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Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

http://www.wikidata.org/entity/Q24598974

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Telomeres in Cancer Therapy Bicyclic triterpenoid Iripallidal induces apoptosis and inhibits Akt/mTOR pathway in glioma cells Mutations in ATP6N1B, encoding a new kidney vacuolar proton pump 116-kD subunit, cause recessive distal renal tubular acidosis with preserved hearing Telomeric protein Pin2/TRF1 induces mitotic entry and apoptosis in cells with short telomeres and is down-regulated in human breast tumors Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing Differential regulation of telomerase activity by six telomerase subunits The human Pif1 helicase, a potential Escherichia coli RecD homologue, inhibits telomerase activity Regulation of MBD1-mediated transcriptional repression by SUMO and PIAS proteins Functional organization of the Sm core in the crystal structure of human U1 snRNP POT1 association with TRF2 regulates telomere length Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes Increased Stability of Nucleolar PinX1 in the Presence of TERT Human telomerase and its regulation Telomeres, telomerase, and tumorigenesis--a review Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms Molecular regulation of telomerase activity in aging Biomarkers of progression of chronic obstructive pulmonary disease (COPD)Telomere shortening in human diseases Therapeutic targeting of replicative immortality p53 suppresses muscle differentiation at the myogenin step in response to genotoxic stress Solution structure of the matrix attachment region-binding domain of chicken MeCP2 Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance The U1 snRNP protein U1C recognizes the 5' splice site in the absence of base pairing.MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase Sp1 and Sp3 recruit histone deacetylase to repress transcription of human telomerase reverse transcriptase (hTERT) promoter in normal human somatic cells The human Mi-2/NuRD complex and gene regulation ORegAnno 3.0: a community-driven resource for curated regulatory annotation Telomerase inhibition targets clonogenic multiple myeloma cells through telomere length-dependent and independent mechanisms Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection Arsenic inhibition of telomerase transcription leads to genetic instability Causes of genome instability: the effect of low dose chemical exposures in modern society Human telomerase reverse transcriptase (hTERT) Q169 is essential for telomerase function in vitro and in vivo The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation The histone- and PRMT5-associated protein COPR5 is required for myogenic differentiation Telomerase inhibitor Imetelstat (GRN163L) limits the lifespan of human pancreatic cancer cells Ageing-related chromatin defects through loss of the NURD complex A highly selective telomerase inhibitor limiting human cancer cell proliferation A mutant of Tetrahymena telomerase reverse transcriptase with increased processivity.Tetrahymena telomerase is active as a monomer.

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P2860

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

http://www.wikidata.org/entity/Q24598974

description

1999 nî lūn-bûn

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1999 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

1999 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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1999年の論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年论文

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name

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

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Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

@en

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

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type

label

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

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Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

@en

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

@nl

prefLabel

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

@ast

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

@en

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

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Genes & Development

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Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

@en

P2093

L Harrington

http://www.w3.org/2001/XMLSchema#string

M O Robinson

http://www.w3.org/2001/XMLSchema#string

V Mar

http://www.w3.org/2001/XMLSchema#string

W Zhou

http://www.w3.org/2001/XMLSchema#string

X Zhang

http://www.w3.org/2001/XMLSchema#string

P2860

hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization

Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT

Extension of life-span by introduction of telomerase into normal human cells

Human telomerase contains evolutionarily conserved catalytic and structural subunits

A mutant with a defect in telomere elongation leads to senescence in yeast.

Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes.

Reconstitution of human telomerase activity in vitro

THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas

Telomere length regulation

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2388-99

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scholarly article

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1841264

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10.1101/GAD.13.18.2388

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18

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13

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12800468

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10500096

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P921

apoptotic process

P932

317024

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