Lowe syndrome protein OCRL1 interacts with clathrin and regulates protein trafficking between endosomes and the trans-Golgi network
about
A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPasesSpecific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathwaysOCRL localizes to the primary cilium: a new role for cilia in Lowe syndromeThe PH domain proteins IPIP27A and B link OCRL1 to receptor recycling in the endocytic pathwayA PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolismA role of the Lowe syndrome protein OCRL in early steps of the endocytic pathwayTwo closely related endocytic proteins that share a common OCRL-binding motif with APPL1Differential clathrin binding and subcellular localization of OCRL1 splice isoformsOCRL1 function in renal epithelial membrane trafficAll known patient mutations in the ASH-RhoGAP domains of OCRL affect targeting and APPL1 bindingSubversion of Cell-Autonomous Immunity and Cell Migration by Legionella pneumophila EffectorsThe cellular and physiological functions of the Lowe syndrome protein OCRL1Inositol polyphosphate 5-phosphatases; new players in the regulation of cilia and ciliopathiesPhosphoinositides: tiny lipids with giant impact on cell regulationPhosphoinositides in the mammalian endo-lysosomal networkOCRL1 engages with the F-BAR protein pacsin 2 to promote biogenesis of membrane-trafficking intermediates.Combined proteomic and metabonomic studies in three genetic forms of the renal Fanconi syndromeRecent advances in retromer biologyThe phox domain of sorting nexin 5 lacks phosphatidylinositol 3-phosphate (PtdIns(3)P) specificity and preferentially binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)Interaction of Rab31 and OCRL-1 in oligodendrocytes: its role in transport of mannose 6-phosphate receptorsCrystal structure of the Rab binding domain of OCRL1 in complex with Rab8 and functional implications of the OCRL1/Rab8 module for Lowe syndromeRenal phenotype in Lowe Syndrome: a selective proximal tubular dysfunctionAGAP2 regulates retrograde transport between early endosomes and the TGNImpaired neural development in a zebrafish model for Lowe syndromeSNX15 links clathrin endocytosis to the PtdIns3P early endosome independently of the APPL1 endosome.Multiple host proteins that function in phosphatidylinositol-4-phosphate metabolism are recruited to the chlamydial inclusion.The machinery at endoplasmic reticulum-plasma membrane contact sites contributes to spatial regulation of multiple Legionella effector proteins.Phosphoinositide phosphatases in cell biology and disease.Lowe Syndrome protein OCRL1 supports maturation of polarized epithelial cells.Hereditary causes of kidney stones and chronic kidney diseaseSpecies-specific difference in expression and splice-site choice in Inpp5b, an inositol polyphosphate 5-phosphatase paralogous to the enzyme deficient in Lowe SyndromeMouse model for Lowe syndrome/Dent Disease 2 renal tubulopathy.A role of OCRL in clathrin-coated pit dynamics and uncoating revealed by studies of Lowe syndrome cells.The Lowe syndrome protein OCRL1 is required for endocytosis in the zebrafish pronephric tubule.Phosphoinositides and vesicular membrane trafficSuppression of intestinal calcium entry channel TRPV6 by OCRL, a lipid phosphatase associated with Lowe syndrome and Dent disease.Rab GTPases implicated in inherited and acquired disorders.An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway.The 5-phosphatase OCRL mediates retrograde transport of the mannose 6-phosphate receptor by regulating a Rac1-cofilin signalling module.
P2860
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P2860
Lowe syndrome protein OCRL1 interacts with clathrin and regulates protein trafficking between endosomes and the trans-Golgi network
description
2005 nî lūn-bûn
@nan
2005 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Lowe syndrome protein OCRL1 in ...... es and the trans-Golgi network
@ast
Lowe syndrome protein OCRL1 in ...... es and the trans-Golgi network
@en
Lowe syndrome protein OCRL1 in ...... es and the trans-Golgi network
@nl
type
label
Lowe syndrome protein OCRL1 in ...... es and the trans-Golgi network
@ast
Lowe syndrome protein OCRL1 in ...... es and the trans-Golgi network
@en
Lowe syndrome protein OCRL1 in ...... es and the trans-Golgi network
@nl
prefLabel
Lowe syndrome protein OCRL1 in ...... es and the trans-Golgi network
@ast
Lowe syndrome protein OCRL1 in ...... es and the trans-Golgi network
@en
Lowe syndrome protein OCRL1 in ...... es and the trans-Golgi network
@nl
P2093
P2860
P356
P1476
Lowe syndrome protein OCRL1 in ...... es and the trans-Golgi network
@en
P2093
Agnes Saint-Pol
Athanasios Konstantakopoulos
Catrin Williams
Evan Eisenberg
Fang Zhang
John Lucocq
Lois E Greene
Ludger Johannes
Martin Lowe
P2860
P304
P356
10.1091/MBC.E05-02-0120
P407
P577
2005-05-25T00:00:00Z