The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas
about
Human Hand1 basic helix-loop-helix (bHLH) protein: extra-embryonic expression pattern, interaction partners and identification of its transcriptional repressor domainsMutations in PTF1A cause pancreatic and cerebellar agenesisPTF1 is an organ-specific and Notch-independent basic helix-loop-helix complex containing the mammalian Suppressor of Hairless (RBP-J) or its paralogue, RBP-L.neurogenin3 is required for the development of the four endocrine cell lineages of the pancreasThe bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identityPancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas developmentPancreatic ductal cells in development, regeneration, and neoplasiaTherapeutic potential of targeting acinar cell reprogramming in pancreatic cancerTranscription factor regulation of pancreatic organogenesis, differentiation and maturationLnx2 ubiquitin ligase is essential for exocrine cell differentiation in the early zebrafish pancreasEfficient targeted gene disruption in Xenopus embryos using engineered transcription activator-like effector nucleases (TALENs)Directed pancreatic acinar differentiation of mouse embryonic stem cells via embryonic signalling molecules and exocrine transcription factorspdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasisGata6 is an important regulator of mouse pancreas developmentPtf1a directly controls expression of immunoglobulin superfamily molecules Nephrin and Neph3 in the developing central nervous systemEffects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistanceSox17 regulates organ lineage segregation of ventral foregut progenitor cellsInhibition of Mist1 homodimer formation induces pancreatic acinar-to-ductal metaplasiaHnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreasRNA profiling and chromatin immunoprecipitation-sequencing reveal that PTF1a stabilizes pancreas progenitor identity via the control of MNX1/HLXB9 and a network of other transcription factorsTranscription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complexPrdm13 mediates the balance of inhibitory and excitatory neurons in somatosensory circuitsEarly pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complexGeneration and characterization of Ptf1a antiserum and localization of Ptf1a in relation to Nkx6.1 and Pdx1 during the earliest stages of mouse pancreas development.Pancreatic cancer.Ptf1a is expressed transiently in all types of amacrine cells in the embryonic zebrafish retina.Ectopic expression of Ptf1a induces spinal defects, urogenital defects, and anorectal malformations in Danforth's short tail mice.RPL38, FOSL1, and UPP1 are predominantly expressed in the pancreatic ductal epithelium.Gene array identification of Ipf1/Pdx1-/- regulated genes in pancreatic progenitor cells.Exdpf is a key regulator of exocrine pancreas development controlled by retinoic acid and ptf1a in zebrafish.Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during developmentNovel approaches to studying the genetic basis of cerebellar developmentSodium butyrate and dexamethasone promote exocrine pancreatic gene expression in mouse embryonic stem cells.Combined informatic and expression screen identifies the novel DAF-16 target HLH-13Many faces of monogenic diabetesPancreas and gallbladder agenesis in a newborn with semilobar holoprosencephaly, a case report.Lack of TCF2/vHNF1 in mice leads to pancreas agenesisMicroRNAs of the mir-17~92 cluster regulate multiple aspects of pancreatic tumor development and progression.Suppression of Ptf1a activity induces acinar-to-endocrine conversion.
P2860
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P2860
The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas
description
1998 nî lūn-bûn
@nan
1998 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
The bHLH protein PTF1-p48 is e ...... tion of the endocrine pancreas
@ast
The bHLH protein PTF1-p48 is e ...... tion of the endocrine pancreas
@en
The bHLH protein PTF1-p48 is e ...... tion of the endocrine pancreas
@nl
type
label
The bHLH protein PTF1-p48 is e ...... tion of the endocrine pancreas
@ast
The bHLH protein PTF1-p48 is e ...... tion of the endocrine pancreas
@en
The bHLH protein PTF1-p48 is e ...... tion of the endocrine pancreas
@nl
prefLabel
The bHLH protein PTF1-p48 is e ...... tion of the endocrine pancreas
@ast
The bHLH protein PTF1-p48 is e ...... tion of the endocrine pancreas
@en
The bHLH protein PTF1-p48 is e ...... tion of the endocrine pancreas
@nl
P2093
P2860
P3181
P356
P1433
P1476
The bHLH protein PTF1-p48 is e ...... tion of the endocrine pancreas
@en
P2093
B Ledermann
N Zoerkler
O Hagenbüchle
P K Wellauer
P2860
P304
P3181
P356
10.1101/GAD.12.23.3752
P407
P577
1998-12-01T00:00:00Z