APOBEC3G contributes to HIV-1 variation through sublethal mutagenesis - Wikidata - wikimedia - TriplyDB

APOBEC3G contributes to HIV-1 variation through sublethal mutagenesis

APOBEC3G contributes to HIV-1 variation through sublethal mutagenesis

http://www.wikidata.org/entity/Q24618320

about

AID and APOBECs span the gap between innate and adaptive immunity Differential anti-APOBEC3G activity of HIV-1 Vif proteins derived from different subtypes First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them all Evolution of foamy viruses: the most ancient of all retroviruses Viral quasispecies evolution Suppression of APOBEC3-mediated restriction of HIV-1 by Vif The role of innate APOBEC3G and adaptive AID immune responses in HLA-HIV/SIV immunized SHIV infected macaques Mechanisms of viral mutation Different mutagenic potential of HIV-1 restriction factors APOBEC3G and APOBEC3F is determined by distinct single-stranded DNA scanning mechanisms Extremely High Mutation Rate of HIV-1 In Vivo Human immunodeficiency virus reverse transcriptase displays dramatically higher fidelity under physiological magnesium conditions in vitro.Human APOBEC3G-mediated editing can promote HIV-1 sequence diversification and accelerate adaptation to selective pressure.Long-term restriction by APOBEC3F selects human immunodeficiency virus type 1 variants with restored Vif function APOBEC3G-induced hypermutation of human immunodeficiency virus type-1 is typically a discrete "all or nothing" phenomenon.Retroviral vectors for analysis of viral mutagenesis and recombination.Local sequence targeting in the AID/APOBEC family differentially impacts retroviral restriction and antibody diversification.Small-molecule APOBEC3G DNA cytosine deaminase inhibitors based on a 4-amino-1,2,4-triazole-3-thiol scaffold.HIV restriction by APOBEC3 in humanized mice.Codon pairs of the HIV-1 vif gene correlate with CD4+ T cell count Intensity of deoxycytidine deamination of HIV-1 proviral DNA by the retroviral restriction factor APOBEC3G is mediated by the noncatalytic domain.Uracil DNA glycosylase counteracts APOBEC3G-induced hypermutation of hepatitis B viral genomes: excision repair of covalently closed circular DNA.APOBEC3G-Augmented Stem Cell Therapy to Modulate HIV Replication: A Computational Study.APOBEC3G: a double agent in defense Ex vivo gene therapy for HIV-1 treatment.Intercompartmental recombination of HIV-1 contributes to env intrahost diversity and modulates viral tropism and sensitivity to entry inhibitors Multifaceted counter-APOBEC3G mechanisms employed by HIV-1 Vif.TRIM5α restriction affects clinical outcome and disease progression in simian immunodeficiency virus-infected rhesus macaques Positioning of APOBEC3G/F mutational hotspots in the human immunodeficiency virus genome favors reduced recognition by CD8+ T cells APOBEC3 has not left an evolutionary footprint on the HIV-1 genome.Target cell-mediated editing of HIV-1 cDNA by APOBEC3 proteins in human macrophages.The HDAC6/APOBEC3G complex regulates HIV-1 infectiveness by inducing Vif autophagic degradation.Interferon-α Subtypes in an Ex Vivo Model of Acute HIV-1 Infection: Expression, Potency and Effector Mechanisms HIV-1 and HIV-2 exhibit similar mutation frequencies and spectra in the absence of G-to-A hypermutation.Hypermutation of ApoB mRNA by rat APOBEC-1 overexpression mimics APOBEC-3 hypermutation.Incomplete APOBEC3G/F Neutralization by HIV-1 Vif Mutants Facilitates the Genetic Evolution from CCR5 to CXCR4 Usage.HIV Restriction Factors and Mechanisms of Evasion.Role of APOBEC3F Gene Variation in HIV-1 Disease Progression and Pneumocystis Pneumonia.Interplay between HIV-1 and Host Genetic Variation: A Snapshot into Its Impact on AIDS and Therapy Response.APOBEC3G expression and hypermutation are inversely associated with human immunodeficiency virus type 1 (HIV-1) burden in vivo.

