Synthesis of quinoline derivatives: discovery of a potent and selective phosphodiesterase 5 inhibitor for the treatment of Alzheimer's disease - Wikidata - wikimedia - TriplyDB

Synthesis of quinoline derivatives: discovery of a potent and selective phosphodiesterase 5 inhibitor for the treatment of Alzheimer's disease

Synthesis of quinoline derivatives: discovery of a potent and selective phosphodiesterase 5 inhibitor for the treatment of Alzheimer's disease

http://www.wikidata.org/entity/Q24615907

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Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition Behavioral assays with mouse models of Alzheimer's disease: practical considerations and guidelines.Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction Pharmacological Modulation of Functional Phenotypes of Microglia in Neurodegenerative Diseases Synaptic therapy in Alzheimer's disease: a CREB-centric approach.Synthesis and SAR studies of novel 6,7,8-substituted 4-substituted benzyloxyquinolin-2(1H)-one derivatives for anticancer activity Rodent models for Alzheimer's disease drug discovery.PP2A methylation controls sensitivity and resistance to β-amyloid-induced cognitive and electrophysiological impairments.Development of a New Radiofluorinated Quinoline Analog for PET Imaging of Phosphodiesterase 5 (PDE5) in Brain.Modulating nitric oxide signaling in the CNS for Alzheimer's disease therapy.Recent advances in research of natural and synthetic bioactive quinolines.Novel Selective Calpain 1 Inhibitors as Potential Therapeutics in Alzheimer's Disease.LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent.Icariside II, a novel phosphodiesterase 5 inhibitor, protects against H2 O2 -induced PC12 cells death by inhibiting mitochondria-mediated autophagy Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory.Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain.Troxerutin protects hippocampal neurons against amyloid beta-induced oxidative stress and apoptosis.A novel synthetic phosphodiesterase 5 inhibitor, KJH-1002, ameliorates scopolamine-induced cognitive impairments in mice by activating the cGMP/CREB signaling pathway and attenuating oxidative damage.Translational inhibition of APP by Posiphen: Efficacy, pharmacodynamics, and pharmacokinetics in the APP/PS1 mouse.

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Synthesis of quinoline derivatives: discovery of a potent and selective phosphodiesterase 5 inhibitor for the treatment of Alzheimer's disease

http://www.wikidata.org/entity/Q24615907

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2013 nî lūn-bûn

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2013 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2013 թվականի փետրվարին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Synthesis of quinoline derivat ...... eatment of Alzheimer's disease

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Synthesis of quinoline derivat ...... eatment of Alzheimer's disease

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Synthesis of quinoline derivat ...... eatment of Alzheimer's disease

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Synthesis of quinoline derivat ...... eatment of Alzheimer's disease

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Synthesis of quinoline derivat ...... eatment of Alzheimer's disease

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Synthesis of quinoline derivat ...... eatment of Alzheimer's disease

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Synthesis of quinoline derivat ...... eatment of Alzheimer's disease

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Synthesis of quinoline derivat ...... eatment of Alzheimer's disease

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J.EJMECH.2012.12.009

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European Journal of Medicinal Chemistry

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Synthesis of quinoline derivat ...... eatment of Alzheimer's disease

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Agnieszka Staniszewski

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Devarshi M Thakkar

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Donald W Landry

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Faisal Saeed

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Hong Zhang

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Shi-Xian Deng

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Sudha Rao

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Yan Feng

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Yitshak I Francis

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P2860

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms

4-(3-Chloro-4-methoxybenzyl)aminophthalazines: synthesis and inhibitory activity toward phosphodiesterase 5.

Sildenafil for pulmonary hypertension.

Medicinal chemical properties of successful central nervous system drugs

Substituted pyrazolopyridopyridazines as orally bioavailable potent and selective PDE5 inhibitors: potential agents for treatment of erectile dysfunction.

Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling

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285-94

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scholarly article

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10.1016/J.EJMECH.2012.12.009

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60

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Ottavio Arancio

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2013-02-01T00:00:00Z

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23313637

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Alzheimer's disease

Aagianik kimischri

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3582828

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