Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion
about
VRK1 interacts with p53 forming a basal complex that is activated by UV-induced DNA damageMutant p53: One, No One, and One Hundred ThousandProtein-protein interaction networks: probing disease mechanisms using model systemsInteraction of p53 with the CCT complex promotes protein folding and wild-type p53 activityHow do oncoprotein mutations rewire protein-protein interaction networks?Misfolding, Aggregation, and Disordered Segments in c-Abl and p53 in Human Cancer.Mutant TP53 posttranslational modifications: challenges and opportunities.Comparison of modules of wild type and mutant Huntingtin and TP53 protein interaction networks: implications in biological processes and functions.Dynamics of DNA damage induced pathways to cancerIntrinsic disorder mediates hepatitis C virus core-host cell protein interactions.NRD1, which encodes nardilysin protein, promotes esophageal cancer cell invasion through induction of MMP2 and MMP3 expression.Proteome-wide analysis of mutant p53 targets in breast cancer identifies new levels of gain-of-function that influence PARP, PCNA, and MCM4.A systematic review and meta-analysis of somatic and germline DNA sequence biomarkers of esophageal cancer survival, therapy response and stage.Regulation of nucleotide metabolism by mutant p53 contributes to its gain-of-function activities.Mutant p53-R273H mediates cancer cell survival and anoikis resistance through AKT-dependent suppression of BCL2-modifying factor (BMF).A novel TP53 pathway influences the HGS-mediated exosome formation in colorectal cancer.Inhibition of glucosylceramide synthase eliminates the oncogenic function of p53 R273H mutant in the epithelial-mesenchymal transition and induced pluripotency of colon cancer cells.Nardilysin in human brain diseases: both friend and foe.Edgotype: a fundamental link between genotype and phenotype.TP53 mutants in the tower of babel of cancer progression.Mutant p53 in cancer: new functions and therapeutic opportunities.Broader implications of SILAC-based proteomics for dissecting signaling dynamics in cancer.p53 regulates cytoskeleton remodeling to suppress tumor progression.Mutant p53 upregulates alpha-1 antitrypsin expression and promotes invasion in lung cancer.Oncogenic Mutant p53 Gain of Function Nourishes the Vicious Cycle of Tumor Development and Cancer Stem-Cell Formation.Interactomic approach for evaluating nucleophosmin-binding proteins as biomarkers for Ewing's sarcoma.Cancer-specific mutations in p53 induce the translation of Δ160p53 promoting tumorigenesis.SMG7 is a critical regulator of p53 stability and function in DNA damage stress response.Identification of Associated Proteins by Immunoprecipitation and Mass Spectrometry Analysis.Proteomic identification of ERP29 as a key chemoresistant factor activated by the aggregating p53 mutant Arg282Trp.Li-Fraumeni Syndrome Disease Model: A Platform to Develop Precision Cancer Therapy Targeting Oncogenic p53.Potential therapeutic targets of TP53 gene in the context of its classically canonical functions and its latest non-canonical functions in human cancer.Wild-type p53 oligomerizes more efficiently than p53 hot-spot mutants and overcomes mutant p53 gain-of-function via a "dominant-positive" mechanism
P2860
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P248
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P2860
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion
description
2012 nî lūn-bûn
@nan
2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Mutant p53 interactome identif ...... partner that promotes invasion
@ast
Mutant p53 interactome identif ...... partner that promotes invasion
@en
Mutant p53 interactome identif ...... partner that promotes invasion
@en-gb
Mutant p53 interactome identif ...... partner that promotes invasion
@nl
type
label
Mutant p53 interactome identif ...... partner that promotes invasion
@ast
Mutant p53 interactome identif ...... partner that promotes invasion
@en
Mutant p53 interactome identif ...... partner that promotes invasion
@en-gb
Mutant p53 interactome identif ...... partner that promotes invasion
@nl
prefLabel
Mutant p53 interactome identif ...... partner that promotes invasion
@ast
Mutant p53 interactome identif ...... partner that promotes invasion
@en
Mutant p53 interactome identif ...... partner that promotes invasion
@en-gb
Mutant p53 interactome identif ...... partner that promotes invasion
@nl
P2093
P2860
P3181
P356
P1433
P1476
Mutant p53 interactome identif ...... partner that promotes invasion
@en
P2093
Chit Fang Cheok
Hue Kian Oh
Jayantha Gunaratne
Karen H Vousden
Kelly A Hogue
Patricia A J Muller
Suat Peng Neo
Walter P Blackstock
P2860
P304
P3181
P356
10.1038/EMBOR.2012.74
P407
P577
2012-06-29T00:00:00Z