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Regulation of p53 function and stability by phosphorylation

Regulation of p53 function and stability by phosphorylation

http://www.wikidata.org/entity/Q24554530

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Glycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activity Opposite effect of NF-kB and c-Jun N-terminal kinase on p53-independent GADD45 induction by arsenite Acetylation is indispensable for p53 activation The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation p53 downregulates its activating vaccinia-related kinase 1, forming a new autoregulatory loop ZBP-89 promotes growth arrest through stabilization of p53 Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53 Regulation by phosphorylation of the relative affinities of the N-terminal transactivation domains of p53 for p300 domains and Mdm2 Oncogenic Intra-p53 Family Member Interactions in Human Cancers Molecular Mechanisms of p53 Deregulation in Cancer: An Overview in Multiple Myeloma Multiple sites of in vivo phosphorylation in the MDM2 oncoprotein cluster within two important functional domains Phosphorylation and hsp90 binding mediate heat shock stabilization of p53 Ral GTPase down-regulation stabilizes and reactivates p53 to inhibit malignant transformation BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5 Phosphorylation is a regulatory mechanism in apolipoprotein B mRNA editing Apoptosis of haematopoietic cells upon thymidylate synthase inhibition is independent of p53 accumulation and CD95-CD95 ligand interaction Inhibition of p53-dependent transcription by BOX-I phospho-peptide mimetics that bind to p300.Phosphorylation of murine double minute clone 2 (MDM2) protein at serine-267 by protein kinase CK2 in vitro and in cultured cells ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage Activation and activities of the p53 tumour suppressor protein Oxidative stress enhances phosphorylation of p53 in neonatal rat cardiomyocytes Spatiotemporal switch from DeltaNp73 to TAp73 isoforms during nephrogenesis: impact on differentiation gene expression Tumor suppressor SMAR1 activates and stabilizes p53 through its arginine-serine-rich motif High-Fidelity Reprogrammed Human IPSCs Have a High Efficacy of DNA Repair and Resemble hESCs in Their MYC Transcriptional Signature Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage Modes of p53 regulation Therapeutic considerations for Mdm2: not just a one trick pony Post-translational regulation enables robust p53 regulation.Isolation of temperature-sensitive p53 mutations from a comprehensive missense mutation library.EndophilinAs regulate endosomal sorting of BDNF-TrkB to mediate survival signaling in hippocampal neurons.Apoptosis and growth arrest induced by platinum compounds in U2-OS cells reflect a specific DNA damage recognition associated with a different p53-mediated response.Alternative O-glycosylation/O-phosphorylation of serine-16 in murine estrogen receptor beta: post-translational regulation of turnover and transactivation activity.Downregulation of MDM2 stabilizes p53 by inhibiting p53 ubiquitination in response to specific alkylating agents.The C/H3 domain of p300 is required to protect VRK1 and VRK2 from their downregulation induced by p53 ATM activates p53 by regulating MDM2 oligomerization and E3 processivity

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P2860

Regulation of p53 function and stability by phosphorylation

http://www.wikidata.org/entity/Q24554530

description

1999 nî lūn-bûn

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1999 թուականի Մարտին հրատարակուած գիտական յօդուած

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1999 թվականի մարտին հրատարակված գիտական հոդված

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1999年の論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年论文

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name

Regulation of p53 function and stability by phosphorylation

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Regulation of p53 function and stability by phosphorylation

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Regulation of p53 function and stability by phosphorylation

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type

label

Regulation of p53 function and stability by phosphorylation

@ast

Regulation of p53 function and stability by phosphorylation

@en

Regulation of p53 function and stability by phosphorylation

@nl

prefLabel

Regulation of p53 function and stability by phosphorylation

@ast

Regulation of p53 function and stability by phosphorylation

@en

Regulation of p53 function and stability by phosphorylation

@nl

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P1433

Molecular and Cellular Biology

P1476

Regulation of p53 function and stability by phosphorylation

@en

P2093

K H Vousden

http://www.w3.org/2001/XMLSchema#string

M Ashcroft

http://www.w3.org/2001/XMLSchema#string

M H Kubbutat

http://www.w3.org/2001/XMLSchema#string

P2860

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

Mdm2 promotes the rapid degradation of p53

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

Regulation of p53 stability by Mdm2

p53, the cellular gatekeeper for growth and division

WAF1, a potential mediator of p53 tumor suppression

Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53-mediated repression of transcription

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

P304

1751-8

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P31

scholarly article

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3539617

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P356

10.1128/MCB.19.3.1751

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P433

3

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19

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1999-03-01T00:00:00Z

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13266365

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P698

10022862

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P921

phosphorylation

P932

83968

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