Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity
about
Polo-like kinase 3 is required for entry into S phasePlk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alphaCalcium- and integrin-binding protein 1 regulates microtubule organization and centrosome segregation through polo like kinase 3 during cell cycle progressionPolo box domain of Plk3 functions as a centrosome localization signal, overexpression of which causes mitotic arrest, cytokinesis defects, and apoptosisHyperosmotic stress-induced ATF-2 activation through Polo-like kinase 3 in human corneal epithelial cellsPlk3 interacts with and specifically phosphorylates VRK1 in Ser342, a downstream target in a pathway that induces Golgi fragmentationCalcium-dependent inhibition of polo-like kinase 3 activity by CIB1 in breast cancer cellsBcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpointsPlk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppressionCalcium- and integrin-binding protein 1 regulates endomitosis and its interaction with Polo-like kinase 3 is enhanced in endomitotic Dami cellsSAK, a new polo-like kinase, is transcriptionally repressed by p53 and induces apoptosis upon RNAi silencingRole of Plk2 (Snk) in mouse development and cell proliferationCalcium- and integrin-binding protein 1 regulates megakaryocyte ploidy, adhesion, and migrationRegulation of PTEN stability and activity by Plk3Polo-like kinases and the orchestration of cell divisionCaspase-2-mediated cell death is required for deleting aneuploid cells.Transcriptome analysis reveals potential mechanisms underlying differential heart development in fast- and slow-growing broilers under heat stress.Mice deficient in the serine/threonine protein kinase VRK1 are infertile due to a progressive loss of spermatogonia.Polo-box domain: a versatile mediator of polo-like kinase function.Hormonal induction of polo-like kinases (Plks) and impact of Plk2 on cell cycle progression in the rat ovary.Effect of hypoxic stress-activated Polo-like kinase 3 on corneal epithelial wound healingPolo-like kinases and centrosome regulation.Hyperosmotic stress-induced corneal epithelial cell death through activation of Polo-like kinase 3 and c-Jun.Attenuated monocyte apoptosis, a new mechanism for osteoporosis suggested by a transcriptome-wide expression study of monocytesThe mammalian centrosome and its functional significancePolo-like kinase isoform expression is a prognostic factor in ovarian carcinoma.Activation of Polo-like kinase 3 by hypoxic stresses.Polo-like kinase 3 functions as a tumor suppressor and is a negative regulator of hypoxia-inducible factor-1 alpha under hypoxic conditions.Cytoskeletal architecture and cell motility remain unperturbed in mouse embryonic fibroblasts from Plk3 knockout mice.Stimulation of polo-like kinase 3 mRNA decay by tristetraprolin.ER-Golgi network--a future target for anti-cancer therapy.Effects of low doses of ionizing radiation exposures on stress-responsive gene expression in human embryonic stem cells.Targeting of polo-like kinases and their cross talk with Aurora kinases--possible therapeutic strategies in human acute myeloid leukemia?Current assessment of polo-like kinases as anti-tumor drug targets.Polo-like kinases: structural variations lead to multiple functions.The role of Plk3 in oncogenesis.Ligand stimulation of CD95 induces activation of Plk3 followed by phosphorylation of caspase-8.Polo-like kinases inhibited by wortmannin. Labeling site and downstream effects.Function of polo-like kinase 3 in NF-kappaB-mediated proapoptotic response.Serum inducible kinase is a positive regulator of cortical dendrite development and is required for BDNF-promoted dendritic arborization.
P2860
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P2860
Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity
description
2002 nî lūn-bûn
@nan
2002 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Cell cycle arrest and apoptosi ...... ation of microtubule integrity
@ast
Cell cycle arrest and apoptosi ...... ation of microtubule integrity
@en
Cell cycle arrest and apoptosi ...... ation of microtubule integrity
@nl
type
label
Cell cycle arrest and apoptosi ...... ation of microtubule integrity
@ast
Cell cycle arrest and apoptosi ...... ation of microtubule integrity
@en
Cell cycle arrest and apoptosi ...... ation of microtubule integrity
@nl
prefLabel
Cell cycle arrest and apoptosi ...... ation of microtubule integrity
@ast
Cell cycle arrest and apoptosi ...... ation of microtubule integrity
@en
Cell cycle arrest and apoptosi ...... ation of microtubule integrity
@nl
P2093
P2860
P921
P3181
P1476
Cell cycle arrest and apoptosi ...... ation of microtubule integrity
@en
P2093
Kenji Fukasawa
Meena Jhanwar-Uniyal
Suqing Xie
Ulhas Naik
P2860
P304
P3181
P356
10.1128/MCB.22.10.3450-3459.2002
P407
P577
2002-05-01T00:00:00Z