Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence
about
VHZ is a novel centrosomal phosphatase associated with cell growth and human primary cancersCervix carcinoma is associated with an up-regulation and nuclear localization of the dual-specificity protein phosphatase VHRVRK2 anchors KSR1-MEK1 to endoplasmic reticulum forming a macromolecular complex that compartmentalizes MAPK signalingProtein tyrosine phosphatases--from housekeeping enzymes to master regulators of signal transductionpCAP-based peptide substrates: the new tool in the box of tyrosine phosphatase assaysSmall molecule tools for functional interrogation of protein tyrosine phosphatasesMultidentate Small-Molecule Inhibitors of Vaccinia H1-Related (VHR) Phosphatase Decrease Proliferation of Cervix Cancer CellsNew Aspects of the Phosphatase VHZ Revealed by a High-Resolution Structure with Vanadate and Substrate ScreeningA Drosophila-centric view of protein tyrosine phosphatasesJNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stressA weak Lck tail bite is necessary for Lck function in T cell antigen receptor signaling.DUSP3/VHR is a pro-angiogenic atypical dual-specificity phosphatase.Multi-level reproducibility of signature hubs in human interactome for breast cancer metastasis.Potential tumor suppressor NESG1 as an unfavorable prognosis factor in nasopharyngeal carcinoma.Dual-Specificity Phosphatase CDC25A/B Inhibitor Identified from a Focused Library with Nonelectrophilic Core StructureSpecificity profiling of dual specificity phosphatase vaccinia VH1-related (VHR) reveals two distinct substrate binding modesWithaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity.Vaccinia H1-related phosphatase is a phosphatase of ErbB receptors and is down-regulated in non-small cell lung cancerA kinase shRNA screen links LATS2 and the pRB tumor suppressorIntercellular redistribution of cAMP underlies selective suppression of cancer cell growth by connexin26.Dual-specificity phosphatase 3 deficiency or inhibition limits platelet activation and arterial thrombosis.Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin.Enteric commensal bacteria induce extracellular signal-regulated kinase pathway signaling via formyl peptide receptor-dependent redox modulation of dual specific phosphatase 3.DUSP3 Genetic Deletion Confers M2-like Macrophage-Dependent Tolerance to Septic ShockPerspective: Tyrosine phosphatases as novel targets for antiplatelet therapy.Aberrant early-phase ERK inactivation impedes neuronal function in fragile X syndrome.Regulation of MAPKs by growth factors and receptor tyrosine kinasesThe monocytic population in chronic lymphocytic leukemia shows altered composition and deregulation of genes involved in phagocytosis and inflammation.KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling.Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity.The regulatory roles of phosphatases in cancer.VHR/DUSP3 phosphatase: structure, function and regulation.Deficiency in VHR/DUSP3, a suppressor of focal adhesion kinase, reveals its role in regulating cell adhesion and migration.DUSP13B/TMDP inhibits stress-activated MAPKs and suppresses AP-1-dependent gene expression.High intracellular Zn2+ ions modulate the VHR, ZAP-70 and ERK activities of LNCaP prostate cancer cells.Dual-Specificity Phosphatase 3 Deletion Protects Female, but Not Male, Mice from Endotoxemia-Induced and Polymicrobial-Induced Septic Shock.Inhibitory role of RhoA on senescence-like growth arrest by a mechanism involving modulation of phosphatase activity.Spatiotemporal regulation of ERK2 by dual specificity phosphatases.Dusp3 deletion in mice promotes experimental lung tumour metastasis in a macrophage dependent manner.Development of a Vaccinia H1-related (VHR) phosphatase inhibitor with a nonacidic phosphate-mimicking core structure.
P2860
Q21093278-36EEC1A0-FF8B-405C-9962-DA84C72355EEQ24316477-62B18655-4F7F-4C1F-B75F-1E72EC97C7B2Q24339458-59E38F70-CEDA-4EFD-9540-17717AA89493Q24622527-AD0A7725-9001-49B2-9C71-A6DD9F90FC74Q26830090-F57FE56B-5CC1-43E8-B615-DE9C65E1D5E0Q26852276-19B9E344-7A67-4C9A-9E0C-92991CE46580Q27658054-0558D6A9-7B46-4C02-A1EB-D20F9832CA49Q27675097-6CB7078D-8F61-41B3-8AF2-7D11820B8949Q28082271-0256EC5D-1A54-47C6-8841-66DD8227579EQ28910415-FEE524F3-3F33-48E9-B602-14876F431FA8Q30157747-91481B4E-3FCB-4B91-AD59-3C990ECFD9E5Q30579145-DE917EF2-8FAC-4075-BFED-A7B227824311Q33741210-9DC69D10-A029-4B5A-A50F-2ACB6B07775BQ34091097-D0AE1675-DB76-4D00-A257-1D103C95B79DQ34233935-70F1E782-AD43-4F04-A42B-B83E477D15E6Q34549319-E429D080-3C26-44C6-8325-94C21A576B8CQ34588342-F8FC9D80-CA53-4301-AF41-B3182E7214D3Q34695575-21EDC166-ABEB-4E8B-8743-D6C42B2B72D2Q34807689-9D85A09B-5A20-464F-9390-B1FF5B64A735Q35061520-9124E464-D865-4381-A808-DDE8915DE45AQ35102293-C9D221B4-A264-4F1E-B1A7-986D824C0F59Q35111321-4383A511-5A9D-48B5-BC9C-3D2D74BC2F49Q35515708-56A94709-F344-4B5D-B380-6897FC2478A5Q35562905-81919C2A-E718-4292-80BF-55EB6959A324Q35671956-3A96A760-3272-4377-A147-1ECE0ABF8504Q36670213-E7AFD062-93BF-424B-8C7B-9CF533765677Q36738312-048C0BA8-61AA-4AF9-B895-52E68075119DQ36967153-730264F2-B508-4E8B-977A-12384A478B8EQ37384068-D8691945-D071-4A43-B7C3-C2739691F207Q38031978-2B58E7B0-2146-460E-99A4-88C0AEC75AF9Q38090432-F0712672-FD18-4E4B-BB74-91C328B76A4AQ38372232-869E5DD4-AF64-4700-AC7B-7274531F0519Q38651960-65572E3F-7D9B-4832-826B-34E306B18DA3Q39584394-9A858571-DA92-4EB8-A738-96B0187F4088Q40007351-71B7FB5A-838E-45C0-9CDB-37FFB33ACE58Q40077080-A8EE0956-8FBA-4559-9905-8F97D83517E1Q40101492-6B9CDB09-F45F-4124-9FB4-8E340E5EAD0CQ41979296-173A98D1-16F5-4895-AB0E-97724E7A2F94Q41987298-655C938F-A0F2-4D13-B638-92BC88A65E15Q42813512-79047236-5B06-4813-B1F3-74B3796414E3
P2860
Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence
description
2006 nî lūn-bûn
@nan
2006 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence
@ast
Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence
@en
Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence
@en-gb
Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence
@nl
type
label
Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence
@ast
Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence
@en
Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence
@en-gb
Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence
@nl
prefLabel
Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence
@ast
Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence
@en
Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence
@en-gb
Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence
@nl
P2093
P2860
P356
P1433
P1476
Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence
@en
P2093
Andres Alonso
Changjun Zhu
Christine Louis-dit-Sully
Fabio Cerignoli
Michel Moutschen
Rachel Henkens
Souad Rahmouni
Tomas Mustelin
Toshiya Tsutji
P2860
P2888
P304
P356
10.1038/NCB1398
P407
P577
2006-05-01T00:00:00Z
P5875
P6179
1047789237