BMP4 is essential for lens induction in the mouse embryo
about
Haploinsufficient Bmp4 ocular phenotypes include anterior segment dysgenesis with elevated intraocular pressureA forkhead gene, FoxE3, is essential for lens epithelial proliferation and closure of the lens vesicleSMOC1 is essential for ocular and limb development in humans and miceAutosomal dominant stapes ankylosis with broad thumbs and toes, hyperopia, and skeletal anomalies is caused by heterozygous nonsense and frameshift mutations in NOG, the gene encoding noggin.Eye morphogenesis and patterning of the optic vesiclePax6 and SOX2 form a co-DNA-binding partner complex that regulates initiation of lens developmentSox2 and Pou2f1 interact to control lens and olfactory placode developmentSerological identification of embryonic neural proteins as highly immunogenic tumor antigens in small cell lung cancerLhx2 is required for patterning and expansion of a distinct progenitor cell population committed to eye developmentLoss of the BMP antagonist, SMOC-1, causes Ophthalmo-acromelic (Waardenburg Anophthalmia) syndrome in humans and miceEye development and retinogenesisWhich FGF ligands are involved in lens induction?Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiationA trans-acting protein effect causes severe eye malformation in the Mp mouseIdentification and characterization of FGF2-dependent mRNA: microRNA networks during lens fiber cell differentiationBone morphogenetic protein 4 mediates apoptosis of capillary endothelial cells during rat pupillary membrane regressionSix3 promotes the formation of ectopic optic vesicle-like structures in mouse embryosSix3 activation of Pax6 expression is essential for mammalian lens induction and specificationForkhead Foxe3 maps to the dysgenetic lens locus and is critical in lens development and differentiationPax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eyeEndothelin-A receptor-dependent and -independent signaling pathways in establishing mandibular identityGLIS3, a novel member of the GLIS subfamily of Krüppel-like zinc finger proteins with repressor and activation functionsNotch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eyeTyrosine phosphorylation sites on FRS2alpha responsible for Shp2 recruitment are critical for induction of lens and retinaSequential activation of transcription factors in lens induction.Optic cup and facial patterning defects in ocular ectoderm beta-catenin gain-of-function mice.The level of BMP4 signaling is critical for the regulation of distinct T-box gene expression domains and growth along the dorso-ventral axis of the optic cupRybp, a polycomb complex-associated protein, is required for mouse eye development.Intracellular mediators of transforming growth factor beta superfamily signaling localize to endosomes in chicken embryo and mouse lenses in vivo.Msx1 and Msx2 function together in the regulation of primordial germ cell migration in the mouseBmp2 and Bmp4 genetically interact to support multiple aspects of mouse development including functional heart development.Essential role of BMPs in FGF-induced secondary lens fiber differentiation.Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2.Examination of SOX2 in variable ocular conditions identifies a recurrent deletion in microphthalmia and lack of mutations in other phenotypesTranscriptional regulation of bone morphogenetic protein 4 by tumor necrosis factor and its relationship with age-related macular degeneration.BMP signaling controls formation of a primordial germ cell niche within the early genital ridges.Genetic interaction between Bmp2 and Bmp4 reveals shared functions during multiple aspects of mouse organogenesis.Transdifferentiation from cornea to lens in Xenopus laevis depends on BMP signalling and involves upregulation of Wnt signallingEfficient generation of lens progenitor cells and lentoid bodies from human embryonic stem cells in chemically defined conditions.Cell models to study regulation of cell transformation in pathologies of retinal pigment epithelium
P2860
Q21283801-B59203FE-654F-4980-932B-80DCBBC014A4Q22011171-03659B38-0B7D-43E6-A1B8-1CD40EFEE8CDQ24322076-B197BEDB-CEC4-4523-A650-A64E723FF770Q24611761-333DDE3D-DA5F-44CD-B8C7-F8DDF6D43C27Q24629124-EEA6A4A2-E44F-41B2-A1E0-15749D61FD8BQ24632689-F1CF1696-7F55-43A2-9126-01627B3ADFFBQ24633891-8593435A-ABB6-4CC2-A0F3-73F4A2339449Q24681820-499487DC-65F0-45E5-962F-EEC5BF10A59AQ27324456-AB662416-668C-4874-8FDE-19840483E9E7Q27339890-830367C5-2BE6-4F48-AB5D-0246712B4B16Q28277172-0BFD5F07-F7DB-44C5-8BA1-1CEE570A88E3Q28506639-A3E81904-ACE3-4F95-8AA9-77919EC23BA7Q28507340-320D17CA-B8DB-4862-9E1F-2555DF38EA94Q28508709-F64D15FA-6E04-4C1E-8F21-82114D68D925Q28571470-374FA446-BA96-4974-93BE-543BD4E5F1E3Q28574118-03D215EE-9138-4281-8F07-78001627E519Q28585074-FFC5A71E-BE34-4273-8EAE-F47DA23836C4Q28586814-C54CC06C-32FD-4A05-A4B8-9338899C0333Q28589407-A3F796A9-60EF-4447-84F8-B2F62473D835Q28589877-64E1CECD-E825-4FDB-8580-8AD587D380E0Q28591036-BA4586E5-BBFF-4DCD-8A39-76FFB0461658Q28591478-5948D2AF-1C4A-49E4-B549-04BB7F2184B3Q28593168-CADE27A8-34F4-40C0-99C3-D723F5D1EA48Q28593379-0991859C-2A05-4091-A741-B3814C1571F8Q30306252-322E7642-0884-4501-9DAB-10FFFAEA90EDQ33236624-502AB8CF-A62A-45D3-BEAA-C2A4F9209BE4Q33266825-FB7C6FAB-EBF2-4155-A468-21009A1F597AQ33283260-F5FBE735-2B00-4087-AA7E-402EA8FF4FF6Q33288887-0F73329F-AA5B-4A88-ADCF-5570E5CBA90FQ33610102-D7098C75-213A-445A-A1B3-BE1576A55309Q33761311-099D7DDC-4485-49EB-95EE-BADCCBEB514CQ33785831-76CD48DB-4EE8-426C-BB75-92747B127356Q33818155-A7B639B0-ACE1-4437-A276-0C60C83DF168Q33821133-522C7C4D-839F-4A47-A39A-90BAA42D79B2Q33848783-9CCC4502-5E41-4130-B378-7EAD5BF68A38Q33912406-AFB009DF-877D-4EDA-8E7C-5EE07B6A21B5Q33938401-F80E0A16-3A55-4004-8CE0-E058848D1F3CQ34012279-23AF5322-8EC8-4AC5-9CE3-25CCAD846C72Q34072251-6D765090-7B24-4768-93CC-814AC5E784EAQ34080190-958B198F-6066-489F-97F8-FDBDFFECE6A3
P2860
BMP4 is essential for lens induction in the mouse embryo
description
1998 nî lūn-bûn
@nan
1998 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
BMP4 is essential for lens induction in the mouse embryo
@ast
BMP4 is essential for lens induction in the mouse embryo
@en
BMP4 is essential for lens induction in the mouse embryo
@nl
type
label
BMP4 is essential for lens induction in the mouse embryo
@ast
BMP4 is essential for lens induction in the mouse embryo
@en
BMP4 is essential for lens induction in the mouse embryo
@nl
prefLabel
BMP4 is essential for lens induction in the mouse embryo
@ast
BMP4 is essential for lens induction in the mouse embryo
@en
BMP4 is essential for lens induction in the mouse embryo
@nl
P2860
P3181
P356
P1433
P1476
BMP4 is essential for lens induction in the mouse embryo
@en
P2093
P2860
P304
P3181
P356
10.1101/GAD.12.23.3764
P407
P577
1998-12-01T00:00:00Z