Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a
about
The p16(INK4a) tumour suppressor protein inhibits alphavbeta3 integrin-mediated cell spreading on vitronectin by blocking PKC-dependent localization of alphavbeta3 to focal contacts.Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzymeStructure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structureStructural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinaseThe JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loopCrystal structure of a 12 ANK repeat stack from human ankyrinR.Analysis of ankyrin repeats reveals how a single point mutation in RFXANK results in bare lymphocyte syndromeCAK-independent activation of CDK6 by a viral cyclinRegulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1)Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors7SK snRNA: a noncoding RNA that plays a major role in regulating eukaryotic transcriptionThe ankyrin repeat as molecular architecture for protein recognitionTumor suppressor INK4: refinement of p16INK4A structure and determination of p15INK4B structure by comparative modeling and NMR dataTargeting CDK6 in cancer: State of the art and new insightsThe other side of the coin: the tumor-suppressive aspect of oncogenes and the oncogenic aspect of tumor-suppressive genes, such as those along the CCND-CDK4/6-RB axisStructure-based design of p18INK4c proteins with increased thermodynamic stability and cell cycle inhibitory activityX-ray crystal structure of an IkappaBbeta x NF-kappaB p65 homodimer complexThe crystal structure of gankyrin, an oncoprotein found in complexes with cyclin-dependent kinase 4, a 19 S proteasomal ATPase regulator, and the tumor suppressors Rb and p53Structure and stability of the ankyrin domain of the Drosophila Notch receptorCrystal structure of the homolog of the oncoprotein gankyrin, an interactor of Rb and CDK4/6A systematic interaction map of validated kinase inhibitors with Ser/Thr kinasesStructure of the archaeal Kae1/Bud32 fusion protein MJ1130: a model for the eukaryotic EKC/KEOPS subcomplexSequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lockGenetic and biochemical interactions among Yar1, Ltv1 and Rps3 define novel links between environmental stress and ribosome biogenesis in Saccharomyces cerevisiae.A cyclin D-Cdk4 activity required for G2 phase cell cycle progression is inhibited in ultraviolet radiation-induced G2 phase delayThe INK4 family of cell cycle inhibitors in cancercdk6 can shorten G(1) phase dependent upon the N-terminal INK4 interaction domainIdentification of novel point mutations in ERK2 that selectively disrupt binding to MEK1Identification of a cyclin T-binding domain in Hexim1 and biochemical analysis of its binding competition with HIV-1 TatCyclin-dependent kinase 11(p58) interacts with HBO1 and enhances its histone acetyltransferase activityCyclin D1: polymorphism, aberrant splicing and cancer riskSingle amino acid substitutions on the surface of Escherichia coli maltose-binding protein can have a profound impact on the solubility of fusion proteinsCyclin-dependent kinase-like function is shared by the beta- and gamma- subset of the conserved herpesvirus protein kinasesCDK6 kinase activity is required for thymocyte developmentHistone deacetylase 3 (HDAC3) participates in the transcriptional repression of the p16 (INK4a) gene in mammary gland of the female rat offspring exposed to an early-life high-fat dietCloning and characterization of diacylglycerol kinase iota splice variants in rat brainCharacterization of a high-molecular-weight Notch complex in the nucleus of Notch(ic)-transformed RKE cells and in a human T-cell leukemia cell line.Functional evaluation of tumour-specific variants of p16INK4a/CDKN2A: correlation with protein structure information.Overview of protein structural and functional folds.A coiled-coil enabled split-luciferase three-hybrid system: applied toward profiling inhibitors of protein kinases.
P2860
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P2860
Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a
description
1998 nî lūn-bûn
@nan
1998 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
name
Structural basis for inhibitio ...... the tumour suppressor p16INK4a
@ast
Structural basis for inhibitio ...... the tumour suppressor p16INK4a
@en
Structural basis for inhibitio ...... the tumour suppressor p16INK4a
@en-gb
Structural basis for inhibitio ...... the tumour suppressor p16INK4a
@nl
type
label
Structural basis for inhibitio ...... the tumour suppressor p16INK4a
@ast
Structural basis for inhibitio ...... the tumour suppressor p16INK4a
@en
Structural basis for inhibitio ...... the tumour suppressor p16INK4a
@en-gb
Structural basis for inhibitio ...... the tumour suppressor p16INK4a
@nl
prefLabel
Structural basis for inhibitio ...... the tumour suppressor p16INK4a
@ast
Structural basis for inhibitio ...... the tumour suppressor p16INK4a
@en
Structural basis for inhibitio ...... the tumour suppressor p16INK4a
@en-gb
Structural basis for inhibitio ...... the tumour suppressor p16INK4a
@nl
P2093
P3181
P356
P1433
P1476
Structural basis for inhibitio ...... the tumour suppressor p16INK4a
@en
P2093
P2888
P304
P3181
P356
10.1038/26155
P407
P577
1998-09-17T00:00:00Z
P6179
1034157082