Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity - Wikidata - wikimedia - TriplyDB

Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity

Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity

http://www.wikidata.org/entity/Q24523292

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Acute overactive endocannabinoid signaling induces glucose intolerance, hepatic steatosis, and novel cannabinoid receptor 1 responsive genes Is lipid signaling through cannabinoid 2 receptors part of a protective system?The endocannabinoid system as an emerging target of pharmacotherapy Heavy marijuana users show increased serum apolipoprotein C-III levels: evidence from proteomic analyses Activation of the peripheral endocannabinoid system in human obesity The orphan receptor GPR55 is a novel cannabinoid receptor A biosynthetic pathway for anandamide Prevalence, predisposition and prevention of type II diabetes.Cannabinoid receptor type-1: breaking the dogmas High Times for Painful Blues: The Endocannabinoid System in Pain-Depression Comorbidity Minireview: From the bench, toward the clinic: therapeutic opportunities for cannabinoid receptor modulation The hepatic cannabinoid 1 receptor as a modulator of hepatic energy state and food intake Chemical probes of endocannabinoid metabolism The thrifty lipids: endocannabinoids and the neural control of energy conservation The role of endocannabinoids system in fatty liver disease and therapeutic potentials Cannabis Smoking and Diabetes Mellitus: Results from Meta-analysis with Eight Independent Replication Samples.Endocannabinoid regulation of β-cell functions: implications for glycaemic control and diabetes Krill products: an overview of animal studies The endocannabinoid system: directing eating behavior and macronutrient metabolism Dietary linoleic acid elevates endogenous 2-AG and anandamide and induces obesity Obesity, the endocannabinoid system, and bias arising from pharmaceutical sponsorship The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome The CB1 antagonist rimonabant decreases insulin hypersecretion in rat pancreatic islets Causality of small and large intestinal microbiota in weight regulation and insulin resistance Obesity: Current and potential pharmacotherapeutics and targets.The endocannabinoid system: a new pharmacological target for obesity treatment?Photoperiodic changes in endocannabinoid levels and energetic responses to altered signalling at CB1 receptors in Siberian hamsters.Potential role of the endocannabinoid receptor antagonist rimonabant in the management of cardiometabolic risk: a narrative review of available data Effect of dietary krill oil supplementation on the endocannabinoidome of metabolically relevant tissues from high-fat-fed mice.Biomarkers of endocannabinoid system activation in severe obesity Cannabinoid CB1 receptor overactivity contributes to the pathogenesis of idiopathic pulmonary fibrosis.Endocannabinoid receptors gene expression in morbidly obese women with nonalcoholic fatty liver disease.Cannabis use is associated with reduced prevalence of non-alcoholic fatty liver disease: A cross-sectional study.Regulation of MAP kinase-directed mitogenic and protein kinase B-mediated signaling by cannabinoid receptor type 1 in skeletal muscle cells Role of thiazolidinediones, insulin sensitizers, in non-alcoholic fatty liver disease Fatty Acid Binding Protein-1 (FABP1) and the Human FABP1 T94A Variant: Roles in the Endocannabinoid System and Dyslipidemias.Metabolite profiling identifies anandamide as a biomarker of nonalcoholic steatohepatitis.De novo lipogenesis and stearoyl-CoA desaturase are coordinately regulated in the human adipocyte and protect against palmitate-induced cell injury.Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: involvement of regulatory T cells.Cannabinoids as novel anti-inflammatory drugs.

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Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity

http://www.wikidata.org/entity/Q24523292

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Douglas Osei-Hyiaman

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George Kunos

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Jie Liu

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Judith Harvey-White

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Ken Mackie

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Lei Wang

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László Offertáler

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Michael DePetrillo

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Pál Pacher

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Svetlana Radaeva

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P2860

Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase

Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats

Regulation of phospholipid biosynthesis in isolated rat hepatocytes. Effect of different substrates

Leptin-regulated endocannabinoids are involved in maintaining food intake

CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity

Hormonal regulation of mouse fatty acid synthase gene transcription in liver

Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice

Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production

The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells

Metabolism of anandamide and 2-arachidonoylglycerol: an historical overview and some recent developments.

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1298-305

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10.1172/JCI23057

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115

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15864349

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endocannabinoids

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1087161

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