SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.
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SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory driveResveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterasesSynthesis and evaluation of substituted chroman-4-one and chromone derivatives as sirtuin 2-selective inhibitorsEmerging therapeutic roles for NAD(+) metabolism in mitochondrial and age-related disordersSirtuins Link Inflammation and MetabolismEpigenetics of Aging and Alzheimer's Disease: Implications for Pharmacogenomics and Drug ResponseThe role of citicoline in cognitive impairment: pharmacological characteristics, possible advantages, and doubts for an old drug with new perspectivesDietary advanced glycation end products and their role in health and diseaseProtective effects and mechanisms of sirtuins in the nervous systemSirtuin 1 and sirtuin 3: physiological modulators of metabolismTargeting sirtuin 1 to improve metabolism: all you need is NAD(+)?SIRT1 and SIRT2: emerging targets in neurodegenerationThe role of mammalian sirtuins in the regulation of metabolism, aging, and longevityFrom sirtuin biology to human diseases: an updateThe interplay between microRNAs and histone deacetylases in neurological diseasesSirtuins in epigenetic regulationDietary Phytochemicals in Neuroimmunoaging: A New Therapeutic Possibility for Humans?Adaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous systemAcetylation of NDPK-D Regulates Its Subcellular Localization and Cell SurvivalRegulation of amyloid precursor protein processing by serotonin signalingBCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targetsSIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system.Oral glycotoxins are a modifiable cause of dementia and the metabolic syndrome in mice and humansDiscovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics ConsortiumMetabolic stress modulates Alzheimer's β-secretase gene transcription via SIRT1-PPARγ-PGC-1 in neurons.Small-molecule allosteric activators of sirtuins.Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain.Marginal Vitamin A Deficiency Exacerbates Memory Deficits Following Aβ1-42 Injection in Rats.Resveratrol and Alzheimer's disease: message in a bottle on red wine and cognition.Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi.Acetylation of tau inhibits its degradation and contributes to tauopathySirtuins: guardians of mammalian healthspan.Early-Life Exposure to Lead Induces Cognitive Impairment in Elder Mice Targeting SIRT1 Phosphorylation and Oxidative Alterations.ADAM10 missense mutations potentiate β-amyloid accumulation by impairing prodomain chaperone functionNAD+ and sirtuins in aging and disease.Overexpression of SIRT1 in mouse forebrain impairs lipid/glucose metabolism and motor function.Testosterone deficiency accelerates neuronal and vascular aging of SAMP8 mice: protective role of eNOS and SIRT1Neuroprotective and metabolic effects of resveratrol: therapeutic implications for Huntington's disease and other neurodegenerative disorders.The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD(+).SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function
P2860
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P2860
SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10
@nl
SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.
@ast
SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.
@en
type
label
SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10
@nl
SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.
@ast
SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.
@en
prefLabel
SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10
@nl
SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.
@ast
SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.
@en
P2093
P2860
P3181
P1433
P1476
SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.
@en
P2093
Dena E Cohen
Diana Wang
Gizem Donmez
Leonard Guarente
P2860
P304
P3181
P356
10.1016/J.CELL.2010.06.020
P407
P577
2010-07-01T00:00:00Z