Lrp5 functions in bone to regulate bone mass - Wikidata - wikimedia - TriplyDB

Lrp5 functions in bone to regulate bone mass

Lrp5 functions in bone to regulate bone mass

http://www.wikidata.org/entity/Q24615653

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Inactivation of Lrp5 in osteocytes reduces young's modulus and responsiveness to the mechanical loading Low-density lipoprotein receptor (LDLR) family orchestrates cholesterol homeostasis FOXO1 orchestrates the bone-suppressing function of gut-derived serotonin 5-Hydroxytryptamine (serotonin) in the gastrointestinal tract Nuclear receptors in bone physiology and diseases In vitro and in vivo approaches to study osteocyte biology Bone collagen: new clues to its mineralization mechanism from recessive osteogenesis imperfecta WNT signaling in bone development and homeostasis Regulation of bone-renal mineral and energy metabolism: the PHEX, FGF23, DMP1, MEPE ASARM pathway The DNA helicase recql4 is required for normal osteoblast expansion and osteosarcoma formation Critical Endothelial Regulation by LRP5 during Retinal Vascular Development A unified model for bone-renal mineral and energy metabolism LRP5 and LRP6 in development and disease The Bone Marrow-Derived Stromal Cells: Commitment and Regulation of Adipogenesis Potential role for therapies targeting DKK1, LRP5, and serotonin in the treatment of osteoporosis WNT signaling in bone homeostasis and disease: from human mutations to treatments Regulation of Wnt/β-catenin signaling within and from osteocytes Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation Lrp5 and Lrp6 exert overlapping functions in osteoblasts during postnatal bone acquisition Single-pulsed electromagnetic field therapy increases osteogenic differentiation through Wnt signaling pathway and sclerostin downregulation.Wnt-Lrp5 signaling regulates fatty acid metabolism in the osteoblast.Guidelines for Dual Energy X-Ray Absorptiometry Analysis of Trabecular Bone-Rich Regions in Mice: Improved Precision, Accuracy, and Sensitivity for Assessing Longitudinal Bone Changes Transcriptomic Changes in Coral Holobionts Provide Insights into Physiological Challenges of Future Climate and Ocean Change.PHEX mimetic (SPR4-peptide) corrects and improves HYP and wild type mice energy-metabolism Wise regulates bone deposition through genetic interactions with Lrp5 Canonical Wnt signalling activates TAZ through PP1A during osteogenic differentiation.Activation of Wnt Signaling by Mechanical Loading Is Impaired in the Bone of Old Mice Dioscin promotes osteoblastic proliferation and differentiation via Lrp5 and ER pathway in mouse and human osteoblast-like cell lines.Parathyroid hormone: anabolic and catabolic actions on the skeleton Wnts' fashion statement: from body stature to dysplasia.The swaying mouse as a model of osteogenesis imperfecta caused by WNT1 mutations The best of both worlds - managing the cancer, saving the bone.Osteocyte-Secreted Wnt Signaling Inhibitor Sclerostin Contributes to Beige Adipogenesis in Peripheral Fat Depots.Serotonergic Mechanisms Regulating the GI Tract: Experimental Evidence and Therapeutic Relevance Osteoblast-specific Krm2 overexpression and Lrp5 deficiency have different effects on fracture healing in mice.Targeting the LRP5 pathway improves bone properties in a mouse model of osteogenesis imperfecta.Serotonin regulates osteoblast proliferation and function in vitro.Mutations in LRP5 cause primary osteoporosis without features of OI by reducing Wnt signaling activity.Wnt5a can both activate and repress Wnt/β-catenin signaling during mouse embryonic development.Wnt coreceptor Lrp5 is a driver of idiopathic pulmonary fibrosis.

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P2860

Lrp5 functions in bone to regulate bone mass

http://www.wikidata.org/entity/Q24615653

description

2011 nî lūn-bûn

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2011 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հունիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Lrp5 functions in bone to regulate bone mass

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Lrp5 functions in bone to regulate bone mass

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Lrp5 functions in bone to regulate bone mass

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type

label

Lrp5 functions in bone to regulate bone mass

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Lrp5 functions in bone to regulate bone mass

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Lrp5 functions in bone to regulate bone mass

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prefLabel

Lrp5 functions in bone to regulate bone mass

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Lrp5 functions in bone to regulate bone mass

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Lrp5 functions in bone to regulate bone mass

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Nature Medicine

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Lrp5 functions in bone to regulate bone mass

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Alexander G Robling

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Bart O Williams

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Brian Zambrowicz

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Bryan T MacDonald

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Cassandra R Zylstra

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Christina M Jacobsen

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Daniel R Robinson

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David R Powell

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Faika Mseeh

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Han Gerrits

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P2860

Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants.

Molecular cloning and characterization of LR3, a novel LDL receptor family protein with mitogenic activity

Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density

Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein

A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis

Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum

Growth retardation and altered autonomic control in mice lacking brain serotonin

High bone mass in mice expressing a mutant LRP5 gene

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10.1038/NM.2388

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6

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1044848736

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21602802

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3113461

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