Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms. - Wikidata - wikimedia - TriplyDB

Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms.

Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms.

http://www.wikidata.org/entity/Q24537454

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The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex Similar effects of all WNK3 variants on SLC12 cotransporters WNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathway SLC26A9 is a Cl(-) channel regulated by the WNK kinases The thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKs Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members Domains of WNK1 kinase in the regulation of ROMK1 Mutations in the nervous system--specific HSN2 exon of WNK1 cause hereditary sensory neuropathy type II WNK kinases, renal ion transport and hypertension Regulation of ROMK channel and K+ homeostasis by kidney-specific WNK1 kinase Intersectin links WNK kinases to endocytosis of ROMK1 Regulatory Crosstalk by Protein Kinases on CFTR Trafficking and Activity.Calcium-sensing receptor decreases cell surface expression of the inwardly rectifying K+ channel Kir4.1 Decrease in dietary K intake stimulates the generation of superoxide anions in the kidney and inhibits K secretory channels in the CCD A SPAK isoform switch modulates renal salt transport and blood pressure POSH stimulates the ubiquitination and the clathrin-independent endocytosis of ROMK1 channels.Emerging Targets of Diuretic Therapy.Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion.WNK4 kinase stimulates caveola-mediated endocytosis of TRPV5 amplifying the dynamic range of regulation of the channel by protein kinase C Non-pharmacological aspects of blood pressure management: what are the data?Decreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension.Comprehensive assessment of the association of WNK4 polymorphisms with hypertension: evidence from a meta-analysis.MicroRNA-194 (miR-194) regulates ROMK channel activity by targeting intersectin 1.WNK kinases and renal sodium transport in health and disease: an integrated view.Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse models The WNKs: atypical protein kinases with pleiotropic actions.Distal convoluted tubule WNK4-mediated regulation of renal ion transport proteins.WNK1 kinase isoform switch regulates renal potassium excretion.Activation of PI3-kinase stimulates endocytosis of ROMK via Akt1/SGK1-dependent phosphorylation of WNK1.Recent advances in distal tubular potassium handling Differential regulation of ROMK (Kir1.1) in distal nephron segments by dietary potassium Identification and functional characterization of Kir2.6 mutations associated with non-familial hypokalemic periodic paralysis.WNK4 kinase inhibits Maxi K channel activity by a kinase-dependent mechanism.Cardiovascular expression of the mouse WNK1 gene during development and adulthood revealed by a BAC reporter assay.WNK1 activates large-conductance Ca2+-activated K+ channels through modulation of ERK1/2 signaling.Src-family protein tyrosine kinase phosphorylates WNK4 and modulates its inhibitory effect on KCNJ1 (ROMK).Overexpression of the sodium chloride cotransporter is not sufficient to cause familial hyperkalemic hypertension.Association of urinary sodium/potassium ratio with blood pressure: sex and racial differences.WNK4 inhibits NCC protein expression through MAPK ERK1/2 signaling pathway.

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P2860

Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms.

http://www.wikidata.org/entity/Q24537454

description

2006 nî lūn-bûn

@nan

2006 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2006 թվականի հունվարին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms

@nl

Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms.

@ast

Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms.

@en

type

label

Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms

@nl

Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms.

@ast

Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms.

@en

prefLabel

Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms

@nl

Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms.

@ast

Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms.

@en

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PNAS.0510609103

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms.

@en

P2093

Ahmed Lazrak

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Chou-Long Huang

http://www.w3.org/2001/XMLSchema#string

Zhen Liu

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P2860

A new locus on chromosome 12p13.3 for pseudohypoaldosteronism type II, an autosomal dominant form of hypertension

Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4

WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia

Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoform

Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins

Dynamin mediates caveolar sequestration of muscarinic cholinergic receptors and alteration in NO signaling

WNK kinases, a novel protein kinase subfamily in multi-cellular organisms

Regulation of WNK1 by an autoinhibitory domain and autophosphorylation

Human hypertension caused by mutations in WNK kinases

NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor

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1615-1620

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scholarly article

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10.1073/PNAS.0510609103

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5

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103

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2006-01-20T00:00:00Z

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7345148

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16428287

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1360592

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