Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab
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Dual roles of the transcription factor grainyhead-like 2 (GRHL2) in breast cancerShould individual PI3 kinase isoforms be targeted in cancer?Human epidermal growth factor receptor signaling in acute lung injuryA Disintegrin and Metalloprotease 17 in the Cardiovascular and Central Nervous SystemsEMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancerA complex containing LPP and α-actinin mediates TGFβ-induced migration and invasion of ErbB2-expressing breast cancer cells.Identification of markers of taxane sensitivity using proteomic and genomic analyses of breast tumors from patients receiving neoadjuvant paclitaxel and radiation.ERBB receptors: from oncogene discovery to basic science to mechanism-based cancer therapeutics.The roles of TGFβ in the tumour microenvironment.Inhibition of Integrin-HER2 signaling by Cucurbitacin B leads to in vitro and in vivo breast tumor growth suppressionAn ErbB3 antibody, MM-121, is active in cancers with ligand-dependent activationDiscovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway.An integrated genomic approach identifies persistent tumor suppressive effects of transforming growth factor-β in human breast cancerCaveolin-1 is required for TGF-β-induced transactivation of the EGF receptor pathway in hepatocytes through the activation of the metalloprotease TACE/ADAM17.Most random gene expression signatures are significantly associated with breast cancer outcome.ALCAM/CD166 is a TGF-β-responsive marker and functional regulator of prostate cancer metastasis to boneInterleukin-1 stimulates ADAM17 through a mechanism independent of its cytoplasmic domain or phosphorylation at threonine 735TGFβ induces "BRCAness" and sensitivity to PARP inhibition in breast cancer by regulating DNA-repair genesAnticancer activity of Celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers.ZNF217, a candidate breast cancer oncogene amplified at 20q13, regulates expression of the ErbB3 receptor tyrosine kinase in breast cancer cellsContext-dependent bidirectional regulation of the MutS homolog 2 by transforming growth factor β contributes to chemoresistance in breast cancer cells.Transforming growth factor-β-induced epithelial-mesenchymal transition facilitates epidermal growth factor-dependent breast cancer progressionERBB receptor activation is required for profibrotic responses to transforming growth factor beta.The Functional Crosstalk between HER2 Tyrosine Kinase and TGF-β Signaling in Breast Cancer Malignancy.c-Jun N-terminal Kinase 2 Regulates Multiple Receptor Tyrosine Kinase Pathways in Mouse Mammary Tumor Growth and Metastasis.Pathway profiling and rational trial design for studies in advanced stage cervical carcinoma: a review and a perspective.Resistance to HER2-directed antibodies and tyrosine kinase inhibitors: mechanisms and clinical implications.Integrating molecular mechanisms and clinical evidence in the management of trastuzumab resistant or refractory HER-2⁺ metastatic breast cancer.Mechanisms of Trastuzumab resistance in ErbB2-driven breast cancer and newer opportunities to overcome therapy resistance.Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitors.Pharmacological strategies to overcome HER2 cross-talk and Trastuzumab resistance.All-trans-retinoic Acid Modulates the Plasticity and Inhibits the Motility of Breast Cancer Cells: ROLE OF NOTCH1 AND TRANSFORMING GROWTH FACTOR (TGFβ).Two dimensions in targeting HER2.Nuclear translocation of type I transforming growth factor β receptor confers a novel function in RNA processingIntrinsic and acquired resistance to HER2-targeted therapies in HER2 gene-amplified breast cancer: mechanisms and clinical implicationsWhen tumor suppressor TGFβ meets the HER2 (ERBB2) oncogene.Activating PIK3CA Mutations Induce an Epidermal Growth Factor Receptor (EGFR)/Extracellular Signal-regulated Kinase (ERK) Paracrine Signaling Axis in Basal-like Breast Cancer.Novel HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cellsCyclooxygenase-2 in tumor-associated macrophages promotes breast cancer cell survival by triggering a positive-feedback loop between macrophages and cancer cells.Distinct phosphotyrosine-dependent functions of the ShcA adaptor protein are required for transforming growth factor β (TGFβ)-induced breast cancer cell migration, invasion, and metastasis
P2860
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P248
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P2860
Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab
description
2008 nî lūn-bûn
@nan
2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Transforming growth factor bet ...... ensitizes cells to trastuzumab
@ast
Transforming growth factor bet ...... ensitizes cells to trastuzumab
@en
Transforming growth factor bet ...... ensitizes cells to trastuzumab
@en-gb
Transforming growth factor bet ...... ensitizes cells to trastuzumab
@nl
type
label
Transforming growth factor bet ...... ensitizes cells to trastuzumab
@ast
Transforming growth factor bet ...... ensitizes cells to trastuzumab
@en
Transforming growth factor bet ...... ensitizes cells to trastuzumab
@en-gb
Transforming growth factor bet ...... ensitizes cells to trastuzumab
@nl
prefLabel
Transforming growth factor bet ...... ensitizes cells to trastuzumab
@ast
Transforming growth factor bet ...... ensitizes cells to trastuzumab
@en
Transforming growth factor bet ...... ensitizes cells to trastuzumab
@en-gb
Transforming growth factor bet ...... ensitizes cells to trastuzumab
@nl
P2093
P2860
P921
P3181
P356
P1476
Transforming growth factor bet ...... ensitizes cells to trastuzumab
@en
P2093
Atanasio Pandiella
Carlos L Arteaga
Christine H Chung
Joel Parker
Maria Graciela Olivares
Marta Guix
Shizhen Emily Wang
P2860
P304
P3181
P356
10.1128/MCB.00787-08
P407
P577
2008-09-01T00:00:00Z