Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles
about
Active site profiling reveals coupling between domains in SRC-family kinasesStructural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic MacrocyclesConstitutive Activity in an Ancestral Form of Abl Tyrosine Kinase.Identification of potent Yes1 kinase inhibitors using a library screening approach.Discovery of small-molecule interleukin-2 inhibitors from a DNA-encoded chemical library.Expanding the scope of PNA-encoded synthesis (PES): Mtt-protected PNA fully orthogonal to fmoc chemistry and a broad array of robust diversity-generating reactions.Small molecule substrate phosphorylation site inhibitors of protein kinases: approaches and challenges.Automated screening for small organic ligands using DNA-encoded chemical libraries.Development of a highly selective c-Src kinase inhibitor.Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules.Identification of potential inhibitors based on compound proposal contest: Tyrosine-protein kinase Yes as a target.Selective targeting of distinct active site nucleophiles by irreversible SRC-family kinase inhibitors.Conformational transition paths harbor structures useful for aiding drug discovery and understanding enzymatic mechanisms in protein kinases.The Evolution of DNA-Templated Synthesis as a Tool for Materials Discovery.Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites.Reducing product inhibition in nucleic acid-templated ligation reactions: DNA-templated cycligation.Cytotoxic peptide–PNA conjugates obtained by RNA-programmed peptidyl transfer with turnoverBioorthogonal reactions challenged: DNA templated native chemical ligation during PCR
P2860
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P2860
Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles
description
2012 nî lūn-bûn
@nan
2012 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles
@ast
Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles
@en
Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles
@nl
type
label
Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles
@ast
Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles
@en
Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles
@nl
prefLabel
Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles
@ast
Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles
@en
Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles
@nl
P2093
P2860
P356
P1476
Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles
@en
P2093
David R Liu
Michael Pulkoski-Gross
Ralph E Kleiner
P2860
P2888
P304
P356
10.1038/NCHEMBIO.792
P407
P577
2012-02-19T00:00:00Z
P6179
1004324348