The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors
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Cannabis Use during Adolescent Development: Susceptibility to Psychiatric IllnessBiochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12)Physiology of the orexinergic/hypocretinergic system: a revisit in 2012Why do cannabinoid receptors have more than one endogenous ligand?Marijuana, Spice 'herbal high', and early neural development: implications for rescheduling and legalizationElevating endocannabinoid levels: pharmacological strategies and potential therapeutic applicationsRegulation of nausea and vomiting by cannabinoids and the endocannabinoid systemMonoacylglycerols activate TRPV1--a link between phospholipase C and TRPV1Fever Is Mediated by Conversion of Endocannabinoid 2-Arachidonoylglycerol to Prostaglandin E2The Concise Guide to PHARMACOLOGY 2013/14: enzymes.Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents.Monoglyceride lipase deficiency affects hepatic cholesterol metabolism and lipid-dependent gut transit in ApoE-/- mice.The dual FAAH/MAGL inhibitor JZL195 has enhanced effects on endocannabinoid transmission and motor behavior in rats as compared to those of the MAGL inhibitor JZL184Lipid phosphate phosphatase inhibitors locally amplify lysophosphatidic acid LPA1 receptor signalling in rat brain cryosections without affecting global LPA degradationMetabolism of endocannabinoids and related N-acylethanolamines: canonical and alternative pathways.Intrinsic up-regulation of 2-AG favors an area specific neuronal survival in different in vitro models of neuronal damage.Endocannabinoid modulation by FAAH and monoacylglycerol lipase within the analgesic circuitry of the periaqueductal greyThe fatty acid amide hydrolase inhibitor PF-3845 promotes neuronal survival, attenuates inflammation and improves functional recovery in mice with traumatic brain injury.Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors.Evidence for bidirectional endocannabinoid transport across cell membranesMammalian alpha beta hydrolase domain (ABHD) proteins: Lipid metabolizing enzymes at the interface of cell signaling and energy metabolism.Comparative effects of parathion and chlorpyrifos on endocannabinoid and endocannabinoid-like lipid metabolites in rat striatumSelective inhibition of alpha/beta-hydrolase domain 6 attenuates neurodegeneration, alleviates blood brain barrier breakdown, and improves functional recovery in a mouse model of traumatic brain injuryα/β-Hydrolase domain-containing 6 (ABHD6) negatively regulates the surface delivery and synaptic function of AMPA receptors.The monoacylglycerol lipase inhibitor JZL184 attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of actionMembrane phospholipid bilayer as a determinant of monoacylglycerol lipase kinetic profile and conformational repertoire.Comparative effects of parathion and chlorpyrifos on extracellular endocannabinoid levels in rat hippocampus: influence on cholinergic toxicity.Transient Cannabinoid Receptor 2 Blockade during Immunization Heightens Intensity and Breadth of Antigen-specific Antibody Responses in Young and Aged mice.The Ratio of 2-AG to Its Isomer 1-AG as an Intrinsic Fine Tuning Mechanism of CB1 Receptor Activation.Anandamide and 2-arachidonoylglycerol: pharmacological properties, functional features, and emerging specificities of the two major endocannabinoids.PUFA-derived endocannabinoids: an overview.The exocytotic machinery.Interplay between synaptic endocannabinoid signaling and metaplasticity in neuronal circuit function and dysfunction.Endocannabinoids, related compounds and their metabolic routes.Signal transduction: From the atomic age to the post-genomic eraThe potential role of cannabinoids in epilepsy treatment.Role of the endocannabinoid system in vertebrates: Emphasis on the zebrafish model.Interactions between the endocannabinoid and nicotinic cholinergic systems: preclinical evidence and therapeutic perspectives.Role of the Endocannabinoid System in the Pathophysiology of Schizophrenia.2-AG promotes the expression of conditioned fear via cannabinoid receptor type 1 on GABAergic neurons.
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P2860
The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors
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2012 nî lūn-bûn
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2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած
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2012 թվականի փետրվարին հրատարակված գիտական հոդված
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年论文
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The serine hydrolases MAGL, AB ...... through cannabinoid receptors
@ast
The serine hydrolases MAGL, AB ...... through cannabinoid receptors
@en
The serine hydrolases MAGL, AB ...... through cannabinoid receptors
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label
The serine hydrolases MAGL, AB ...... through cannabinoid receptors
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The serine hydrolases MAGL, AB ...... through cannabinoid receptors
@en
The serine hydrolases MAGL, AB ...... through cannabinoid receptors
@nl
prefLabel
The serine hydrolases MAGL, AB ...... through cannabinoid receptors
@ast
The serine hydrolases MAGL, AB ...... through cannabinoid receptors
@en
The serine hydrolases MAGL, AB ...... through cannabinoid receptors
@nl
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The serine hydrolases MAGL, AB ...... through cannabinoid receptors
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S M Saario
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10.1111/J.1748-1716.2011.02280.X
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P577
2011-04-22T00:00:00Z