Inhibition of basal FGF receptor signaling by dimeric Grb2
about
RHEX, a novel regulator of human erythroid progenitor cell expansion and erythroblast developmentStructure of FGFR3 Transmembrane Domain Dimer: Implications for Signaling and Human PathologiesGenetic insights into the mechanisms of Fgf signalingGrb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancerCharacterization of membrane protein interactions in plasma membrane derived vesicles with quantitative imaging Förster resonance energy transferGrb2 carboxyl-terminal SH3 domain can bivalently associate with two ligands, in an SH3 dependent manner.GRB2 Nucleates T Cell Receptor-Mediated LAT Clusters That Control PLC-γ1 Activation and Cytokine Production.Competition between Grb2 and Plcγ1 for FGFR2 regulates basal phospholipase activity and invasion.Allostery mediates ligand binding to Grb2 adaptor in a mutually exclusive manner.Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli.Binding and function of phosphotyrosines of the Ephrin A2 (EphA2) receptor using synthetic sterile α motif (SAM) domains.Pro-oncogenic function of HIP-55/Drebrin-like (DBNL) through Ser269/Thr291-phospho-sensor motifs.Fine-tuning T cell receptor signaling to control T cell developmentMicroscale thermophoresis quantifies biomolecular interactions under previously challenging conditionsPotent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA.The Fibroblast Growth Factor signaling pathwayThe ability of Sos1 to oligomerize the adaptor protein LAT is separable from its guanine nucleotide exchange activity in vivo.Adaptor protein GRB2 promotes Src tyrosine kinase activation and podosomal organization by protein-tyrosine phosphatase ϵ in osteoclasts.Cannabinoid receptor 1 promotes hepatocellular carcinoma initiation and progression through multiple mechanisms.Grb2 monomer-dimer equilibrium determines normal versus oncogenic function.FRAP, FLIM, and FRET: Detection and analysis of cellular dynamics on a molecular scale using fluorescence microscopy.EphA2 Receptor Unliganded Dimers Suppress EphA2 Pro-tumorigenic Signaling.RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth.Unliganded EphA3 dimerization promoted by the SAM domain.VEGFR-2 conformational switch in response to ligand binding.Grb2, a double-edged sword of receptor tyrosine kinase signalingQuercetin targets the interaction of calcineurin with LxVP-type motifs in immunosuppression.Grb2 promotes integrin-induced focal adhesion kinase (FAK) autophosphorylation and directs the phosphorylation of protein tyrosine phosphatase α by the Src-FAK kinase complex.Fully quantified spectral imaging reveals in vivo membrane protein interactions.Current Experimental Methods for Characterizing Protein-Protein Interactions.Heparin modulates the mitogenic activity of fibroblast growth factor by inducing dimerization of its receptor. a 3D view by using NMR.Effect of the achondroplasia mutation on FGFR3 dimerization and FGFR3 structural response to fgf1 and fgf2: A quantitative FRET study in osmotically derived plasma membrane vesicles.Copy-number variants and candidate gene mutations in isolated split hand/foot malformation.Antibody-induced dimerization of FGFR1 promotes receptor endocytosis independently of its kinase activity.FGFR3 unliganded dimer stabilization by the juxtamembrane domain.Unliganded fibroblast growth factor receptor 1 forms density-independent dimers.Mechanism of FGF receptor dimerization and activation.A small peptide promotes EphA2 kinase-dependent signaling by stabilizing EphA2 dimers.Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity.Ubiquitination of basal VEGFR2 regulates signal transduction and endothelial function.
P2860
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P2860
Inhibition of basal FGF receptor signaling by dimeric Grb2
description
2012 nî lūn-bûn
@nan
2012 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Inhibition of basal FGF receptor signaling by dimeric Grb2
@ast
Inhibition of basal FGF receptor signaling by dimeric Grb2
@en
Inhibition of basal FGF receptor signaling by dimeric Grb2
@en-gb
Inhibition of basal FGF receptor signaling by dimeric Grb2
@nl
type
label
Inhibition of basal FGF receptor signaling by dimeric Grb2
@ast
Inhibition of basal FGF receptor signaling by dimeric Grb2
@en
Inhibition of basal FGF receptor signaling by dimeric Grb2
@en-gb
Inhibition of basal FGF receptor signaling by dimeric Grb2
@nl
prefLabel
Inhibition of basal FGF receptor signaling by dimeric Grb2
@ast
Inhibition of basal FGF receptor signaling by dimeric Grb2
@en
Inhibition of basal FGF receptor signaling by dimeric Grb2
@en-gb
Inhibition of basal FGF receptor signaling by dimeric Grb2
@nl
P2093
P3181
P1433
P1476
Inhibition of basal FGF receptor signaling by dimeric Grb2
@en
P2093
Chi-Chuan Lin
Fernando A Melo
John Kirkpatrick
Kin M Suen
Loren J Stagg
Ragini Ghosh
Zamal Ahmed
P304
P3181
P356
10.1016/J.CELL.2012.04.033
P407
P577
2012-06-22T00:00:00Z