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Smurf2 up-regulation activates telomere-dependent senescence

Smurf2 up-regulation activates telomere-dependent senescence

http://www.wikidata.org/entity/Q24558758

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Smurf2 participates in human trophoblast cell invasion by inhibiting TGF-beta type I receptor Overexpression of SnoN/SkiL, amplified at the 3q26.2 locus, in ovarian cancers: a role in ovarian pathogenesis Telomeres in aging and disease: lessons from zebrafish Redox control of senescence and age-related disease Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescence The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell Proliferation Smurf2 regulates hematopoietic stem cell self-renewal and aging.The WW-HECT protein Smurf2 interacts with the Docking Protein NEDD9/HEF1 for Aurora A activation.A sulfated nanofibrous mesh supporting the osteogenic differentiation of periosteum-derived cells.Characterization of novel markers of senescence and their prognostic potential in cancer.Transforming growth factor-β and the hallmarks of cancer.Ubiquitin-dependent regulation of TGFbeta signaling in cancer Gene expression changes in aging zebrafish (Danio rerio) brains are sexually dimorphic.WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) delays cellular senescence by promoting p27(Kip1) degradation in human diploid fibroblasts.Smurf2-mediated ubiquitination and degradation of Id1 regulates p16 expression during senescence.A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20.Upregulation of SIRT1 by 17β-estradiol depends on ubiquitin-proteasome degradation of PPAR-γ mediated by NEDD4-1.Effect of SMURF2 targeting on susceptibility to MEK inhibitors in melanoma.The potential effect of fibroblast senescence on wound healing and the chronic wound environment.Smurf2 regulates the senescence response and suppresses tumorigenesis in mice.The ubiquitin ligase Smurf2 suppresses TGFβ-induced epithelial-mesenchymal transition in a sumoylation-regulated manner.Notch3 functions as a tumor suppressor by controlling cellular senescence Smad ubiquitination regulatory factor 2 promotes metastasis of breast cancer cells by enhancing migration and invasiveness.Smurf2 suppresses B-cell proliferation and lymphomagenesis by mediating ubiquitination and degradation of YY1.Smad ubiquitination regulatory factor-2 in the fibrotic kidney: regulation, target specificity, and functional implication.Critical pathways in cellular senescence and immortalization revealed by gene expression profiling.Regulating the stability of TGFbeta receptors and Smads.Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1.Impaired osteogenesis of T1DM bone marrow-derived stromal cells and periosteum-derived cells and their differential in-vitro responses to growth factor rescue.Cellular senescence as a target in cancer control.Two Degradation Pathways of the p35 Cdk5 (Cyclin-dependent Kinase) Activation Subunit, Dependent and Independent of Ubiquitination Transforming growth factor beta suppresses human telomerase reverse transcriptase (hTERT) by Smad3 interactions with c-Myc and the hTERT gene.Effects of cyclic strain and growth factors on vascular smooth muscle cell responses.Expression of Smad ubiquitin regulatory factor 2 (Smurf2) in rhesus monkey endometrium and placenta during early pregnancy.DNA Damage/Telomere Stress Induced Senescence Regulation of CNKSR2 protein stability by the HECT E3 ubiquitin ligase Smurf2, and its role in breast cancer progression.

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P2860

Smurf2 up-regulation activates telomere-dependent senescence

http://www.wikidata.org/entity/Q24558758

description

2004 nî lūn-bûn

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2004 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

@zh-hk

2004年論文

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2004年論文

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2004年论文

@wuu

name

Smurf2 up-regulation activates telomere-dependent senescence

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Smurf2 up-regulation activates telomere-dependent senescence

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Smurf2 up-regulation activates telomere-dependent senescence

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type

label

Smurf2 up-regulation activates telomere-dependent senescence

@ast

Smurf2 up-regulation activates telomere-dependent senescence

@en

Smurf2 up-regulation activates telomere-dependent senescence

@nl

prefLabel

Smurf2 up-regulation activates telomere-dependent senescence

@ast

Smurf2 up-regulation activates telomere-dependent senescence

@en

Smurf2 up-regulation activates telomere-dependent senescence

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Genes & Development

P1476

Smurf2 up-regulation activates telomere-dependent senescence

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P2093

Hong Zhang

http://www.w3.org/2001/XMLSchema#string

Stanley N Cohen

http://www.w3.org/2001/XMLSchema#string

P2860

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Extension of life-span by introduction of telomerase into normal human cells

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

Specific association of human telomerase activity with immortal cells and cancer

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3028-40

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scholarly article

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4688834

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10.1101/GAD.1253004

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24

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18

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