Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes - Wikidata - wikimedia - TriplyDB

Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes

Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes

http://www.wikidata.org/entity/Q24337370

about

In the light of directed evolution: pathways of adaptive protein evolution Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities Structural basis of the γ-lactone-ring formation in ascorbic acid biosynthesis by the senescence marker protein-30/gluconolactonase The structure of Rauvolfia serpentina strictosidine synthase is a novel six-bladed beta-propeller fold in plant proteins Paraoxonase 1 (PON1) as a genetic determinant of susceptibility to organophosphate toxicity Risk of brain tumors in children and susceptibility to organophosphorus insecticides: the potential role of paraoxonase (PON1).Antioxidant properties of HDL The human paraoxonase gene cluster as a target in the treatment of atherosclerosis Library methods for structural biology of challenging proteins and their complexes Caenorhabditis elegans paraoxonase-like proteins control the functional expression of DEG/ENaC mechanosensory proteins.Structural and mutational analyses of Drp35 from Staphylococcus aureus: a possible mechanism for its lactonase activity Rapid determination of hydrogen positions and protonation states of diisopropyl fluorophosphatase by joint neutron and X-ray diffraction refinement Ancestral mutations as a tool for solubilizing proteins: The case of a hydrophobic phosphate-binding protein Sequence conservation of apolipoprotein A-I affords novel insights into HDL structure-function The 'evolvability' of promiscuous protein functions Paraoxonases as potential antibiofilm agents: their relationship with quorum-sensing signals in Gram-negative bacteria Associations of maternal organophosphate pesticide exposure and PON1 activity with birth outcomes in SAWASDEE birth cohort, Thailand Human paraoxonase-1 (PON1): Gene structure and expression, promiscuous activities and multiple physiological roles One enzyme, two functions: PON2 prevents mitochondrial superoxide formation and apoptosis independent from its lactonase activity Modulation of paraoxonase 1 and 3 expression after moderate exercise training in the rat Paraoxonase 1 and homocysteine metabolism.In vivo administration of BL-3050: highly stable engineered PON1-HDL complexes Incorporating Synthetic Oligonucleotides via Gene Reassembly (ISOR): a versatile tool for generating targeted libraries.Hydrolysis of DFP and the nerve agent (S)-sarin by DFPase proceeds along two different reaction pathways: implications for engineering bioscavengers.Homocysteinethiolactone and paraoxonase: novel markers of diabetic retinopathy.Effects of PON polymorphisms and haplotypes on molecular phenotype in Mexican-American mothers and children.Quorum quenching enzyme activity is widely conserved in the sera of mammalian species.New insights about enzyme evolution from large scale studies of sequence and structure relationships.Paraoxonase 2 deficiency alters mitochondrial function and exacerbates the development of atherosclerosis Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease.Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase.Engineering human PON1 in an E. coli expression system.Mechanistic Insights into the Hydrolysis of Organophosphorus Compounds by Paraoxonase-1: Exploring the Limits of Substrate Tolerance in a Promiscuous Enzyme.Lead exposure is associated with decreased serum paraoxonase 1 (PON1) activity and genotypes Paraoxonase (PON1 and PON3) Polymorphisms: Impact on Liver Expression and Atorvastatin-Lactone Hydrolysis Paraoxonase 2 serves a proapopotic function in mouse and human cells in response to the Pseudomonas aeruginosa quorum-sensing molecule N-(3-Oxododecanoyl)-homoserine lactone.Low levels of serum paraoxonase activities are characteristic of metabolic syndrome and may influence the metabolic-syndrome-related risk of coronary artery disease.Correlation of serum arylesterase activity on phenylacetate estimated by the integrated method to common classical biochemical indexes of liver damage Assessing the prediction fidelity of ancestral reconstruction by a library approach.An Engineered Version of Human PON2 Opens the Way to Understand the Role of Its Post-Translational Modifications in Modulating Catalytic Activity.

P2860

427f821e91c601bbdd33d761e29dfc15d28196d9 cae7bf5e372eb2bbcec2401811f6912e0b3a71fb

