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Structural basis of substrate discrimination and integrin binding by autotaxin

Structural basis of substrate discrimination and integrin binding by autotaxin

http://www.wikidata.org/entity/Q24337236

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Role of the autotaxin-lysophosphatidate axis in cancer resistance to chemotherapy and radiotherapy Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling Structural basis for specific inhibition of Autotaxin by a DNA aptamer Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling Autotaxin: structure-function and signaling Autotaxin-lysophosphatidic acid axis is a novel molecular target for lowering intraocular pressure A metabolically-stabilized phosphonate analog of lysophosphatidic acid attenuates collagen-induced arthritis A novel highly potent autotaxin/ENPP2 inhibitor produces prolonged decreases in plasma lysophosphatidic acid formation in vivo and regulates urethral tension Identification and biochemical characterization of an acid sphingomyelinase-like protein from the bacterial plant pathogen Ralstonia solanacearum that hydrolyzes ATP to AMP but not sphingomyelin to ceramide The Bulk of Autotaxin Activity Is Dispensable for Adult Mouse Life P2Y12 receptor expression is a critical determinant of functional responsiveness to ATX's MORFO domain Target highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure prediction Mechanism of rapid elimination of lysophosphatidic acid and related lipids from the circulation of mice.Integrin-mediated cell surface recruitment of autotaxin promotes persistent directional cell migration.Targeting the hydrophobic pocket of autotaxin with virtual screening of inhibitors identifies a common aromatic sulfonamide structural motif.Dysregulation of lysophosphatidic acids in multiple sclerosis and autoimmune encephalomyelitis.Lysophosphatidic acid receptor 5 inhibits B cell antigen receptor signaling and antibody response Cellular function and molecular structure of ecto-nucleotidases.Computational identification and experimental characterization of substrate binding determinants of nucleotide pyrophosphatase/phosphodiesterase 7.Lysophosphatidic acid in atherosclerotic diseases Interaction of platelet-derived autotaxin with tumor integrin αVβ3 controls metastasis of breast cancer cells to bone.Non-invasive imaging of tumors by monitoring autotaxin activity using an enzyme-activated near-infrared fluorogenic substrate.Aromatic phosphonates inhibit the lysophospholipase D activity of autotaxin Non-cell autonomous and non-catalytic activities of ATX in the developing brain Binding of autotaxin to integrins localizes lysophosphatidic acid production to platelets and mammalian cells.Kinetic analysis of autotaxin reveals substrate-specific catalytic pathways and a mechanism for lysophosphatidic acid distribution Lysophospholipid mediators in the vasculature Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors.Ligand-based autotaxin pharmacophore models reflect structure-based docking results.Phospholipase D: enzymology, functionality, and chemical modulation Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1 Chemical evolution of autotaxin inhibitors Vinyl sulfone analogs of lysophosphatidylcholine irreversibly inhibit autotaxin and prevent angiogenesis in melanoma.Autotaxin, a lysophospholipase D with pleomorphic effects in oncogenesis and cancer progression Autotaxin through lysophosphatidic acid stimulates polarization, motility, and transendothelial migration of naive T cells Homology modeling and docking studies of ENPP4: a BCG activated tumoricidal macrophage protein.Structure and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase Controlling cancer through the autotaxin-lysophosphatidic acid receptor axis.HIV-1 Tat Inhibits Autotaxin Lysophospholipase D Activity and Modulates Oligodendrocyte Differentiation Autotaxin production of lysophosphatidic acid mediates allergic asthmatic inflammation.

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Structural basis of substrate discrimination and integrin binding by autotaxin

http://www.wikidata.org/entity/Q24337236

description

2011 nî lūn-bûn

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2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի փետրվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Structural basis of substrate discrimination and integrin binding by autotaxin

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Structural basis of substrate discrimination and integrin binding by autotaxin

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Structural basis of substrate discrimination and integrin binding by autotaxin

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Structural basis of substrate discrimination and integrin binding by autotaxin

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Structural basis of substrate discrimination and integrin binding by autotaxin

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Structural basis of substrate discrimination and integrin binding by autotaxin

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Structural basis of substrate discrimination and integrin binding by autotaxin

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Structural basis of substrate discrimination and integrin binding by autotaxin

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Structural basis of substrate discrimination and integrin binding by autotaxin

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Structural basis of substrate discrimination and integrin binding by autotaxin

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Structural basis of substrate discrimination and integrin binding by autotaxin

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Structural basis of substrate discrimination and integrin binding by autotaxin

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Nature Structural & Molecular Biology

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Structural basis of substrate discrimination and integrin binding by autotaxin

@en

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Andrew J Morris

http://www.w3.org/2001/XMLSchema#string

Anna J S Houben

http://www.w3.org/2001/XMLSchema#string

Craig W Vander Kooi

http://www.w3.org/2001/XMLSchema#string

Harald M H G Albers

http://www.w3.org/2001/XMLSchema#string

Jacqueline E Day

http://www.w3.org/2001/XMLSchema#string

Jens Hausmann

http://www.w3.org/2001/XMLSchema#string

Leonie van Zeijl

http://www.w3.org/2001/XMLSchema#string

Lyle E Pegg

http://www.w3.org/2001/XMLSchema#string

Maria Andries

http://www.w3.org/2001/XMLSchema#string

Mobien Kasiem

http://www.w3.org/2001/XMLSchema#string

P2860

Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein

Functional structure of the somatomedin B domain of vitronectin

MSDmotif: exploring protein sites and motifs

Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production

MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

How vitronectin binds PAI-1 to modulate fibrinolysis and cell migration

Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes

Inference of macromolecular assemblies from crystalline state

Coot: model-building tools for molecular graphics

Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions

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198-204

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scholarly article

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2322582

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10.1038/NSMB.1980

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P433

2

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18

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Anastassis Perrakis

Laurens A van Meeteren

Evangelos Christodoulou

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2011-02-01T00:00:00Z

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49760519

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1003001956

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21240271

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phosphatidylcholine catabolic process

Ectonucleotide pyrophosphatase/phosphodiesterase 2

structural biology

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3064516

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