The Cdc42 effector IRSp53 generates filopodia by coupling membrane protrusion with actin dynamics
about
Cdc42 interaction with N-WASP and Toca-1 regulates membrane tubulation, vesicle formation and vesicle motility: implications for endocytosissrGAP2 arginine methylation regulates cell migration and cell spreading through promoting dimerizationPinkbar is an epithelial-specific BAR domain protein that generates planar membrane structuresInsulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF(U) during pedestal formationRegulation of IRSp53-dependent filopodial dynamics by antagonism between 14-3-3 binding and SH3-mediated localization.CDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASPThe F-BAR domain of srGAP2 induces membrane protrusions required for neuronal migration and morphogenesisPCP Signaling between Migrating Neurons and their Planar-Polarized Neuroepithelial Environment Controls Filopodial Dynamics and Directional MigrationStructural basis for complex formation between human IRSp53 and the translocated intimin receptor Tir of enterohemorrhagic E. coli.Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectorsDynamic filopodia are required for chemokine-dependent intracellular polarization during guided cell migration in vivoThe insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticityPostsynaptic distribution of IRSp53 in spiny excitatory and inhibitory neuronsIRSp53 mediates podosome formation via VASP in NIH-Src cells.The BAR Domain Superfamily Proteins from Subcellular Structures to Human DiseasesCurvature recognition and force generation in phagocytosis.F-BAR domain proteins: Families and function.The proposed functions of membrane curvatures mediated by the BAR domain superfamily proteins.The Toca-1-N-WASP complex links filopodial formation to endocytosisDynamin1 is a novel target for IRSp53 protein and works with mammalian enabled (Mena) protein and Eps8 to regulate filopodial dynamics.Cdc42 and RhoA reveal different spatio-temporal dynamics upon local stimulation with Semaphorin-3A.Inhibition of Rho-associated kinases disturbs the collective cell migration of stratified TE-10 cellsCoordination of membrane and actin cytoskeleton dynamics during filopodia protrusion.Rho GTPase Cdc42 is a direct interacting partner of Adenomatous Polyposis Coli protein and can alter its cellular localizationControl of cortical rigidity by the cytoskeleton: emerging roles for septins.Plasticity-related gene 5 promotes spine formation in murine hippocampal neurons.PtdIns (3,4,5) P3 recruitment of Myo10 is essential for axon developmentThe F-BAR domain of SRGP-1 facilitates cell-cell adhesion during C. elegans morphogenesisS-nitrosylation of cofilin-1 mediates estradiol-17β-stimulated endothelial cytoskeleton remodeling.mDia1 and WAVE2 proteins interact directly with IRSp53 in filopodia and are involved in filopodium formationSH2B1 orchestrates signaling events to filopodium formation during neurite outgrowth.Actin nucleation and elongation factors: mechanisms and interplay.Determination of in vivo dissociation constant, KD, of Cdc42-effector complexes in live mammalian cells using single wavelength fluorescence cross-correlation spectroscopy.Differential identity of Filopodia and Tunneling Nanotubes revealed by the opposite functions of actin regulatory complexes.Redundant functions of I-BAR family members, IRSp53 and IRTKS, are essential for embryonic development.Actin machinery and mechanosensitivity in invadopodia, podosomes and focal adhesions.A large scale Huntingtin protein interaction network implicates Rho GTPase signaling pathways in Huntington disease.Regulation of the actin cytoskeleton-plasma membrane interplay by phosphoinositides.Formin' cellular structures: Physiological roles of Diaphanous (Dia) in actin dynamics.Phosphoinositide-binding interface proteins involved in shaping cell membranes.
P2860
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P2860
The Cdc42 effector IRSp53 generates filopodia by coupling membrane protrusion with actin dynamics
description
2008 nî lūn-bûn
@nan
2008 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
The Cdc42 effector IRSp53 gene ...... protrusion with actin dynamics
@ast
The Cdc42 effector IRSp53 gene ...... protrusion with actin dynamics
@en
The Cdc42 effector IRSp53 gene ...... protrusion with actin dynamics
@en-gb
The Cdc42 effector IRSp53 gene ...... protrusion with actin dynamics
@nl
type
label
The Cdc42 effector IRSp53 gene ...... protrusion with actin dynamics
@ast
The Cdc42 effector IRSp53 gene ...... protrusion with actin dynamics
@en
The Cdc42 effector IRSp53 gene ...... protrusion with actin dynamics
@en-gb
The Cdc42 effector IRSp53 gene ...... protrusion with actin dynamics
@nl
prefLabel
The Cdc42 effector IRSp53 gene ...... protrusion with actin dynamics
@ast
The Cdc42 effector IRSp53 gene ...... protrusion with actin dynamics
@en
The Cdc42 effector IRSp53 gene ...... protrusion with actin dynamics
@en-gb
The Cdc42 effector IRSp53 gene ...... protrusion with actin dynamics
@nl
P2093
P2860
P356
P1476
The Cdc42 effector IRSp53 gene ...... protrusion with actin dynamics
@en
P2093
Esther Koh
Kim Buay Lim
Siew Hwa Ong
Sohail Ahmed
Thankiah Sudhaharan
Wah Ing Goh
P2860
P304
P356
10.1074/JBC.M710185200
P407
P577
2008-07-18T00:00:00Z