P248

Q22066327-EA4E405B-F39E-4144-8FD9-C50803CE9F93 Q24298200-0B00F4FC-C5CA-4B9B-96E3-EA54FE9152A3 Q24311507-7D99EC40-EBA5-4B2F-AEC9-7F4827DF625C Q24542391-809C0F8C-FE8D-4D99-AA2F-BA1169A23EB8 Q24602455-C02DAACA-CE6E-4A59-8367-94654727F748 Q24813657-7F5B7BD6-4798-4123-989C-97274EE82790 Q26777244-BBA05528-5730-4AEA-B446-67AAA9079B34 Q26824356-24033886-3D8C-4DA0-A26D-1E099C2B9114 Q27008422-C31A4927-1C16-4760-B461-A6FBF79CFF2D Q27305177-23CB8C92-F051-443F-BD87-79BD3A2BE311 Q27643299-1381F466-E0FC-4636-BA72-775681A3FAC5 Q27653388-F0599298-505E-4E37-BBA4-E8C97479B407 Q27681569-64EC26F4-6E92-4E62-B676-43A6A942A039 Q27690671-1C6BE713-9EC5-46D7-8226-FE8AC9491541 Q28295483-9D1FF293-6F82-48E7-AF0D-69C0613969D3 Q28302221-5191DB8E-F7D3-4CCE-919D-72AE701B3A94 Q28391428-F207AF93-E772-4FCD-87A2-3BB02335F677 Q28395898-9A761C23-9E23-4208-83EC-2F039933AEFD Q28397498-C1DFD7FC-F450-4BD9-99BA-A771E728BDB2 Q28566625-190051B9-82EF-46E0-AC6B-EC4B917909C9 Q30417352-A485C7CB-9975-4A9E-AA59-A7421D8454D4 Q30891417-A47EF9B8-9251-408C-84B5-7F314BEB1B9D Q33283855-AA047009-070B-4FCC-B648-C1E37BE1E1D7 Q33567108-20AC1273-8137-4EA7-B494-1E838F882F35 Q34084584-4BA4D000-D6DB-4168-88E7-CA41C29480D5 Q34414287-B6296B9F-0FD8-4CAE-B13F-85CF4557C3CD Q34427327-AEC54E67-DAE7-4C22-92A9-2F066450381F Q34430858-773646CC-87A7-4AE1-8E6F-9F4AA69651DA Q34447321-500C2AED-5BD4-4C73-A67F-1601DDCF200F Q34556739-0D352C28-C9D3-4404-B04E-DE46D18B8580 Q34602695-BB4F1753-9A5C-480D-9203-C23FE92F9BD3 Q34669205-F7271BCC-AEF7-4975-A9F8-4D6BC3F3C292 Q34942229-D60D450D-F5B7-4433-8D08-39F21DB1CE08 Q35001794-AB05E671-5808-4D5C-BEC7-CD601F5CF217 Q35138221-BF0EE952-B246-4EF6-AE77-5938ED0B4BDC Q35172698-769B32F6-3D1C-4368-A054-C93FBFF7612C Q35231847-CA410FB9-21AF-494B-81CE-CFDE7A61A2E1 Q35722932-2E5B4A0D-6BA8-496E-83D7-D771EE4E1D14 Q35746785-6EC56A09-EECA-490E-93EB-981C58E9F8E3 Q35866267-AC03839C-746A-4E3E-AF2E-AF88016121DC

