Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain
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Prediction of protein binding regions in disordered proteinsExpression of full-length p53 and its isoform Deltap53 in breast carcinomas in relation to mutation status and clinical parametersAnticancer peptide PNC-27 adopts an HDM-2-binding conformation and kills cancer cells by binding to HDM-2 in their membranesPeptides from the amino terminal mdm-2-binding domain of p53, designed from conformational analysis, are selectively cytotoxic to transformed cellsThe corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradationSmall-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblastsTRIAD1 inhibits MDM2-mediated p53 ubiquitination and degradationPhosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligaseIdentification of a second Nutlin-3 responsive interaction site in the N-terminal domain of MDM2 using hydrogen/deuterium exchange mass spectrometryTwo distinct domains in Staf to selectively activate small nuclear RNA-type and mRNA promotersStructural insight into the TFIIE-TFIIH interaction: TFIIE and p53 share the binding region on TFIIHp53 Stabilization and accumulation induced by human vaccinia-related kinase 1MDM4 binds ligands via a mechanism in which disordered regions become structuredThe DEAD box protein Ddx42p modulates the function of ASPP2, a stimulator of apoptosisRibosomal protein S27-like and S27 interplay with p53-MDM2 axis as a target, a substrate and a regulatorA C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism.VRK1 interacts with p53 forming a basal complex that is activated by UV-induced DNA damageHuman vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNKThe Mdm2 oncoprotein interacts with the cell fate regulator NumbAdenovirus E1B 55K represses p53 activation in vitro.Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.p53 downregulates its activating vaccinia-related kinase 1, forming a new autoregulatory loopElectrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifsDual roles of RNA helicase A in CREB-dependent transcriptionStructural basis of ligand interactions of the large extracellular domain of tetraspanin CD81Structural and functional characterization of an atypical activation domain in erythroid Kruppel-like factor (EKLF)DNA damage in oocytes induces a switch of the quality control factor TAp63α from dimer to tetramerChk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53Structural conservation of druggable hot spots in protein-protein interfacesTrp-26 imparts functional versatility to human alpha-defensin HNP1Effects of MDM2 promoter polymorphisms and p53 codon 72 polymorphism on risk and age at onset of squamous cell carcinoma of the head and neckSystematic analysis of helical protein interfaces reveals targets for synthetic inhibitorsDruggability Assessment of Allosteric Proteins by Dynamics Simulations in the Presence of Probe Moleculesp53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent mannerMapping the interactions of the p53 transactivation domain with the KIX domain of CBPSmall-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapyStructural basis for p300 Taz2-p53 TAD1 binding and modulation by phosphorylationCooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2The alpha-helical FXXPhiPhi motif in p53: TAF interaction and discrimination by MDM2NMR structure of a complex containing the TFIIF subunit RAP74 and the RNA polymerase II carboxyl-terminal domain phosphatase FCP1
P2860
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P2860
Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain
description
1996 nî lūn-bûn
@nan
1996 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Structure of the MDM2 oncoprot ...... pressor transactivation domain
@ast
Structure of the MDM2 oncoprot ...... pressor transactivation domain
@en
Structure of the MDM2 oncoprot ...... pressor transactivation domain
@en-gb
Structure of the MDM2 oncoprot ...... pressor transactivation domain
@nl
type
label
Structure of the MDM2 oncoprot ...... pressor transactivation domain
@ast
Structure of the MDM2 oncoprot ...... pressor transactivation domain
@en
Structure of the MDM2 oncoprot ...... pressor transactivation domain
@en-gb
Structure of the MDM2 oncoprot ...... pressor transactivation domain
@nl
prefLabel
Structure of the MDM2 oncoprot ...... pressor transactivation domain
@ast
Structure of the MDM2 oncoprot ...... pressor transactivation domain
@en
Structure of the MDM2 oncoprot ...... pressor transactivation domain
@en-gb
Structure of the MDM2 oncoprot ...... pressor transactivation domain
@nl
P2093
P3181
P1433
P1476
Structure of the MDM2 oncoprot ...... pressor transactivation domain
@en
P2093
A J Levine
B Elenbaas
N P Pavletich
P H Kussie
V Marechal
P304
P3181
P356
10.1126/SCIENCE.274.5289.948
P407
P577
1996-11-08T00:00:00Z