Isolation of phosphatidylethanolamine as a solitary cofactor for prion formation in the absence of nucleic acids
about
Cofactor molecules maintain infectious conformation and restrict strain properties in purified prionsInsights into Mechanisms of Chronic NeurodegenerationYeast prions: structure, biology, and prion-handling systemsSynthetic prions with novel strain-specified propertiesIntraperitoneal Infection of Wild-Type Mice with Synthetically Generated Mammalian PrionEfficient uptake and dissemination of scrapie prion protein by astrocytes and fibroblasts from adult hamster brainSialylation of prion protein controls the rate of prion amplification, the cross-species barrier, the ratio of PrPSc glycoform and prion infectivityEvidence that bank vole PrP is a universal acceptor for prionsReversible off and on switching of prion infectivity via removing and reinstalling prion sialylation.The effect of β2-α2 loop mutation on amyloidogenic properties of the prion proteinCritical significance of the region between Helix 1 and 2 for efficient dominant-negative inhibition by conversion-incompetent prion proteinRecombinant prion protein refolded with lipid and RNA has the biochemical hallmarks of a prion but lacks in vivo infectivityAnti-prion activity of a panel of aromatic chemical compounds: in vitro and in silico approachesShaking alone induces de novo conversion of recombinant prion proteins to β-sheet rich oligomers and fibrilsRole of polysaccharide and lipid in lipopolysaccharide induced prion protein conversionPhysical, chemical and kinetic factors affecting prion infectivityCharge neutralization of the central lysine cluster in prion protein (PrP) promotes PrP(Sc)-like folding of recombinant PrP amyloids.Prion Protein Prolines 102 and 105 and the Surrounding Lysine Cluster Impede Amyloid Formation.Lipid-dependent generation of dual topology for a membrane protein.The structure of the infectious prion protein: experimental data and molecular models.Heparin binding confers prion stability and impairs its aggregation.Gene expression profiling of brains from bovine spongiform encephalopathy (BSE)-infected cynomolgus macaques.Synthesis of high titer infectious prions with cofactor molecules.Comparison of 2 synthetically generated recombinant prions.Lipopolysaccharide induced conversion of recombinant prion protein.The importance of prions.A C-terminal membrane anchor affects the interactions of prion proteins with lipid membranes.Nucleic acid induced unfolding of recombinant prion protein globular fragment is pH dependent.Insect cell-derived cofactors become fully functional after proteinase K and heat treatment for high-fidelity amplification of glycosylphosphatidylinositol-anchored recombinant scrapie and BSE prion proteins.Transgenic fatal familial insomnia mice indicate prion infectivity-independent mechanisms of pathogenesis and phenotypic expression of disease.Contrasting Effects of Two Lipid Cofactors of Prion Replication on the Conformation of the Prion ProteinA Structural and Functional Comparison Between Infectious and Non-Infectious Autocatalytic Recombinant PrP Conformers.Requirements for mutant and wild-type prion protein misfolding in vitro.Antiprion Activity of DB772 and Related Monothiophene- and Furan-Based Analogs in a Persistently Infected Ovine Microglia Culture SystemEarly Generation of New PrPSc on Blood Vessels after Brain Microinjection of Scrapie in MiceStabilization of a prion strain of synthetic origin requires multiple serial passagesAnti-Prion Screening for Acridine, Dextran, and Tannic Acid using Real Time-Quaking Induced Conversion: A Comparison with PrPSc-Infected Cell ScreeningTwo alternative pathways for generating transmissible prion disease de novo.Secondary-structure prediction revisited: Theoretical β-sheet propensity and coil propensity represent structures of amyloids and aid in elucidating phenomena involved in interspecies transmission of prions.PrPSc formation and clearance as determinants of prion tropism.
P2860
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P2860
Isolation of phosphatidylethanolamine as a solitary cofactor for prion formation in the absence of nucleic acids
description
2012 nî lūn-bûn
@nan
2012 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Isolation of phosphatidylethan ...... n the absence of nucleic acids
@ast
Isolation of phosphatidylethan ...... n the absence of nucleic acids
@en
Isolation of phosphatidylethan ...... n the absence of nucleic acids
@nl
type
label
Isolation of phosphatidylethan ...... n the absence of nucleic acids
@ast
Isolation of phosphatidylethan ...... n the absence of nucleic acids
@en
Isolation of phosphatidylethan ...... n the absence of nucleic acids
@nl
prefLabel
Isolation of phosphatidylethan ...... n the absence of nucleic acids
@ast
Isolation of phosphatidylethan ...... n the absence of nucleic acids
@en
Isolation of phosphatidylethan ...... n the absence of nucleic acids
@nl
P2093
P2860
P3181
P356
P1476
Isolation of phosphatidylethan ...... n the absence of nucleic acids
@en
P2093
Daniel J Walsh
James C Geoghegan
Nathan R Deleault
Surachai Supattapone
P2860
P304
P3181
P356
10.1073/PNAS.1204498109
P407
P577
2012-05-14T00:00:00Z