From an old remedy to a magic bullet: molecular mechanisms underlying the therapeutic effects of arsenic in fighting leukemia - Wikidata - wikimedia - TriplyDB

From an old remedy to a magic bullet: molecular mechanisms underlying the therapeutic effects of arsenic in fighting leukemia

From an old remedy to a magic bullet: molecular mechanisms underlying the therapeutic effects of arsenic in fighting leukemia

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A drug from poison: how the therapeutic effect of arsenic trioxide on acute promyelocytic leukemia was discovered Lung tumors in mice induced by "whole-life" inorganic arsenic exposure at human-relevant doses Metalloid compounds as drugs How animal models of leukaemias have already benefited patients Application of Traditional Chinese Medical Herbs in Prevention and Treatment of Respiratory Syncytial Virus Targeting of leukemia-initiating cells in acute promyelocytic leukemia Alterations in glutathione levels and apoptotic regulators are associated with acquisition of arsenic trioxide resistance in multiple myeloma Maintenance therapy with all-trans retinoic acid and arsenic trioxide improves relapse-free survival in adults with low- to intermediate-risk acute promyelocytic leukemia who have achieved complete remission after consolidation therapy.Resveratrol, a natural antioxidant, has a protective effect on liver injury induced by inorganic arsenic exposure Evaluation of the carcinogenicity of inorganic arsenic.Autophagy interplays with apoptosis and cell cycle regulation in the growth inhibiting effect of Trisenox in HEP-2, a laryngeal squamous cancer.Developing traditional chinese medicine in the era of evidence-based medicine: current evidences and challenges.Incidence of secondary neoplasms in patients with acute promyelocytic leukemia treated with all-trans retinoic acid plus chemotherapy or with all-trans retinoic acid plus arsenic trioxide Tetraarsenictetrasulfide and Arsenic Trioxide Exert Synergistic Effects on Induction of Apoptosis and Differentiation in Acute Promyelocytic Leukemia Cells.Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells.Arsenic Primes Human Bone Marrow CD34+ Cells for Erythroid Differentiation Altered nuclear cofactor switching in retinoic-resistant variants of the PML-RARα oncoprotein of acute promyelocytic leukemia Arsenic trioxide negatively affects Echinococcus granulosus A Pediatric Acute Promyelocytic Leukemia With a Rare Karyotype of ider(17)(q10)t(15;17) and Favorable Outcome: A Case Report Arsenic sulfide combined with JQ1, chemotherapy agents, or celecoxib inhibit gastric and colon cancer cell growth.Identification of berberine as a direct thrombin inhibitor from traditional Chinese medicine through structural, functional and binding studies Dose-dependent effects of selenite (Se(4+)) on arsenite (As(3+))-induced apoptosis and differentiation in acute promyelocytic leukemia cells.Systematic identification of arsenic-binding proteins reveals that hexokinase-2 is inhibited by arsenic.Study of Arsenic Sulfide in Solid Tumor Cells Reveals Regulation of Nuclear Factors of Activated T-cells by PML and p53.Redox control of leukemia: from molecular mechanisms to therapeutic opportunities.8-CPT-cAMP/all-trans retinoic acid targets t(11;17) acute promyelocytic leukemia through enhanced cell differentiation and PLZF/RARα degradation.Evaluation of arsenic trioxide by the pediatric preclinical testing program with a focus on Ewing sarcoma.Novel function of FAXDC2 in megakaryopoiesis.How I treat children and adolescents with acute promyelocytic leukaemia.Anticancer activity of small-molecule and nanoparticulate arsenic(III) complexes.Nephroprotective effect of astaxanthin against trivalent inorganic arsenic-induced renal injury in wistar rats.Novel function of the chromosome 7 open reading frame 41 gene to promote leukemic megakaryocyte differentiation by modulating TPA-induced signaling.Retinoic acid and arsenic trioxide in the treatment of acute promyelocytic leukemia: current perspectives.Influences of Realgar-Indigo naturalis, A Traditional Chinese Medicine Formula, on the Main CYP450 Activities in Rats Using a Cocktail Method.Targeted therapy: The new lease on life for acute promyelocytic leukemia, and beyond.Differentiation therapy of acute myeloid leukemia.Synergistic targeted therapy for acute promyelocytic leukaemia: a model of translational research in human cancer.p53 as an Effector or Inhibitor of Therapy Response.Current management of newly diagnosed acute promyelocytic leukemia.The mechanism of synergistic effects of arsenic trioxide and rapamycin in acute myeloid leukemia cell lines lacking typical t(15;17) translocation.

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From an old remedy to a magic bullet: molecular mechanisms underlying the therapeutic effects of arsenic in fighting leukemia

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2011年の論文

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PML nuclear bodies

Induction of metallothionein I by arsenic via metal-activated transcription factor 1. Critical role of c-terminal cysteine residues in arsenic sensing

Critical cysteine residues of Kelch-like ECH-associated protein 1 in arsenic sensing and suppression of nuclear factor erythroid 2-related factor 2

PML/RARalpha targets promoter regions containing PU.1 consensus and RARE half sites in acute promyelocytic leukemia

In vivo and in vitro characterization of the B1 and B2 zinc-binding domains from the acute promyelocytic leukemia protooncoprotein PML

The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto-oncoprotein PML

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

A history of the use of arsenicals in man

Cancer risks from arsenic in drinking water

The tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphatase

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