HIRA, the human homologue of yeast Hir1p and Hir2p, is a novel cyclin-cdk2 substrate whose expression blocks S-phase progression
about
HIRIP3 is a nuclear phosphoprotein interacting with and phosphorylated by the serine-threonine kinase CK2FLASH is essential during early embryogenesis and cooperates with p73 to regulate histone gene transcriptionIdentification and functional analysis of a novel cyclin e/cdk2 substrate ankrd17Phosphorylation of stem-loop binding protein (SLBP) on two threonines triggers degradation of SLBP, the sole cell cycle-regulated factor required for regulation of histone mRNA processing, at the end of S phaseMolecular dissection of formation of senescence-associated heterochromatin fociTransforming growth factor-beta induces Cdk2 relocalization to the cytoplasm coincident with dephosphorylation of retinoblastoma tumor suppressor proteinHuman UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells.Targeted mutagenesis of the Hira gene results in gastrulation defects and patterning abnormalities of mesoendodermal derivatives prior to early embryonic lethalityEffect of PTTG on endogenous gene expression in HEK 293 cells.JISTIC: identification of significant targets in cancer.Phosphorylation of p21 in G2/M promotes cyclin B-Cdc2 kinase activity.Senescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust Senescence Associated Heterochromatin Foci.Statistical methods for identifying yeast cell cycle transcription factors.Coupling of DNA synthesis and histone synthesis in S phase independent of cyclin/cdk2 activity.Distinct chromatin signature of histone H3 variant H3.3 in human cells.Identification of novel phosphorylation modification sites in human proteins that originated after the human-chimpanzee divergence.Chromatin assembly factor 1 is essential and couples chromatin assembly to DNA replication in vivo.WEE1 tyrosine kinase, a novel epigenetic modifierDifferent roles of N-terminal and C-terminal halves of HIRA in transcription regulation of cell cycle-related genes that contribute to control of vertebrate cell growth.Cyclin E-CDK2 protein phosphorylates plant homeodomain finger protein 8 (PHF8) and regulates its function in the cell cycle.Separation-of-function mutation in HPC2, a member of the HIR complex in S. cerevisiae, results in derepression of the histone genes but does not confer cryptic TATA phenotypes.Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex.The mitotic Clb cyclins are required to alleviate HIR-mediated repression of the yeast histone genes at the G1/S transition.Chromatin and transcription in yeastDevelopmental and cell cycle regulation of the Drosophila histone locus bodyStructural prediction of the interaction of the tumor suppressor p27KIP1 with cyclin A/CDK2 identifies a novel catalytically relevant determinantFluvastatin inhibits AGE-induced cell proliferation and migration via an ERK5-dependent Nrf2 pathway in vascular smooth muscle cells.Transcriptional activation of histone genes requires NPAT-dependent recruitment of TRRAP-Tip60 complex to histone promoters during the G1/S phase transition.Cyclin E2 induces genomic instability by mechanisms distinct from cyclin E1.Cardiomyocyte-specific conditional knockout of the histone chaperone HIRA in mice results in hypertrophy, sarcolemmal damage and focal replacement fibrosis.When half is not enough: gene expression and dosage in the 22q11 deletion syndrome.Varicella-zoster virus immediate-early 63 protein interacts with human antisilencing function 1 protein and alters its ability to bind histones h3.1 and h3.3.ERK-dependent threonine phosphorylation of EGF receptor modulates receptor downregulation and signalingDifferential regulation of the histone chaperone HIRA during muscle cell differentiation by a phosphorylation switch.Diminished dosage of 22q11 genes disrupts neurogenesis and cortical development in a mouse model of 22q11 deletion/DiGeorge syndrome.Identification of CDK2 substrates in human cell lysates.A Theileria annulata DNA binding protein localized to the host cell nucleus alters the phenotype of a bovine macrophage cell line.Assembly of helper-dependent adenovirus DNA into chromatin promotes efficient gene expression.FLASH degradation in response to UV-C results in histone locus bodies disruption and cell-cycle arrest.Cell cycle regulation by Kaposi's sarcoma-associated herpesvirus K-bZIP: direct interaction with cyclin-CDK2 and induction of G1 growth arrest.
P2860
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P2860
HIRA, the human homologue of yeast Hir1p and Hir2p, is a novel cyclin-cdk2 substrate whose expression blocks S-phase progression
description
2001 nî lūn-bûn
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2001 թուականի Մարտին հրատարակուած գիտական յօդուած
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2001 թվականի մարտին հրատարակված գիտական հոդված
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2001年の論文
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2001年論文
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2001年論文
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2001年論文
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2001年論文
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2001年論文
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2001年论文
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name
HIRA, the human homologue of y ...... ion blocks S-phase progression
@ast
HIRA, the human homologue of y ...... ion blocks S-phase progression
@en
HIRA, the human homologue of y ...... ion blocks S-phase progression
@nl
type
label
HIRA, the human homologue of y ...... ion blocks S-phase progression
@ast
HIRA, the human homologue of y ...... ion blocks S-phase progression
@en
HIRA, the human homologue of y ...... ion blocks S-phase progression
@nl
prefLabel
HIRA, the human homologue of y ...... ion blocks S-phase progression
@ast
HIRA, the human homologue of y ...... ion blocks S-phase progression
@en
HIRA, the human homologue of y ...... ion blocks S-phase progression
@nl
P2093
P2860
P3181
P1476
HIRA, the human homologue of y ...... ion blocks S-phase progression
@en
P2093
D M Nelson
J A DeCaprio
M Lipinski
S Seeholzer
P2860
P304
P3181
P356
10.1128/MCB.21.5.1854-1865.2001
P407
P577
2001-03-01T00:00:00Z