Mechanistic analysis of the mitotic kinesin Eg5. - Wikidata - wikimedia - TriplyDB

Mechanistic analysis of the mitotic kinesin Eg5.

Mechanistic analysis of the mitotic kinesin Eg5.

http://www.wikidata.org/entity/Q24540197

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Kinesin-5: cross-bridging mechanism to targeted clinical therapy Monastrol inhibition of the mitotic kinesin Eg5.The conserved L5 loop establishes the pre-powerstroke conformation of the Kinesin-5 motor, eg5 Pathway of ATP hydrolysis by monomeric kinesin Eg5 ATPase mechanism of Eg5 in the absence of microtubules: insight into microtubule activation and allosteric inhibition by monastrol Increased therapeutic potential of an experimental anti-mitotic inhibitor SB715992 by genistein in PC-3 human prostate cancer cell line Coupling of kinesin ATP turnover to translocation and microtubule regulation: one engine, many machines Vik1 modulates microtubule-Kar3 interactions through a motor domain that lacks an active site.ATPase Cycle of the Nonmotile Kinesin NOD Allows Microtubule End Tracking and Drives Chromosome Movement The Structural Basis of Force Generation by the Mitotic Motor Kinesin-5 Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family.A structural model for monastrol inhibition of dimeric kinesin Eg5.Lattice structure of cytoplasmic microtubules in a cultured Mammalian cell.Physical determinants of bipolar mitotic spindle assembly and stability in fission yeast.Kinesin Motor Enzymology: Chemistry, Structure, and Physics of Nanoscale Molecular Machines A novel small-molecule inhibitor reveals a possible role of kinesin-5 in anastral spindle-pole assembly.Modulation of the kinesin ATPase cycle by neck linker docking and microtubule binding.Mechanistic analysis of the Saccharomyces cerevisiae kinesin Kar3 Dimeric Eg5 maintains processivity through alternating-site catalysis with rate-limiting ATP hydrolysis The loop 5 element structurally and kinetically coordinates dimers of the human kinesin-5, Eg5.Microtubule capture by mitotic kinesin centromere protein E (CENP-E).The structural kinetics of switch-1 and the neck linker explain the functions of kinesin-1 and Eg5.Getting in sync with dimeric Eg5. Initiation and regulation of the processive run.Loop L5 assumes three distinct orientations during the ATPase cycle of the mitotic kinesin Eg5: a transient and time-resolved fluorescence study.Functional and molecular characterization for the damp-obstructed rat model in Chinese medicine.Eg5 Inhibitors Have Contrasting Effects on Microtubule Stability and Metaphase Spindle Integrity.Kinesin spindle protein inhibitor SB743921 induces mitotic arrest and apoptosis and overcomes imatinib resistance of chronic myeloid leukemia cells.Synergism between inhibitors of Aurora A and KIF11 overcomes KIF15-dependent drug resistance The Kinesin-5 Chemomechanical Cycle Is Dominated by a Two-heads-bound State.The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry.The yeast kinesin-5 Cin8 interacts with the microtubule in a noncanonical manner.Disjunction of conjoined twins: Cdk1, Cdh1 and separation of centrosomes.A phase I, dose-escalation study of the Eg5-inhibitor EMD 534085 in patients with advanced solid tumors or lymphoma.Docking and rolling, a model of how the mitotic motor Eg5 works.Src family kinase phosphorylation of the motor domain of the human kinesin-5, Eg5.Kinesin family member 11 contributes to the progression and prognosis of human breast cancer.Synergistic Anticancer Effect of Peptide-Docetaxel Nanoassembly Targeted to Tubulin: Toward Development of Dual Warhead Containing Nanomedicine.Fingerprinting differential active site constraints of ATPases

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Mechanistic analysis of the mitotic kinesin Eg5.

http://www.wikidata.org/entity/Q24540197

description

2004 nî lūn-bûn

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2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2004 թվականի հուլիսին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

Mechanistic analysis of the mitotic kinesin Eg5

@nl

Mechanistic analysis of the mitotic kinesin Eg5.

@ast

Mechanistic analysis of the mitotic kinesin Eg5.

@en

Mechanistic analysis of the mitotic kinesin Eg5.

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type

label

Mechanistic analysis of the mitotic kinesin Eg5

@nl

Mechanistic analysis of the mitotic kinesin Eg5.

@ast

Mechanistic analysis of the mitotic kinesin Eg5.

@en

Mechanistic analysis of the mitotic kinesin Eg5.

@en-gb

prefLabel

Mechanistic analysis of the mitotic kinesin Eg5

@nl

Mechanistic analysis of the mitotic kinesin Eg5.

@ast

Mechanistic analysis of the mitotic kinesin Eg5.

@en

Mechanistic analysis of the mitotic kinesin Eg5.

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Journal of Biological Chemistry

P1476

Mechanistic analysis of the mitotic kinesin Eg5.

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P2093

Christopher A Sontag

http://www.w3.org/2001/XMLSchema#string

Jared C Cochran

http://www.w3.org/2001/XMLSchema#string

John J Correia

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Susan P Gilbert

http://www.w3.org/2001/XMLSchema#string

Tarun M Kapoor

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Zoltan Maliga

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P2860

Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

Mutations in the kinesin-like protein Eg5 disrupting localization to the mitotic spindle

Crystal structure of the kinesin motor domain reveals a structural similarity to myosin

All kinesin superfamily protein, KIF, genes in mouse and human

A bipolar kinesin

A "slow" homotetrameric kinesin-related motor protein purified from Drosophila embryos

The bipolar kinesin, KLP61F, cross-links microtubules within interpolar microtubule bundles of Drosophila embryonic mitotic spindles

Opposing motor activities are required for the organization of the mammalian mitotic spindle pole

Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5.

Crystal structure of the mitotic spindle kinesin Eg5 reveals a novel conformation of the neck-linker

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38861-38870

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scholarly article

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10.1074/JBC.M404203200

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37

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279

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8462542

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15247293

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1356567

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