Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis
about
Identification of protein-tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast cancer cell linesThe interaction of Src and RACK1 is enhanced by activation of protein kinase C and tyrosine phosphorylation of RACK1RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cellsRibosomal protein genes are overexpressed in colorectal cancer: isolation of a cDNA clone encoding the human S3 ribosomal proteinA new method for isolating tyrosine kinase substrates used to identify fish, an SH3 and PX domain-containing protein, and Src substrate.The role of Src in solid tumorsIncrease in activity and level of pp60c-src in progressive stages of human colorectal cancerSrc kinase becomes preferentially associated with the VEGFR, KDR/Flk-1, following VEGF stimulation of vascular endothelial cells.The molecular rationale of Src inhibition in colorectal carcinomasDasatinib sensitizes KRAS mutant colorectal tumors to cetuximabFas Versatile Signaling and Beyond: Pivotal Role of Tyrosine Phosphorylation in Context-Dependent Signaling and DiseasesThe hunting of the SrcTransforming growth factor-alpha prevents detachment-induced inhibition of c-Src kinase activity, Bcl-XL down-regulation, and apoptosis of intestinal epithelial cellsCharacterization of a novel negative regulator (DOC-2/DAB2) of c-Src in normal prostatic epithelium and cancerSrc tyrosine kinase phosphorylation of nuclear receptor HNF4α correlates with isoform-specific loss of HNF4α in human colon cancer.The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases.The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity.Bacterial expression of an active tyrosine kinase from a protein A/truncated c-src fusion protein.Src family kinase/abl inhibitor dasatinib suppresses proliferation and enhances differentiation of osteoblasts.Activation of Src kinase in primary colorectal carcinoma: an indicator of poor clinical prognosis.Elevated c-Src tyrosine kinase activity in premalignant epithelia of ulcerative colitis.Srcasm modulates EGF and Src-kinase signaling in keratinocytes.c-Src protein expression is increased in human breast cancer. An immunohistochemical and biochemical analysis.Phase II study of saracatinib (AZD0530) in patients with previously treated metastatic colorectal cancer.Phosphorylation of the SRC epithelial substrate Trask is tightly regulated in normal epithelia but widespread in many human epithelial cancers.Increases in c-Src expression level and activity do not promote the growth of human colorectal carcinoma cells in vitro and in vivo.The tyrosine phosphatase PTPRO sensitizes colon cancer cells to anti-EGFR therapy through activation of SRC-mediated EGFR signalingSrc regulates the activity of the ING1 tumor suppressor.Data-driven modeling of SRC control on the mitochondrial pathway of apoptosis: implication for anticancer therapy optimization.Slit2/Robo1 signaling promotes intestinal tumorigenesis through Src-mediated activation of the Wnt/β-catenin pathway.Genetic variability in EGFR, Src and HER2 and risk of colorectal adenoma and cancer.Differential pp60c-src activity in well and poorly differentiated human colon carcinomas and cell lines.Increases in c-Yes expression level and activity promote motility but not proliferation of human colorectal carcinoma cellsHigh sensitivity isoelectric focusing to establish a signaling biomarker for the diagnosis of human colorectal cancer.Syndecan-1 alterations during the tumorigenic progression of human colonic Caco-2 cells induced by human Ha-ras or polyoma middle T oncogenes.NMT1 (N-myristoyltransferase 1).Metabolic phenotypes and colorectal neoplasia.Elevated c-Src is linked to altered cell-matrix adhesion rather than proliferation in KM12C human colorectal cancer cells.The Src signaling pathway: a potential target in melanoma and other malignancies.Transcriptional regulation of the transforming growth factor beta 1 promoter by v-src gene products is mediated through the AP-1 complex
P2860
Q24290329-80DE2F72-627F-4695-99BD-1234D5E63F7EQ24291061-D0B9BC15-320F-447F-9A82-36D48BF7FB68Q24315691-C52B9920-4165-42FD-9AED-677C4D0A9054Q24320003-7D8F65CD-6005-49C6-8788-6D5257744856Q24533279-96F96316-778C-4246-A447-34E9C6B06319Q24616659-E583C0C4-8608-4BDE-A336-07F04C730C77Q24618378-4B3A295B-0032-4EC0-A6C2-4FF8F5142640Q24796859-6EB04CEB-E90B-4B19-A41B-8186D9E04923Q26853018-3D807879-087F-4601-98DA-9EC324413136Q27851586-63233BDA-636A-40A0-807A-A2108F830364Q28073778-501EE6A1-5AAA-4E15-A7E1-AA155F3994AAQ28199081-4EEDDFD0-5CE1-45A1-AB49-2F0C87A39817Q28580989-EAC536DF-C02E-4D12-AE44-E74CD0E9DDECQ28581678-078451A2-F437-4C45-B54E-9D94B7EA7FE3Q30010169-4BBA11A4-4767-403F-83FF-E4242DF5FF43Q30167844-BB7989C1-7D44-4BA3-9D80-8152A338C5A5Q30167852-6A7791A1-1D65-4E43-8DDB-EDE84F7DEC92Q30194912-078A7876-9BEF-4628-987F-0F0EBAA01C95Q34067118-37F33F1B-D2A8-4B9D-9831-4A89A3B916C8Q34119101-77510BD3-13F9-4EDC-A1F4-700E83B1A57FQ34124381-75EFE981-FC15-4C3E-8245-6EBFF70ED460Q34373519-0FE0C674-E28D-475E-BE13-CF68B5F664DCQ34414942-BEA13F6F-794A-437D-8064-8194A5640BA7Q34480200-A9097579-01BC-4B14-A6FD-9E8F5D85EEA3Q34502396-C234572F-CEA9-47E0-8E8F-8507A1523067Q34585402-19054EA7-78DB-4F49-A199-A4A3B12D31CAQ34654408-8B1B41D2-E88C-420D-986B-5EBFF3CA5DCEQ34667873-952F3A73-ED71-449E-993D-2291A55FB5C2Q34671696-7BF56C52-08C4-458B-8025-2DA110398FD2Q35550188-7BB0989F-4D32-4FAB-A221-700AA76607DEQ35627924-1FA43E96-601D-45F8-A26F-96E6DC75679DQ35821542-E92CBC42-1E90-490F-BCC8-EC336084189FQ36012565-9CE5774B-BF8C-4A95-92F4-FA89D15ABD67Q36113663-84A4454C-9551-44FC-AD7E-44298145E084Q36135770-83DA73B0-71F4-4C06-8153-11D8A8D8DFD9Q36227163-E5E15B7E-B577-4823-B216-2CCE2C53394BQ36418621-DFF87B51-0961-45BB-AB83-F0B29307DCC6Q36646222-605FFB7B-4E46-49FF-AFE9-2BCF455ABC28Q36675509-81EC9A3E-07E0-4D0B-B332-602FBE4EE13FQ36725987-80FB195C-7DD2-4417-9775-C497ED4C4840
P2860
Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis
description
1990 nî lūn-bûn
@nan
1990 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
name
Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis
@ast
Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis
@en
Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis
@nl
type
label
Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis
@ast
Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis
@en
Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis
@nl
prefLabel
Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis
@ast
Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis
@en
Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis
@nl
P2093
P2860
P3181
P356
P1476
Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis
@en
P2093
A I Meisler
C A Cartwright
P2860
P304
P3181
P356
10.1073/PNAS.87.2.558
P407
P577
1990-01-01T00:00:00Z