLCgamma
@en
The phosphorylated 1169-tyrosi ...... ajor binding site for PLCgamma
@en-gb
The phosphorylated 1169-tyrosi ...... ajor binding site for PLCgamma
@nl
prefLabel
The phosphorylated 1169-tyrosi ...... ajor binding site for PLCgamma
@ast
The phosphorylated 1169-tyrosi ...... ajor binding site for PLCgamma
@en
The phosphorylated 1169-tyrosi ...... ajor binding site for PLCgamma
@en-gb
The phosphorylated 1169-tyrosi ...... ajor binding site for PLCgamma
@nl
P2093
P921
P356
P1476
The phosphorylated 1169-tyrosi ...... ajor binding site for PLCgamma
@en
P2093
S Yamaguchi
T Takahashi
P304
P356
10.1006/BBRC.1997.7327
P407
P577
1997-09-18T00:00:00Z