P2860

Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes

http://www.wikidata.org/entity/Q24337370

description

2004 nî lūn-bûn

@nan

2004 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2004年の論文

@ja

2004年論文

@yue

2004年論文

@zh-hant

2004年論文

@zh-hk

2004年論文

@zh-mo

2004年論文

@zh-tw

2004年论文

@wuu

name

Structure and evolution of the ...... d anti-atherosclerotic enzymes

@ast

Structure and evolution of the ...... d anti-atherosclerotic enzymes

@en

Structure and evolution of the ...... d anti-atherosclerotic enzymes

@en-gb

Structure and evolution of the ...... d anti-atherosclerotic enzymes

@nl

type

label

Structure and evolution of the ...... d anti-atherosclerotic enzymes

@ast

Structure and evolution of the ...... d anti-atherosclerotic enzymes

@en

Structure and evolution of the ...... d anti-atherosclerotic enzymes

@en-gb

Structure and evolution of the ...... d anti-atherosclerotic enzymes

@nl

prefLabel

Structure and evolution of the ...... d anti-atherosclerotic enzymes

@ast

Structure and evolution of the ...... d anti-atherosclerotic enzymes

@en

Structure and evolution of the ...... d anti-atherosclerotic enzymes

@en-gb

Structure and evolution of the ...... d anti-atherosclerotic enzymes

@nl

P1433

Q24337370-78B9144B-AC74-4C5A-9FB4-FC64231D8ED4

P1476

Q24337370-70145B7F-A93E-43BA-B561-25B0F5EA73FE

P2093

Q24337370-09E60B7A-5369-4710-B645-95F5AEFF702E

Q24337370-150DF727-BE83-4338-8A01-DA17278602A7

Q24337370-233EFBDC-C8A7-4A97-83DA-367F088202F5

Q24337370-438218F8-0749-4818-9981-78CD150A6998

Q24337370-5016730C-3912-4146-96B4-EBC8E1EB8AB1

Q24337370-53226AED-D5E8-47D7-B0C0-76D9930E45F4

Q24337370-63C8A015-41E2-4C34-BB47-20CBDA47FBAB

Q24337370-82C28737-E250-4108-B4FB-AEACD438FD35

Q24337370-9AED7A32-D643-4106-A089-F32C8F5075B5

Q24337370-F0B9610B-C646-4F11-9665-D35C6CED9FC5

P2860

Q24337370-00C9BA92-BD5F-4A6E-932F-E9A41DF11AB1

Q24337370-02BF0A35-407E-4339-8E83-CACDFFE8FD29

Q24337370-0735A379-064F-4741-B7F0-C0518C2047D9

Q24337370-172BC5A0-3F4C-47CE-87B2-7CF3C5BE2EF6

Q24337370-2484AA16-2C20-4B4E-8C00-7425692169B3

Q24337370-2AE37833-A6E1-4387-88E7-D7B5D5EC76A1

Q24337370-46F47BE5-B7C9-44AA-AE8A-D0673299D8CA

Q24337370-509E2251-DB0D-46FA-9281-1CAF24AC14B4

Q24337370-54502E48-355E-4628-A5BC-7AF4A0004ABA

Q24337370-61FDD5EA-8F3C-46BB-8609-2133F88D2A07

P2888

Q24337370-6167827A-5F00-42A8-80E1-ADD3388FBE5E

P304

Q24337370-408205F9-8F33-4F39-B46C-52D9D87B66B5

P31

Q24337370-0502158C-D53E-4F09-ABD6-2C1537FAF09C

P3181

Q24337370-AB47C52C-4697-45B2-86A0-E98105DE3FF9

P356

Q24337370-CC5DCEE2-2E23-43D8-ADC4-9C8617FA19A2

P407

Q24337370-DAB5EDD2-D1AD-4068-9C21-BB42A37CCDC9

P433

Q24337370-AD3BADE7-3550-40E3-AD7B-C3EBDBE47B0A

P478

Q24337370-27901E0C-5244-457D-8A93-CFD9788954C6

P50

Q24337370-5F6A9BBF-697F-4D30-81FF-597E5F7FED6D

Q24337370-E87F29EA-964F-4664-9180-FF4119626562

P577

Q24337370-D3C2A7C1-4B53-44A1-8ABD-23E9183C01F7

P5875

Q24337370-CDBAB9F4-0135-43BD-9D26-E622A1D8F6BF

P6179

Q24337370-542A5809-2FF1-466C-AA34-13011A102A91

P698

Q24337370-B8E010D3-5147-4D7A-BE6E-E440030411BA

P921

Q24337370-56562074-BF00-4FC8-9132-AB47EB122E20

Q24337370-75FB17DC-1215-44E1-BCC7-C57E093EFDE9

Q24337370-D573D225-9372-4547-947E-0E7B1272589C

P3181

P356

P1433

Nature Structural & Molecular Biology

P1476

Structure and evolution of the ...... d anti-atherosclerotic enzymes

@en

P2093

Amir Aharoni

http://www.w3.org/2001/XMLSchema#string

Andrew McCarthy

http://www.w3.org/2001/XMLSchema#string

Boris Brumshtein

http://www.w3.org/2001/XMLSchema#string

Dan S Tawfik

http://www.w3.org/2001/XMLSchema#string

Hay Dvir

http://www.w3.org/2001/XMLSchema#string

Leonid Gaidukov

http://www.w3.org/2001/XMLSchema#string

Lilly Toker

http://www.w3.org/2001/XMLSchema#string

Michal Harel

http://www.w3.org/2001/XMLSchema#string

Olga Khersonsky

http://www.w3.org/2001/XMLSchema#string

Raimond B G Ravelli

http://www.w3.org/2001/XMLSchema#string

P2860

Human serum Paraoxonase/Arylesterase's retained hydrophobic N-terminal leader sequence associates with HDLs by binding phospholipids : apolipoprotein A-I stabilizes activity

Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization

Atherosclerosis

Crystal structure of diisopropylfluorophosphatase from Loligo vulgaris

Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme

Phospholipase A2 engineering. Structural and functional roles of the highly conserved active site residue aspartate-99

Crystal structure of truncated human apolipoprotein A-I suggests a lipid-bound conformation

The interpretation of protein structures: estimation of static accessibility

Human paraoxonase-3 is an HDL-associated enzyme with biological activity similar to paraoxonase-1 protein but is not regulated by oxidized lipids

Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis

P2888

P304

412-9

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

1595463

http://www.w3.org/2001/XMLSchema#string

P356

10.1038/NSMB767

http://www.w3.org/2001/XMLSchema#string

P407

P433

5

http://www.w3.org/2001/XMLSchema#string

P478

11

http://www.w3.org/2001/XMLSchema#string

P50

Joel L. Sussman

P577

2004-05-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

8606374

http://www.w3.org/2001/XMLSchema#string

P6179

1021652905

http://www.w3.org/2001/XMLSchema#string

P698

15098021

http://www.w3.org/2001/XMLSchema#string

P921

atherosclerosis

calcium ion binding