Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth - Wikidata - wikimedia - TriplyDB

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

http://www.wikidata.org/entity/Q24603549

about

Is there a role for carbohydrate restriction in the treatment and prevention of cancer?Clinical significance of T cell metabolic reprogramming in cancer Chinese Herbs Interfering with Cancer Reprogramming Metabolism Role of Redox Status in Development of Glioblastoma The sweet trap in tumors: aerobic glycolysis and potential targets for therapy The Warburg effect and drug resistance Ovarian clear cell carcinoma meets metabolism; HNF-1β confers survival benefits through the Warburg effect and ROS reduction Components of cancer metabolism and therapeutic interventions Integrating canonical and metabolic signalling programmes in the regulation of T cell responses Therapeutic targeting of cellular metabolism in cells with hyperactive mTORC1: a paradigm shift Pyruvate kinase M2 at a glance PFKFB3 Regulates Oxidative Stress Homeostasis via Its S-Glutathionylation in Cancer mTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer, obesity, and aging A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect PDK4 protein promotes tumorigenesis through activation of cAMP-response element-binding protein (CREB)-Ras homolog enriched in brain (RHEB)-mTORC1 signaling cascade Insulin promotes glucose consumption via regulation of miR-99a/mTOR/PKM2 pathway Brain-expressed X-linked 2 Is Pivotal for Hyperactive Mechanistic Target of Rapamycin (mTOR)-mediated Tumorigenesis Oleanolic acid suppresses aerobic glycolysis in cancer cells by switching pyruvate kinase type M isoforms MTOR inhibition attenuates DNA damage and apoptosis through autophagy-mediated suppression of CREB1 Six Hours after Infection, the Metabolic Changes Induced by WSSV Neutralize the Host's Oxidative Stress Defenses Three steps to the immortality of cancer cells: senescence, polyploidy and self-renewal.Insulin regulates glucose consumption and lactate production through reactive oxygen species and pyruvate kinase M2.Estradiol promotes pentose phosphate pathway addiction and cell survival via reactivation of Akt in mTORC1 hyperactive cells.Diffuse Cystic Lung Disease. Part I.Difference in glycerol levels between leukemia and normal bone marrow stem cells.Concordant release of glycolysis proteins into the plasma preceding a diagnosis of ER+ breast cancer.Osteopontin is Critical for Hyperactive mTOR-Induced Tumorigenesis in Oral Squamous Cell Carcinoma Downregulation of Mitochondrial Single Stranded DNA Binding Protein (SSBP1) Induces Mitochondrial Dysfunction and Increases the Radiosensitivity in Non-Small Cell Lung Cancer Cells.Increased drug resistance is associated with reduced glucose levels and an enhanced glycolysis phenotype.Screening of well-established drugs targeting cancer metabolism: reproducibility of the efficacy of a highly effective drug combination in mice.Activation of Akt protects cancer cells from growth inhibition induced by PKM2 knockdown Modulation of glucose transporter 1 (GLUT1) expression levels alters mouse mammary tumor cell growth in vitro and in vivo.PKM2: the thread linking energy metabolism reprogramming with epigenetics in cancer Pericellular pH homeostasis is a primary function of the Warburg effect: inversion of metabolic systems to control lactate steady state in tumor cells.TSC1/2 signaling complex is essential for peripheral naïve CD8+ T cell survival and homeostasis in mice.7-Ketocholesterol induces P-glycoprotein through PI3K/mTOR signaling in hepatoma cells CD39 and CD161 modulate Th17 responses in Crohn's disease.Resveratrol inhibits cancer cell metabolism by down regulating pyruvate kinase M2 via inhibition of mammalian target of rapamycin.Management of metastatic renal cell carcinoma patients with poor-risk features: current status and future perspectives.Missense mutations in pyruvate kinase M2 promote cancer metabolism, oxidative endurance, anchorage independence, and tumor growth in a dominant negative manner.

