Biochemical and pharmacological profile of a potent and selective nonpeptide antagonist of the neurotensin receptor
about
The 100-kDa neurotensin receptor is gp95/sortilin, a non-G-protein-coupled receptorNeurotensin receptor antagonist administered during cocaine withdrawal decreases locomotor sensitization and conditioned place preferenceCurcumin inhibits neurotensin-mediated interleukin-8 production and migration of HCT116 human colon cancer cellsStructure of the agonist-bound neurotensin receptorIntermolecular interactions between the neurotensin and the third extracellular loop of human neurotensin 1 receptorDirected evolution of a G protein-coupled receptor for expression, stability, and binding selectivityThe identification of nonpeptide neurotensin receptor partial agonists from the potent antagonist SR48692 using a calcium mobilization assayA paradoxical regulation of the dopamine D3 receptor expression suggests the involvement of an anterograde factor from dopamine neuronsSpinal NTS1 receptors regulate nociceptive signaling in a rat formalin tonic pain modelConstitutive activation of the neurotensin receptor 1 by mutation of Phe(358) in Helix sevenPharmacology and functional properties of NTS2 neurotensin receptors in cerebellar granule cellsCharacterization of neurotensin receptorsNeurotensin inhibition of GABAergic transmission via mGluR-induced endocannabinoid signalling in rat periaqueductal greyRepeated effects of the neurotensin receptor agonist PD149163 in three animal tests of antipsychotic activity: assessing for tolerance and cross-tolerance to clozapine.Neurotensin stimulates mitogenesis of prostate cancer cells through a novel c-Src/Stat5b pathway.Hyperactivity of the dopaminergic system in NTS1 and NTS2 null mice.Isolation and characterization of a novel conus peptide with apparent antinociceptive activity.G protein-coupled receptor signaling in human ductal pancreatic cancer cells: neurotensin responsiveness and mitogenic stimulation.Selection and characterization of DARPins specific for the neurotensin receptor 1Suicide HSVtk gene delivery by neurotensin-polyplex nanoparticles via the bloodstream and GCV Treatment specifically inhibit the growth of human MDA-MB-231 triple negative breast cancer tumors xenografted in athymic mice.Maternal separation enhances conditioned fear and decreases the mRNA levels of the neurotensin receptor 1 gene with hypermethylation of this gene in the rat amygdalaNeurotensin is a proinflammatory neuropeptide in colonic inflammationBlockade of neurotensin receptors suppresses the dopamine D1/D2 synergism on immediate early gene expression in the rat brain.Radical arylation of tyrosine and its application in the synthesis of a highly selective neurotensin receptor 2 ligand.The discovery of indole full agonists of the neurotensin receptor 1 (NTSR1).Neurotensin induces mating in Saccharomyces cerevisiae cells that express human neurotensin receptor type 1 in place of the endogenous pheromone receptor.Neurotensin regulates DARPP-32 thr34 phosphorylation in neostriatal neurons by activation of dopamine D1-type receptors.Identification of N-[(5-{[(4-methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-l-leucine (NTRC-824), a neurotensin-like nonpeptide compound selective for the neurotensin receptor type 2Morphological evidence for a neurotensinergic periaqueductal gray-rostral ventromedial medulla-spinal dorsal horn descending pathway in rat.Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditionsDiscovery of ML314, a Brain Penetrant Non-Peptidic β-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor.Use of nonpeptide antagonists to explore the physiological roles of neurotensin. Focus on brain neurotensin/dopamine interactions.Identification of 1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylic acid as a selective nonpeptide neurotensin receptor type 2 compoundNeurotensin (NTS) and its receptor (NTSR1) causes EGFR, HER2 and HER3 over-expression and their autocrine/paracrine activation in lung tumors, confirming responsiveness to erlotinib.Corticotropin-releasing hormone induces skin vascular permeability through a neurotensin-dependent process.To ingest or rest? Specialized roles of lateral hypothalamic area neurons in coordinating energy balance.Neurotensin, a novel target of Wnt/β-catenin pathway, promotes growth of neuroendocrine tumor cells.Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2In vitro functional evidence of different neurotensin-receptors modulating the motor response of human colonic muscle strips.Characterization of high affinity neurotensin receptor NTR1 in HL-60 cells and its down regulation during granulocytic differentiation.
P2860
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P2860
Biochemical and pharmacological profile of a potent and selective nonpeptide antagonist of the neurotensin receptor
description
1993 nî lūn-bûn
@nan
1993 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Biochemical and pharmacologica ...... st of the neurotensin receptor
@ast
Biochemical and pharmacologica ...... st of the neurotensin receptor
@en
Biochemical and pharmacologica ...... st of the neurotensin receptor
@nl
type
label
Biochemical and pharmacologica ...... st of the neurotensin receptor
@ast
Biochemical and pharmacologica ...... st of the neurotensin receptor
@en
Biochemical and pharmacologica ...... st of the neurotensin receptor
@nl
prefLabel
Biochemical and pharmacologica ...... st of the neurotensin receptor
@ast
Biochemical and pharmacologica ...... st of the neurotensin receptor
@en
Biochemical and pharmacologica ...... st of the neurotensin receptor
@nl
P2093
P2860
P356
P1476
Biochemical and pharmacologica ...... st of the neurotensin receptor
@en
P2093
F Jeanjean
J C Molimard
M Poncelet
R Boigegrain
P2860
P356
10.1073/PNAS.90.1.65
P407
P577
1993-01-01T00:00:00Z