P2860

Q21131084-66594BB7-AD21-43B7-A3E6-1E95E474F76C Q24612992-AA7C6036-296B-4220-895C-FDB1DB98CF95 Q24615552-0FA057EE-A1A4-4B28-896E-FB5E803344DF Q26823568-4D8EA98B-43D5-47C4-8463-2E359D0ABD10 Q26852372-64214CAF-092B-474E-929E-F3243C2B74AE Q27013917-E2709319-3DB9-4F27-82E2-AFCA1613CF28 Q27025150-27C91FC5-8F9A-4B08-B79C-B7F4D232AA6F Q27305204-6FBD0240-0D77-4169-9AE4-4587F608D29D Q28067235-0070A70E-A317-416A-BD4C-D39787850DC0 Q28541264-1E90E7F6-028C-4B72-8E5F-AE34E1C799A6 Q28548089-1B357923-A6DE-4425-ABF3-479065981F0E Q34057801-AA1E3F82-0560-405A-AB54-16519581D53E Q34120736-A54056A3-8BC7-4C76-A7DC-C8056E1AD039 Q34120768-BF6134A4-5E48-4DC2-92E2-6BB8CC26B76D Q34211562-E11B30F9-F15F-4F0B-8C05-433D90E9A7BE Q34303615-044E1F44-8327-4D97-BA35-F68BB1A2CFBD Q34412763-98737918-98C1-41D6-BABA-FAAEDD65A95A Q34488163-EF070716-D6CC-4AB0-8F5A-89E4279C9C51 Q34649651-023E02D0-6760-47A0-826E-AE008F8AF859 Q34665129-5FA9443F-C26D-4C25-9E9F-EB9D3CB60638 Q34719668-629F7C90-9FB0-4D0E-92E9-05D12C784E3F Q34733579-F548C072-E2FC-4E86-AFF5-FEADA6A78C12 Q34749384-BBF0B80E-00BE-46FE-9FD3-0287C4392BE6 Q34917194-71E64189-8A56-4C62-A294-DA54CC40C447 Q34982851-D818E10B-9232-406C-94DE-5AAD561B504E Q35076953-F957DD15-D358-4143-A8B6-75D84AA37F90 Q35113622-B3128F16-C6D9-43F0-B70E-F0D1D841E6A8 Q35115622-3F9DC6D5-1EC5-4080-8DC1-552462B614AC Q35145382-81CB5E55-E7E0-41ED-94B4-FF6C88CF5B3B Q35192791-7F1A000B-5C9A-4876-B430-9ECDE78900AF Q35599400-A8763DB7-EC10-4EA4-9B01-C8C80BD9D580 Q35776289-8F511DB9-2887-41EA-A9DE-5B64F2575C7A Q35830651-3740396E-4CFE-41E9-A8BE-74AEE55BD075 Q35834559-25F066D1-D657-4016-8A58-C4439A0A2774 Q35850930-75C384D3-0BAF-4BBF-B71E-1FB8A0C9865F Q35859926-523E8035-BE18-46E7-B8A8-277794C137C2 Q35902681-91FD6A3D-2CBC-4299-88B1-6D8D27FB8127 Q35945852-2C4F15BF-87E7-4A4E-B0CF-B182E4F7F396 Q35993707-11E70031-480F-4DCE-A93A-493DD9DDEBB3 Q36019696-50B2DF9F-1BFF-4B1D-A893-C9892CF97960

