The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein
about
Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex.A novel cervical cancer suppressor 3 (CCS-3) interacts with the BTB domain of PLZF and inhibits the cell growth by inducing apoptosisKaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promotersThe transcriptional co-repressor myeloid translocation gene 16 inhibits glycolysis and stimulates mitochondrial respirationETO2 coordinates cellular proliferation and differentiation during erythropoiesisETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domainOligomerization of ETO is obligatory for corepressor interactionPLZF is a negative regulator of retinoic acid receptor transcriptional activityHistone deacetylases as targets for treatment of multiple diseasesStructural basis for the assembly of the SMRT/NCoR core transcriptional repression machinerySolution Structure of the mSin3A PAH2–Pf1 SID1 Complex: A Mad1/Mxd1-Like Interaction Disrupted by MRG15 in the Rpd3S/Sin3S ComplexThe transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignanciesThe LIM-only protein DRAL/FHL2 interacts with and is a corepressor for the promyelocytic leukemia zinc finger proteinPDCD2 is a negative regulator of HCF-1 (C1)Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteinsHistone deacetylases and cancerThe leukemia associated ETO nuclear repressor gene is regulated by the GATA-1 transcription factor in erythroid/megakaryocytic cells.Myeloid translocation gene 16 (MTG16) interacts with Notch transcription complex components to integrate Notch signaling in hematopoietic cell fate specificationEndothelial angiogenesis is directed by RUNX1T1-regulated VEGFA, BMP4 and TGF-β2 expressionHistone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein.AML1-ETO fusion protein up-regulates TRKA mRNA expression in human CD34+ cells, allowing nerve growth factor-induced expansion.In-depth mutational analysis of the promyelocytic leukemia zinc finger BTB/POZ domain reveals motifs and residues required for biological and transcriptional functions.Dichotomy of AML1-ETO functions: growth arrest versus block of differentiationCritical residues within the BTB domain of PLZF and Bcl-6 modulate interaction with corepressors.AML1 and the AML1-ETO fusion protein in the pathogenesis of t(8;21) AML.Common themes in the pathogenesis of acute myeloid leukemia.Translocations of the RARalpha gene in acute promyelocytic leukemia.Transcriptional regulation in acute promyelocytic leukemia.Nuclear receptor corepressor complexes in cancer: mechanism, function and regulationThe novel BTB/POZ and zinc finger factor Zbtb45 is essential for proper glial differentiation of neural and oligodendrocyte progenitor cellsGrowth suppression by acute promyelocytic leukemia-associated protein PLZF is mediated by repression of c-myc expressionRunx1t1 (Runt-related transcription factor 1; translocated to, 1) epigenetically regulates the proliferation and nitric oxide production of microgliaMyeloid translocation gene 16 is required for maintenance of haematopoietic stem cell quiescence.Predicting the effect of transcription therapy in hematologic malignancies.Myeloid translocation gene family members associate with T-cell factors (TCFs) and influence TCF-dependent transcription.The promyelocytic leukemia zinc finger protein down-regulates apoptosis and expression of the proapoptotic BID protein in lymphocytesETO, but not leukemogenic fusion protein AML1/ETO, augments RBP-Jkappa/SHARP-mediated repression of notch target genesDeletion of Mtg16, a target of t(16;21), alters hematopoietic progenitor cell proliferation and lineage allocation.Large-scale identification of disease genes involved in acute myeloid leukemiaPromyelocytic leukemia zinc finger protein regulates interferon-mediated innate immunity
P2860
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P2860
The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein
description
2000 nî lūn-bûn
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2000年の論文
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2000年論文
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2000年論文
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name
The ETO protein disrupted in t ...... c leukemia zinc finger protein
@ast
The ETO protein disrupted in t ...... c leukemia zinc finger protein
@en
The ETO protein disrupted in t ...... c leukemia zinc finger protein
@en-gb
The ETO protein disrupted in t ...... c leukemia zinc finger protein
@nl
type
label
The ETO protein disrupted in t ...... c leukemia zinc finger protein
@ast
The ETO protein disrupted in t ...... c leukemia zinc finger protein
@en
The ETO protein disrupted in t ...... c leukemia zinc finger protein
@en-gb
The ETO protein disrupted in t ...... c leukemia zinc finger protein
@nl
prefLabel
The ETO protein disrupted in t ...... c leukemia zinc finger protein
@ast
The ETO protein disrupted in t ...... c leukemia zinc finger protein
@en
The ETO protein disrupted in t ...... c leukemia zinc finger protein
@en-gb
The ETO protein disrupted in t ...... c leukemia zinc finger protein
@nl
P2093
P2860
P1476
The ETO protein disrupted in t ...... c leukemia zinc finger protein
@en
P2093
A M Melnick
A Polinger
B Lutterbach
G W Carlile
J J Westendorf
S W Hiebert
P2860
P304
P356
10.1128/MCB.20.6.2075-2086.2000
P407
P50
P577
2000-03-01T00:00:00Z