Differential subcellular localizations of two human Sgo1 isoforms: implications in regulation of sister chromatid cohesion and microtubule dynamics
about
sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1Identification of the nuclear localization signal of SALL4B, a stem cell transcription factorSumoylated BubR1 plays an important role in chromosome segregation and mitotic timing.Sgo1 is a potential therapeutic target for hepatocellular carcinoma.Pharicin A, a novel natural ent-kaurene diterpenoid, induces mitotic arrest and mitotic catastrophe of cancer cells by interfering with BubR1 functionHaploinsufficiency of SGO1 results in deregulated centrosome dynamics, enhanced chromosomal instability and colon tumorigenesis.Suppression of genomic instabilities caused by chromosome mis-segregation: a perspective from studying BubR1 and Sgo1.Shugoshins function as a guardian for chromosomal stability in nuclear division.Mitotic checkpoint control and chromatin remodeling.Haplo-insufficiency of both BubR1 and SGO1 accelerates cellular senescence.Lentivirus-mediated siRNA interference targeting SGO-1 inhibits human NSCLC cell growth.Chromium induces chromosomal instability, which is partly due to deregulation of BubR1 and Emi1, two APC/C inhibitors.SGO1C is a non-functional isoform of Shugoshin and can disrupt sister chromatid cohesion by interacting with PP2A-B56Chromatin PTEN is involved in DNA damage response partly through regulating Rad52 sumoylation.Multiple anaphase-promoting complex/cyclosome degrons mediate the degradation of human Sgo1.
P2860
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P2860
Differential subcellular localizations of two human Sgo1 isoforms: implications in regulation of sister chromatid cohesion and microtubule dynamics
description
2006 nî lūn-bûn
@nan
2006 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մարտին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Differential subcellular local ...... esion and microtubule dynamics
@ast
Differential subcellular local ...... esion and microtubule dynamics
@en
Differential subcellular local ...... esion and microtubule dynamics
@en-gb
Differential subcellular local ...... esion and microtubule dynamics
@nl
type
label
Differential subcellular local ...... esion and microtubule dynamics
@ast
Differential subcellular local ...... esion and microtubule dynamics
@en
Differential subcellular local ...... esion and microtubule dynamics
@en-gb
Differential subcellular local ...... esion and microtubule dynamics
@nl
prefLabel
Differential subcellular local ...... esion and microtubule dynamics
@ast
Differential subcellular local ...... esion and microtubule dynamics
@en
Differential subcellular local ...... esion and microtubule dynamics
@en-gb
Differential subcellular local ...... esion and microtubule dynamics
@nl
P2093
P356
P1433
P1476
Differential subcellular local ...... esion and microtubule dynamics
@en
P2093
P304
P356
10.4161/CC.5.6.2547
P407
P577
2006-03-01T00:00:00Z