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Building zinc fingers by selection: toward a therapeutic application

Building zinc fingers by selection: toward a therapeutic application

http://www.wikidata.org/entity/Q24562828

about

Repression of the HIV-1 5' LTR promoter and inhibition of HIV-1 replication by using engineered zinc-finger transcription factors Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain Targeting serous epithelial ovarian cancer with designer zinc finger transcription factors A rapid, generally applicable method to engineer zinc fingers illustrated by targeting the HIV-1 promoter Positive and negative regulation of endogenous genes by designed transcription factors Toward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5'-GNN-3' DNA target sequences Design of polydactyl zinc-finger proteins for unique addressing within complex genomes Discovery of active proteins directly from combinatorial randomized protein libraries without display, purification or sequencing: identification of novel zinc finger proteins Chemically synthesized zinc finger molecules as nano-addressable probes for double-stranded DNAs Genome Engineering with TALE and CRISPR Systems in Neuroscience Genome-editing Technologies for Gene and Cell Therapy Protein design: toward functional metalloenzymes The Saccharomyces cerevisiae kinetochore contains a cyclin-CDK complexing homologue, as identified by in vitro reconstitution Development of zinc finger domains for recognition of the 5'-ANN-3' family of DNA sequences and their use in the construction of artificial transcription factors Engineering polydactyl zinc-finger transcription factors Development of zinc finger domains for recognition of the 5'-CNN-3' family DNA sequences and their use in the construction of artificial transcription factors Phage-displayed peptide libraries.Specific RNA binding by a single C2H2 zinc finger.DNA-protein interactions: methods for detection and analysis.Targeted methylation of the epithelial cell adhesion molecule (EpCAM) promoter to silence its expression in ovarian cancer cells Phenotypic alteration of eukaryotic cells using randomized libraries of artificial transcription factors.OTK18, a zinc-finger protein, regulates human immunodeficiency virus type 1 long terminal repeat through two distinct regulatory regions Optimizing the affinity and specificity of proteins with molecular display.Requirements for double-strand cleavage by chimeric restriction enzymes with zinc finger DNA-recognition domains Stimulation of homologous recombination through targeted cleavage by chimeric nucleases.ZiFiT (Zinc Finger Targeter): an updated zinc finger engineering tool.Synthetic zinc finger proteins: the advent of targeted gene regulation and genome modification technologies.Improved DNA binding specificity from polyzinc finger peptides by using strings of two-finger units Structure-based HIV-1 integrase inhibitor design: a future perspective.Heritable endogenous gene regulation in plants with designed polydactyl zinc finger transcription factors.Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor.An efficient and cost-effective protocol for selecting transcription factor binding sites that reduces isotope usage.Human autoantibody recognition of DNA Transcriptional regulation of the MHC class I HLA-A11 promoter by the zinc finger protein ZFX.Gene- and protein-delivered zinc finger-staphylococcal nuclease hybrid for inhibition of DNA replication of human papillomavirus.Assessment of major and minor groove DNA interactions by the zinc fingers of Xenopus transcription factor IIIA Inhibition of herpes simplex virus 1 gene expression by designer zinc-finger transcription factors Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunities.Evolution of iron(II)-finger peptides by using a bipyridyl amino acid.Xenopus transcription factor IIIA and the 5S nucleosome: development of a useful in vitro system.

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P2860

Building zinc fingers by selection: toward a therapeutic application

http://www.wikidata.org/entity/Q24562828

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1995 nî lūn-bûn

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1995 թուականի Յունուարին հրատարակուած գիտական յօդուած

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1995 թվականի հունվարին հրատարակված գիտական հոդված

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1995年の論文

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1995年論文

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1995年論文

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1995年論文

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1995年論文

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1995年論文

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1995年论文

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Building zinc fingers by selection: toward a therapeutic application

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Building zinc fingers by selection: toward a therapeutic application

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Building zinc fingers by selection: toward a therapeutic application

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Building zinc fingers by selection: toward a therapeutic application

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Building zinc fingers by selection: toward a therapeutic application

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Building zinc fingers by selection: toward a therapeutic application

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Building zinc fingers by selection: toward a therapeutic application

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Proceedings of the National Academy of Sciences of the United States of America

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Building zinc fingers by selection: toward a therapeutic application

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C F Barbas

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H Wu

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W P Yang

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P2860

Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers

Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes

Semisynthetic combinatorial antibody libraries: a chemical solution to the diversity problem

Assembly of combinatorial antibody libraries on phage surfaces: the gene III site

Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method

Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 A

High-resolution three-dimensional structure of a single zinc finger from a human enhancer binding protein in solution

Three-dimensional solution structure of a single zinc finger DNA-binding domain

The crystal structure of a two zinc-finger peptide reveals an extension to the rules for zinc-finger/DNA recognition

Use of T7 RNA polymerase to direct expression of cloned genes

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