The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer
about
The holo-apoptosome: activation of procaspase-9 and interactions with caspase-3Molecular mechanisms of inflammasome activation during microbial infectionsRegulation of the intrinsic apoptosis pathway by reactive oxygen speciesMinnelide: a novel therapeutic that promotes apoptosis in non-small cell lung carcinoma in vivoDNA IR-Double Strand Breaks (DSBs) and cellular response via ATMDefective molecular timer in the absence of nucleotides leads to inefficient caspase activationCaspase-9: structure, mechanisms and clinical applicationDifferential sensitivity to apoptosome apparatus activation in non-small cell lung carcinoma and the lungMitochondrial and postmitochondrial survival signaling in cancer.From computational modelling of the intrinsic apoptosis pathway to a systems-based analysis of chemotherapy resistance: achievements, perspectives and challenges in systems medicine.Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation.The caspase-8 homolog Dredd cleaves Imd and Relish but is not inhibited by p35Regulation of the Apaf-1-caspase-9 apoptosomecIAP1 cooperatively inhibits procaspase-3 activation by the caspase-9 apoptosomeA systems biology analysis of apoptosome formation and apoptosis execution supports allosteric procaspase-9 activationIntra- and interdimeric caspase-8 self-cleavage controls strength and timing of CD95-induced apoptosis.Activation of caspase-9, but not caspase-2 or caspase-8, is essential for heat-induced apoptosis in Jurkat cells.Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung cancer cells.Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome.The apoptosome at high resolution.Structural determinants of caspase-9 inhibition by the vaccinia virus protein, F1LResveratrol induces p53-independent, X-linked inhibitor of apoptosis protein (XIAP)-mediated Bax protein oligomerization on mitochondria to initiate cytochrome c release and caspase activation.Inhibitor of apoptosis (IAP)-like protein lacks a baculovirus IAP repeat (BIR) domain and attenuates cell death in plant and animal systemsUp-regulation of VEGF and its receptor in refractory leukemia cells.Alpinetin inhibits lung cancer progression and elevates sensitization drug-resistant lung cancer cells to cis-diammined dichloridoplatium.Inhibition of caspase-9 by stabilized peptides targeting the dimerization interface.Proteolytic processing of the caspase-9 zymogen is required for apoptosome-mediated activation of caspase-9Effects of copper sulfate-oxidized or myeloperoxidase-modified LDL on lipid loading and programmed cell death in macrophages under hypoxia.A near atomic structure of the active human apoptosome.A Complex between Atg7 and Caspase-9: A NOVEL MECHANISM OF CROSS-REGULATION BETWEEN AUTOPHAGY AND APOPTOSIS.Structural biology of the intrinsic cell death pathway: what do we know and what is missing?Regulation of Apoptosis by Inhibitors of Apoptosis (IAPs)Molecules that modulate Apaf-1 activity.Regulation of DNA fragmentation: the role of caspases and phosphorylation.Apoptosome structure, assembly, and procaspase activation.Cellular mechanisms controlling caspase activation and function.Mitochondrial regulation of cell death.Cell death controlling complexes and their potential therapeutic role.Deletion mutational analysis of BMRP, a pro-apoptotic protein that binds to Bcl-2.Cell Death Signaling.
P2860
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P2860
The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer
description
2009 nî lūn-bûn
@nan
2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
The Apaf-1*procaspase-9 apopto ...... teolytic-based molecular timer
@ast
The Apaf-1*procaspase-9 apopto ...... teolytic-based molecular timer
@en
The Apaf-1*procaspase-9 apopto ...... teolytic-based molecular timer
@en-gb
The Apaf-1*procaspase-9 apopto ...... teolytic-based molecular timer
@nl
type
label
The Apaf-1*procaspase-9 apopto ...... teolytic-based molecular timer
@ast
The Apaf-1*procaspase-9 apopto ...... teolytic-based molecular timer
@en
The Apaf-1*procaspase-9 apopto ...... teolytic-based molecular timer
@en-gb
The Apaf-1*procaspase-9 apopto ...... teolytic-based molecular timer
@nl
prefLabel
The Apaf-1*procaspase-9 apopto ...... teolytic-based molecular timer
@ast
The Apaf-1*procaspase-9 apopto ...... teolytic-based molecular timer
@en
The Apaf-1*procaspase-9 apopto ...... teolytic-based molecular timer
@en-gb
The Apaf-1*procaspase-9 apopto ...... teolytic-based molecular timer
@nl
P2093
P2860
P3181
P356
P1433
P1476
The Apaf-1*procaspase-9 apopto ...... teolytic-based molecular timer
@en
P2093
Howard O Fearnhead
Madhavi Challa-Malladi
Shawn B Bratton
Srinivas Malladi
P2860
P304
P3181
P356
10.1038/EMBOJ.2009.152
P407
P577
2009-07-08T00:00:00Z