Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development - Wikidata - wikimedia - TriplyDB

Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development

Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development

http://www.wikidata.org/entity/Q24537650

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Individual CREB-target genes dictate usage of distinct cAMP-responsive coactivation mechanisms Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B cells Protein lysine acetylation by p300/CBP Structural basis for recruitment of CBP/p300 coactivators by STAT1 and STAT2 transactivation domains Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to coactivator CBP Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation Genetic interaction between mutations in c-Myb and the KIX domains of CBP and p300 affects multiple blood cell lineages and influences both gene activation and repression NF-Y is essential for expression of the proapoptotic bim gene in sympathetic neurons T-cells null for the MED23 subunit of mediator express decreased levels of KLF2 and inefficiently populate the peripheral lymphoid organs Histone acetyl transferases CBP and p300 are necessary for maintenance of renin cell identity and transformation of smooth muscle cells to the renin phenotype.CBP and p300 are essential for renin cell identity and morphological integrity of the kidney.Subregion-specific p300 conditional knock-out mice exhibit long-term memory impairments.TLX1/HOX11-induced hematopoietic differentiation blockade.Mutational inhibition of c-Myb or p300 ameliorates treatment-induced thrombocytopenia Regulation of iNOS gene transcription by IL-1β and IFN-γ requires a coactivator exchange mechanism.Presenilin controls CBP levels in the adult Drosophila central nervous system.Control of B cell development by the histone H2A deubiquitinase MYSM1.CBP is required for environmental enrichment-induced neurogenesis and cognitive enhancement.Transcription coactivators p300 and CBP are necessary for photoreceptor-specific chromatin organization and gene expression.Prepaying the entropic cost for allosteric regulation in KIX Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation.Transcriptional coactivator CBP upregulates hTERT expression and tumor growth and predicts poor prognosis in human lung cancers Transcriptional control of erythropoiesis: emerging mechanisms and principles.CREBBP mutations in relapsed acute lymphoblastic leukaemia.Hippocampal focal knockout of CBP affects specific histone modifications, long-term potentiation, and long-term memory.Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control MicroRNA 132 alters sleep and varies with time in brain.Two histone/protein acetyltransferases, CBP and p300, are indispensable for Foxp3+ T-regulatory cell development and function Identification and computational analysis of gene regulatory elements.Transgenic mice expressing an inhibitory truncated form of p300 exhibit long-term memory deficits.Is histone acetylation the most important physiological function for CBP and p300?Distinct embryonic expression and localization of CBP and p300 histone acetyltransferases at the mouse alphaA-crystallin locus in lens.Mammalian alteration/deficiency in activation 3 (Ada3) is essential for embryonic development and cell cycle progression.Genetic and epigenetic mechanisms of gene regulation during lens development.Involvement of GR and p300 in the induction of H6PD by cortisol in human amnion fibroblasts.Live-cell studies of p300/CBP histone acetyltransferase activity and inhibition Regulation of c-Maf and αA-Crystallin in Ocular Lens by Fibroblast Growth Factor Signaling.Differential binding modes of the bromodomains of CREB-binding protein (CBP) and p300 with acetylated MyoD p300 is not required for metabolic adaptation to endurance exercise training.Transglutaminase 2 protects against ischemic insult, interacts with HIF1beta, and attenuates HIF1 signaling

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Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development

http://www.wikidata.org/entity/Q24537650

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2006 nî lūn-bûn

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2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2006 թվականի փետրվարին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Conditional knockout mice reve ...... and p300 in T-cell development

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Conditional knockout mice reve ...... and p300 in T-cell development

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Conditional knockout mice reve ...... and p300 in T-cell development

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Conditional knockout mice reve ...... and p300 in T-cell development

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Conditional knockout mice reve ...... and p300 in T-cell development

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Conditional knockout mice reve ...... and p300 in T-cell development

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Conditional knockout mice reve ...... and p300 in T-cell development

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Conditional knockout mice reve ...... and p300 in T-cell development

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Conditional knockout mice reve ...... and p300 in T-cell development

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MCB.26.3.789-809.2006

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Molecular and Cellular Biology

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Conditional knockout mice reve ...... and p300 in T-cell development

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Antoine de Pauw

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Caili Tong

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Jan M A van Deursen

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Lawryn H Kasper

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Michelle A Biesen

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Peter J Murray

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Exogenous expression of a dominant negative RORalpha1 vector in muscle cells impairs differentiation: RORalpha1 directly interacts with p300 and myoD

Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1

Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3

Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300

The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

Domains of Brn-2 that mediate homodimerization and interaction with general and melanocytic transcription factors

A novel Rb- and p300-binding protein inhibits transactivation by MyoD

A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression

Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM)

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789-809

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scholarly article

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3591892

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10.1128/MCB.26.3.789-809.2006

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3

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Fayçal Boussouar

Tomofusa Fukuyama

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16428436

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1347027

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