Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases - Wikidata - wikimedia - TriplyDB

Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases

Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases

http://www.wikidata.org/entity/Q24558620

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Deletion of steroid 5 alpha-reductase 2 gene in male pseudohermaphroditism Genetic and pharmacological evidence for more than one human steroid 5 alpha-reductase LY191704: a selective, nonsteroidal inhibitor of human steroid 5 alpha-reductase type 1 Tissue distribution and ontogeny of steroid 5 alpha-reductase isozyme expression Molecular genetics of steroid 5 alpha-reductase 2 deficiency Inhibition of human steroid 5beta-reductase (AKR1D1) by finasteride and structure of the enzyme-inhibitor complex Activity and expression of progesterone metabolizing 5alpha-reductase, 20alpha-hydroxysteroid oxidoreductase and 3alpha(beta)-hydroxysteroid oxidoreductases in tumorigenic (MCF-7, MDA-MB-231, T-47D) and nontumorigenic (MCF-10A) human breast cancer c Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma Targeting cancer using cholesterol conjugates A novel homozygous disruptive mutation in the SRD5A2-gene in a partially virilized patient with 5alpha-reductase deficiency Determination of the 'critical region' for cat-like cry of Cri-du-chat syndrome and analysis of candidate genes by quantitative PCR Finasteride concentrations and prostate cancer risk: results from the Prostate Cancer Prevention Trial Stimulatory effect of insulin on 5alpha-reductase type 1 (SRD5A1) expression through an Akt-dependent pathway in ovarian granulosa cells The isolation of transcription factors from lambda gt11 cDNA expression libraries: human steroid 5 alpha-reductase 1 has sequence-specific DNA binding activity.Challenges in Testosterone Measurement, Data Interpretation, and Methodological Appraisal of Interventional Trials.Transcriptional regulation of the mouse steroid 5alpha-reductase type II gene by progesterone in brain Inhibition of skin 5 alpha-reductase by oral contraceptive progestins in vitro.Characterizing proteins of unknown function: orphan cytochrome p450 enzymes as a paradigm.Inhibition of steroid 5 alpha-reductase by specific aliphatic unsaturated fatty acids.Androgenetic alopecia and microinflammation.Male pattern hair loss: prevention rather than regrowth.Dominant-negative androgen receptor inhibition of intracrine androgen-dependent growth of castration-recurrent prostate cancer.Effects of 5-alpha reductase inhibitors on erectile function, sexual desire and ejaculation.Loss of 5α-reductase type 1 accelerates the development of hepatic steatosis but protects against hepatocellular carcinoma in male mice.Effect of turosteride, a 5 alpha-reductase inhibitor, on the Dunning R3327 rat prostatic carcinoma.Pharmacological and molecular evidence for the expression of the two steroid 5 alpha-reductase isozymes in normal and hyperplastic human prostatic cells in culture.Human type 3 5α-reductase is expressed in peripheral tissues at higher levels than types 1 and 2 and its activity is potently inhibited by finasteride and dutasteride.A new look at the 5alpha-reductase inhibitor finasteride.Molecular Basis of Steroid Action in the Prostate.Identification of androgen receptor protein and 5alpha-reductase mRNA in human ocular tissues.Localization of brain 5α-reductase messenger RNA in mice selectively bred for high chronic alcohol withdrawal severity.Endocrine and adrenergic pharmacological intervention in diseases of the prostate Herbal Extracts Induce Dermal Papilla Cell Proliferation of Human Hair Follicles.Androgenic/estrogenic balance in the male rat cerebral circulation: metabolic enzymes and sex steroid receptors Clinical profile of 93 cases of 46, XY disorders of sexual development in a referral center.5α-Reductase Isozymes in the Prostate Cloning by synteny: identifying C. briggsae homologues of C. elegans genes.Estrogen and progesterone metabolism in the cervix during pregnancy and parturition Determination of the potency of a novel saw palmetto supercritical CO2 extract (SPSE) for 5α-reductase isoform II inhibition using a cell-free in vitro test system.Identification and selective inhibition of an isozyme of steroid 5 alpha-reductase in human scalp.

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Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases

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1990 nî lūn-bûn

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Proceedings of the National Academy of Sciences of the United States of America

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Structural and biochemical pro ...... rat steroid 5 alpha-reductases

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D W Russell

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Biological Actions of Androgens

A simple method for displaying the hydropathic character of a protein

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia

Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme

Characterization and expression of a cDNA encoding the human androgen receptor

Expression cloning and regulation of steroid 5 alpha-reductase, an enzyme essential for male sexual differentiation

Localization of the reduced nicotinamide adenine dinucleotide phosphate: 4 -3-ketosteroid 5 -oxidoreductase in the nuclear membrane of the rat ventral prostate.

Inhibitors of steroid 5 alpha-reductase in benign prostatic hyperplasia, male pattern baldness and acne.

Steroid 5alpha-reductase in cultured human fibroblasts. Biochemical and genetic evidence for two distinct enzyme activities.

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