P2860

APOBEC3G contributes to HIV-1 variation through sublethal mutagenesis

http://www.wikidata.org/entity/Q24618320

description

2010 nî lūn-bûn

@nan

2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

APOBEC3G contributes to HIV-1 variation through sublethal mutagenesis

@ast

APOBEC3G contributes to HIV-1 variation through sublethal mutagenesis

@en

APOBEC3G contributes to HIV-1 variation through sublethal mutagenesis

@nl

type

label

APOBEC3G contributes to HIV-1 variation through sublethal mutagenesis

@ast

APOBEC3G contributes to HIV-1 variation through sublethal mutagenesis

@en

APOBEC3G contributes to HIV-1 variation through sublethal mutagenesis

@nl

prefLabel

APOBEC3G contributes to HIV-1 variation through sublethal mutagenesis

@ast

APOBEC3G contributes to HIV-1 variation through sublethal mutagenesis

@en

APOBEC3G contributes to HIV-1 variation through sublethal mutagenesis

@nl

P1433

Q24618320-5AEA0A1B-18AD-4A66-AB27-4E24BE022598

P1476

Q24618320-9D3E2B7A-E67D-4AA2-9D3A-CE199C655251

P2093

Q24618320-1D90B817-6FB3-488E-BE74-848AA77639EB

Q24618320-CFA38A90-90A7-4356-BE51-BFF1102A2965

Q24618320-F6BE6B21-A09F-4388-B086-9DD6C8941C0F

P2860

Q24618320-000F9757-9FB9-496A-8C07-972D0240B909

Q24618320-021E9258-7A4A-448A-8D51-E435317A0D67

Q24618320-06976120-FA81-43CE-80E7-94B6588B03AC

Q24618320-06FF9131-5BF8-40C7-B560-2F9D355D8F97

Q24618320-0824F43E-F3D8-46B0-A5A1-CBFD70C323F3

Q24618320-14F5B56D-BD2D-4835-89F2-CAEB767DF7C8

Q24618320-15896F47-A2DD-4A3A-AB7C-2B5A6CEA1EF3

Q24618320-17BF321D-A1D9-4ABF-AE7F-B026D06338AC

Q24618320-1A5FBD19-BB3B-4F3F-8C1B-DB7018211E79

Q24618320-1CA68013-77BD-40AE-9462-4652136DFDDA

P304

Q24618320-D905A675-9C5E-4ABD-A546-8187D01727A5

P31

Q24618320-2896E0FA-F2E8-4922-8A6F-79FE098F6303

P3181

Q24618320-1971A1CA-7564-41F2-9E47-362DC752538E

P356

Q24618320-C13362C3-3914-47EC-A2C3-DD18395B31C4

P407

Q24618320-40A1981A-A44D-41C6-BB02-70E99F0C5017

P433

Q24618320-DBF1B547-F2E2-4A41-972F-CBEF1C68039F

P478

Q24618320-B11C8656-A086-4483-A0F4-EBDE83DAC4DD

P50

Q24618320-603ABC30-F9F9-43F6-B244-79B9A5DAA6D5

P577

Q24618320-5FDE441B-63AB-4C85-99BE-173C3059B941

P5875

Q24618320-520A9F6C-61FC-4458-BBC6-EB63C93C339B

P698

Q24618320-8A7DC3F2-4358-41D0-89B5-433D22CC3B2D

P932

Q24618320-2250DF70-DB76-4005-BD15-6DE3669D964E

P3181

P356

P1433

Journal of Virology

P1476

APOBEC3G contributes to HIV-1 variation through sublethal mutagenesis

@en

P2093

Holly A Sadler

http://www.w3.org/2001/XMLSchema#string

Louis M Mansky

http://www.w3.org/2001/XMLSchema#string

Mark D Stenglein

http://www.w3.org/2001/XMLSchema#string

P2860

The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA

APOBEC3F can inhibit the accumulation of HIV-1 reverse transcription products in the absence of hypermutation. Comparisons with APOBEC3G

HIV-1 Vif, APOBEC, and intrinsic immunity

Cytidine deamination induced HIV-1 drug resistance

Inhibition of tRNA₃(Lys)-primed reverse transcription by human APOBEC3G during human immunodeficiency virus type 1 replication

Human immunodeficiency virus type 1 cDNAs produced in the presence of APOBEC3G exhibit defects in plus-strand DNA transfer and integration

Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity

Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein

Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts

DNA deamination mediates innate immunity to retroviral infection

P304

7396-404

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

1596948

http://www.w3.org/2001/XMLSchema#string

P356

10.1128/JVI.00056-10

http://www.w3.org/2001/XMLSchema#string

P407

P433

14

http://www.w3.org/2001/XMLSchema#string

P478

84

http://www.w3.org/2001/XMLSchema#string

P50

Reuben S Harris

P577

2010-07-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

44592683

http://www.w3.org/2001/XMLSchema#string

P698

20463080

http://www.w3.org/2001/XMLSchema#string

P932

2898230

http://www.w3.org/2001/XMLSchema#string