P2860

Q21245058-28EA8792-4CD5-4B98-BBA3-25321DFA6C9C Q26741974-BDF46EAE-CF2D-4267-A297-53B0D7E94551 Q26744552-F822060C-A715-4B86-96AA-FB3A38ABECA0 Q26747419-5DD9B3BA-2981-4780-881F-89EA6A4EF822 Q26766079-342FD1CC-86A6-4F5B-9473-A6BF9A0C7E7A Q26770007-ED3261A3-17DA-473C-869B-F5C1D8B0A306 Q26786610-56C57975-F58D-408F-98DC-705C872FC61A Q26823746-ED5B5E44-06AE-4F99-ADC3-A8D09D7DC02A Q26851446-466FBFD3-65D2-4DB6-A71D-84C99702CBB5 Q26999365-42869D37-C073-42DE-98EC-1FCF85EC7B67 Q27005722-6F1F4FDF-9DD1-41DD-B065-40FC1D2BD6AB Q27680730-C2836333-7FD4-4D27-A88E-91BE92AFB25B Q28081442-72EA3005-B6B5-4631-AA66-50F4064C26B8 Q28237387-5861E623-FF9E-4DBD-952F-7067EE572C9E Q28246822-D4598766-BB00-4CD8-85D8-1B09F42CDE24 Q28384176-1B55422C-3B9F-4497-92C2-B6DDA4B03D22 Q28393897-2383273F-8A44-4F39-A4B5-A23E5CD171DE Q28540878-9E159636-2CA8-408E-9BA9-9C3EA31A837A Q28576369-F13CE82C-3236-4895-A81E-9C2E918728BC Q28828311-A9065618-E4EE-4B41-ADDA-225DD1429731 Q33590178-3D922CFE-6151-4C4D-92C5-8400F5F54E44 Q33668078-BDBCD6C2-7F08-4217-9B29-24903FFD2D97 Q33720145-BF6D89E7-C153-4F27-9407-C8F2C5EC7ACE Q33722950-B8F19CB2-4B46-4A53-9868-AD150AD35D79 Q33778338-4C9F1881-4885-4607-85F8-E37C09635C1A Q33790538-C6B4A22F-A562-482D-9790-15EF4E394194 Q33820845-BDD80DA8-FA1E-497B-ADF8-5FF14701DD66 Q33820859-075E2A33-4CF6-414A-8FBD-3A10FFF52554 Q33842748-ABEC6208-A163-45EA-90F1-D9E8BD1D48D4 Q33927565-73A472DE-C222-4F03-82A2-9836D2FFD93C Q33938907-257598BA-DC8B-47E7-93B3-8ABF67D3EE4A Q33986152-434DFC2A-CD01-4A0F-94B5-C7CDD7ACC705 Q34072206-B04D25C9-5C4B-44E0-B9E7-39AD131B8794 Q34154991-AE000355-B781-43E4-B2E8-18A11930BB3B Q34170051-7225B3AF-503F-49D0-A422-1137F0C8B903 Q34185571-D690FCDB-F3DD-4C7B-9152-7032FDC6B7BA Q34218735-FBA0837D-40E5-467A-A552-AC3471634F0B Q34264934-FA3AA501-B5C4-4EA1-990B-4B63CFF04F97 Q34351372-2430C0BB-DEF3-44F0-B1B9-9FE20713F84C Q34401981-0172CB79-3595-447D-9D55-265670A82395

P2860

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

http://www.wikidata.org/entity/Q24603549

description

2011 nî lūn-bûn

@nan

2011 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի մարտին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Mammalian target of rapamycin ...... ic glycolysis and tumor growth

