SPC4/PACE4 regulates a TGFbeta signaling network during axis formation - Wikidata - wikimedia - TriplyDB

SPC4/PACE4 regulates a TGFbeta signaling network during axis formation

SPC4/PACE4 regulates a TGFbeta signaling network during axis formation

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Common variants in left/right asymmetry genes and pathways are associated with relative hand skill Proprotein convertase PACE4 is down-regulated by the basic helix-loop-helix transcription factor hASH-1 and MASH-1 Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5 PCSK6 is associated with handedness in individuals with dyslexia Loss-of-function mutations in growth differentiation factor-1 (GDF1) are associated with congenital heart defects in humans Furin at the cutting edge: from protein traffic to embryogenesis and disease The Maternal Maverick/GDF15-like TGF-β Ligand Panda Directs Dorsal-Ventral Axis Formation by Restricting Nodal Expression in the Sea Urchin Embryo Subtilisin-like proprotein convertase expression, localization, and activity in the human retina and optic nerve head PCSK6-mediated corin activation is essential for normal blood pressure In vivo evidence that furin from hepatocytes inactivates PCSK9 Blimp1/Prdm1 governs terminal differentiation of endovascular trophoblast giant cells and defines multipotent progenitors in the developing placenta Notch signaling regulates left-right asymmetry determination by inducing Nodal expression Nodal protein processing and fibroblast growth factor 4 synergize to maintain a trophoblast stem cell microenvironment The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions Estrogen-dependent gene expression in the mouse ovary.Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects.Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst.Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse Heterotaxy-spectrum heart defects in Zic3 hypomorphic mice.The genetic relationship between handedness and neurodevelopmental disorders.Mapping modifiers affecting muscularity of the myostatin mutant (Mstn(Cmpt-dl1Abc)) compact mouse PCSK6 VNTR Polymorphism Is Associated with Degree of Handedness but Not Direction of Handedness.Furin is the major processing enzyme of the cardiac-specific growth factor bone morphogenetic protein 10.The microenvironment patterns the pluripotent mouse epiblast through paracrine Furin and Pace4 proteolytic activities.Development of Lung Epithelium from Induced Pluripotent Stem Cells.PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation.Loss of endothelial furin leads to cardiac malformation and early postnatal death.In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate.Gene network and familial analyses uncover a gene network involving Tbx5/Osr1/Pcsk6 interaction in the second heart field for atrial septation.A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype Anteriorward shifting of asymmetric Xnr1 expression and contralateral communication in left-right specification in Xenopus.BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4.An activin/furin regulatory loop modulates the processing and secretion of inhibin alpha- and betaB-subunit dimers in pituitary gonadotrope cells.PIERCE1 is critical for specification of left-right asymmetry in mice.MicroRNA-127 Promotes Mesendoderm Differentiation of Mouse Embryonic Stem Cells by Targeting Left-Right Determination Factor 2 Genetics of the first seven proprotein convertase enzymes in health and disease.Proprotein convertase subtilisin/kexin type 7 (PCSK7) is essential for the zebrafish development and bioavailability of transforming growth factor β1a (TGFβ1a).Site-specific cleavage of BMP4 by furin, PC6, and PC7.Ultrastructural and immunocharacterization of undifferentiated myocardial cells in the developing mouse heart.

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P2860

SPC4/PACE4 regulates a TGFbeta signaling network during axis formation

http://www.wikidata.org/entity/Q24606300

description

2000 nî lūn-bûn

@nan

2000 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2000年の論文

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2000年論文

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2000年論文

@zh-hant

2000年論文

@zh-hk

2000年論文

@zh-mo

2000年論文

@zh-tw

2000年论文

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name

SPC4/PACE4 regulates a TGFbeta signaling network during axis formation

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SPC4/PACE4 regulates a TGFbeta signaling network during axis formation

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SPC4/PACE4 regulates a TGFbeta signaling network during axis formation

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type

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SPC4/PACE4 regulates a TGFbeta signaling network during axis formation

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SPC4/PACE4 regulates a TGFbeta signaling network during axis formation

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SPC4/PACE4 regulates a TGFbeta signaling network during axis formation

@nl

prefLabel

SPC4/PACE4 regulates a TGFbeta signaling network during axis formation

@ast

SPC4/PACE4 regulates a TGFbeta signaling network during axis formation

@en

SPC4/PACE4 regulates a TGFbeta signaling network during axis formation

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Genes & Development

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SPC4/PACE4 regulates a TGFbeta signaling network during axis formation

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P2093

D B Constam

http://www.w3.org/2001/XMLSchema#string

E J Robertson

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P2860

Inactivation of proprotein convertase, PACE4, by alpha1-antitrypsin Portland (alpha1-PDX), a blocker of proteolytic activation of bone morphogenetic protein during embryogenesis: evidence that PACE4 is able to form an SDS-stable acyl intermediate wi

A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse

Left-right asymmetric expression of the TGF beta-family member lefty in mouse embryos

lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal

Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signaling pathway in determination of left-right asymmetry

The transcription factor Pitx2 mediates situs-specific morphogenesis in response to left-right asymmetric signals

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse

Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup

Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis

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1146-55

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721988

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9

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14

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10809672

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316583

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