Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities - Wikidata - wikimedia - TriplyDB

Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities

Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities

http://www.wikidata.org/entity/Q24555819

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CIN85, a Cbl-interacting protein, is a component of AMAP1-mediated breast cancer invasion machinery ASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasion Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function P53- and mevalonate pathway-driven malignancies require Arf6 for metastasis and drug resistance.ARF6-JIP3/4 regulate endosomal tubules for MT1-MMP exocytosis in cancer invasion.ARF6 promotes the formation of Rac1 and WAVE-dependent ventral F-actin rosettes in breast cancer cells in response to epidermal growth factor The non-catalytic carboxyl-terminal domain of ARFGAP1 regulates actin cytoskeleton reorganization by antagonizing the activation of Rac1 Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?The adaptor protein CIN85 assembles intracellular signaling clusters for B cell activation Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome Autoinhibition of Arf GTPase-activating protein activity by the BAR domain in ASAP1 Autonomous regulation of osteosarcoma cell invasiveness by Wnt5a/Ror2 signaling Centaurin beta1 down-regulates nucleotide-binding oligomerization domains 1- and 2-dependent NF-kappaB activation ACAP-A/B are ArfGAP homologs in dictyostelium involved in sporulation but not in chemotaxis GEFH1 binds ASAP1 and regulates podosome formation Src-dependent phosphorylation of ASAP1 regulates podosomes.High level expression of AMAP1 protein correlates with poor prognosis and survival after surgery of head and neck squamous cell carcinoma patients ASAP1 promotes tumor cell motility and invasiveness, stimulates metastasis formation in vivo, and correlates with poor survival in colorectal cancer patients.Nck adaptor proteins link Tks5 to invadopodia actin regulation and ECM degradation.Regulation of actin cytoskeleton dynamics by Arf-family GTPases.HER2 carboxyl-terminal fragments regulate cell migration and cortactin phosphorylation Small-molecule synergist of the Wnt/beta-catenin signaling pathway.GEP100-Arf6-AMAP1-cortactin pathway frequently used in cancer invasion is activated by VEGFR2 to promote angiogenesis.Engagement of overexpressed Her2 with GEP100 induces autonomous invasive activities and provides a biomarker for metastases of lung adenocarcinoma.Oncogenic Src requires a wild-type counterpart to regulate invadopodia maturation.Cortactin: a multifunctional regulator of cellular invasiveness Podosomes and Invadopodia: Related structures with Common Protein Components that May Promote Breast Cancer Cellular Invasion.Co-overexpression of GEP100 and AMAP1 proteins correlates with rapid local recurrence after breast conservative therapy A pooled shRNA screen for regulators of primary mammary stem and progenitor cells identifies roles for Asap1 and Prox1.A Golgi-based KDELR-dependent signalling pathway controls extracellular matrix degradation Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration.ArfGAPs: key regulators for receptor sorting.Rab5c promotes AMAP1-PRKD2 complex formation to enhance β1 integrin recycling in EGF-induced cancer invasion.Diverse roles for the paxillin family of proteins in cancer.Fbx8 makes Arf6 refractory to function via ubiquitination.Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer.The Arf GTPase-activating Protein, ASAP1, Binds Nonmuscle Myosin 2A to Control Remodeling of the Actomyosin Network Arf GAPs and their interacting proteins.Arf GAPs as regulators of the actin cytoskeleton.

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P2860

Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities

http://www.wikidata.org/entity/Q24555819

description

2005 nî lūn-bûn

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2005 թուականի Մարտին հրատարակուած գիտական յօդուած

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2005 թվականի մարտին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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Expression of AMAP1, an ArfGAP ...... ast cancer invasive activities

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Expression of AMAP1, an ArfGAP ...... ast cancer invasive activities

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Expression of AMAP1, an ArfGAP ...... ast cancer invasive activities

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Expression of AMAP1, an ArfGAP ...... ast cancer invasive activities

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Expression of AMAP1, an ArfGAP ...... ast cancer invasive activities

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Expression of AMAP1, an ArfGAP ...... ast cancer invasive activities

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Expression of AMAP1, an ArfGAP ...... ast cancer invasive activities

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Expression of AMAP1, an ArfGAP ...... ast cancer invasive activities

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Expression of AMAP1, an ArfGAP ...... ast cancer invasive activities

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SJ.EMBOJ.7600588

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The EMBO Journal

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Expression of AMAP1, an ArfGAP ...... ast cancer invasive activities

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Ari Hashimoto

http://www.w3.org/2001/XMLSchema#string

Atsuko Yamada

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Eiji Ogawa

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Hiromi Wada

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Hisataka Sabe

http://www.w3.org/2001/XMLSchema#string

Masaki Morishige

http://www.w3.org/2001/XMLSchema#string

Masashi Adachi

http://www.w3.org/2001/XMLSchema#string

Nariaki Matsuura

http://www.w3.org/2001/XMLSchema#string

Shigeru Hashimoto

http://www.w3.org/2001/XMLSchema#string

Takaki Sakurai

http://www.w3.org/2001/XMLSchema#string

P2860

ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src.

A new paxillin-binding protein, PAG3/Papalpha/KIAA0400, bearing an ADP-ribosylation factor GTPase-activating protein activity, is involved in paxillin recruitment to focal adhesions and cell migration

Identification of a new Pyk2 target protein with Arf-GAP activity

PAG3/Papalpha/KIAA0400, a GTPase-activating protein for ADP-ribosylation factor (ARF), regulates ARF6 in Fcgamma receptor-mediated phagocytosis of macrophages

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

Gene expression profiling predicts clinical outcome of breast cancer

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

Molecular portraits of human breast tumours

Cortactin: coupling membrane dynamics to cortical actin assembly

Evidence that SH2 domains promote processive phosphorylation by protein-tyrosine kinases

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15719014

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