@ast

Mammalian target of rapamycin ...... ic glycolysis and tumor growth

@en

Mammalian target of rapamycin ...... ic glycolysis and tumor growth

@nl

type

label

Mammalian target of rapamycin ...... ic glycolysis and tumor growth

@ast

Mammalian target of rapamycin ...... ic glycolysis and tumor growth

@en

Mammalian target of rapamycin ...... ic glycolysis and tumor growth

@nl

prefLabel

Mammalian target of rapamycin ...... ic glycolysis and tumor growth

@ast

Mammalian target of rapamycin ...... ic glycolysis and tumor growth

@en

Mammalian target of rapamycin ...... ic glycolysis and tumor growth

@nl

P1433

Q24603549-5731C1D6-CEF4-4E7E-8247-A7A46B6F1C22

P1476

Q24603549-D38CD416-4A64-4DCD-BF65-5C2125909E70

P2093

Q24603549-1A6A8C82-7AF0-4C19-84AE-492FEEA6945A

Q24603549-1D388CC2-1D11-4E23-BFC7-0659068EA356

Q24603549-2C565EA2-F1AD-48BB-9CF3-3F42BBD6CB8D

Q24603549-48149F55-3269-47CC-9AD4-7E8DF1FD978D

Q24603549-4C67FE0F-626A-4DD4-A267-B8830EF0A4CB

Q24603549-4DAFC67B-7B0E-4E99-AA9E-BAC3DCAAD1E8

Q24603549-5A737C66-F012-488F-9B21-83683350AD20

Q24603549-5AC63CD6-26AA-4CB5-B811-5736FCCA9680

Q24603549-6E688A81-A9AF-414B-B1A6-E12C6F54DE5D

Q24603549-6F20CFCB-56DC-4EA6-88CC-D265939DB25D

P2860

Q24603549-087E8D25-AFC2-4F06-8C12-AB32823635CF

Q24603549-18D5AD9A-218B-408D-859B-3E9E439F2ACA

Q24603549-23300540-88F1-42EA-9E18-B6FA43DDAC08

Q24603549-26985FD2-05E7-474F-8D5A-2DAC13B6B629

Q24603549-292014C3-E425-4B56-8C90-F586D0A69877

Q24603549-307CA24C-A644-4161-84E1-19C5183FC19F

Q24603549-30AA26C6-BA4C-497A-ACA6-1EF5244729DA

Q24603549-3365BF74-8AB6-490D-B2D2-2228E38B5D1B

Q24603549-34CC5B93-DFD8-4B69-928A-1089CE0ACA93

Q24603549-3645C06C-BCE9-40A2-8F63-04DDBFC8302F

P304

Q24603549-3CAF30CD-3DEC-4BB1-B285-E8218D3941A3

P31

Q24603549-90DF0FF0-C114-4E17-ACC3-C4EFE0BB79AD

P3181

Q24603549-E7B63887-0C83-47A3-AFC0-C2B3A3C0A273

P356

Q24603549-75FA45B1-3E8B-41F9-BD1D-8262C7BC1194

P407

Q24603549-97C0C5CE-BBFC-472F-BE7C-2EB38CCDC131

P433

Q24603549-FC01DC4C-8D62-4EBF-8220-5B7EA3409E36

P478

Q24603549-04D3074B-7BA9-432E-8282-A056312F29FB

P577

Q24603549-4861DF04-F800-48F0-BBE8-28EC3E727B8B

P5875

Q24603549-380087FC-C2B4-463C-B259-70D1C99C91C3

P698

Q24603549-92174931-7B7E-4B76-8D52-94307BD74234

P932

Q24603549-2F785330-AF6F-4D71-8ED3-9A3F52EFB985

P3181

P356

PNAS.1014769108

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Mammalian target of rapamycin ...... ic glycolysis and tumor growth

@en

P2093

David Kwiatkowski

http://www.w3.org/2001/XMLSchema#string

Fang Wang

http://www.w3.org/2001/XMLSchema#string

Haiyong Peng

http://www.w3.org/2001/XMLSchema#string

Han You

http://www.w3.org/2001/XMLSchema#string

Hiroaki Onda

http://www.w3.org/2001/XMLSchema#string

Hongbing Zhang

http://www.w3.org/2001/XMLSchema#string

Hongwang Yang

http://www.w3.org/2001/XMLSchema#string

Jianhui Ma

http://www.w3.org/2001/XMLSchema#string

June Goto

http://www.w3.org/2001/XMLSchema#string

Long Chang

http://www.w3.org/2001/XMLSchema#string

P2860

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1

Understanding the Warburg effect: the metabolic requirements of cell proliferation

HIF-1: upstream and downstream of cancer metabolism

Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells

Brick by brick: metabolism and tumor cell growth

On the Origin of Cancer Cells

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

Cancer cell metabolism: Warburg and beyond

P304

4129-34

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

900103

http://www.w3.org/2001/XMLSchema#string

P356

10.1073/PNAS.1014769108

http://www.w3.org/2001/XMLSchema#string

P407

P433

10

http://www.w3.org/2001/XMLSchema#string

P478

108

http://www.w3.org/2001/XMLSchema#string

P577

2011-03-08T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

49839721

http://www.w3.org/2001/XMLSchema#string

P698

21325052

http://www.w3.org/2001/XMLSchema#string

P932

3054028

http://www.w3.org/2001/XMLSchema#string