Structural insight into KCNQ (Kv7) channel assembly and channelopathy - Wikidata - wikimedia - TriplyDB

Structural insight into KCNQ (Kv7) channel assembly and channelopathy

Structural insight into KCNQ (Kv7) channel assembly and channelopathy

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Ion channel clustering at the axon initial segment and node of Ranvier evolved sequentially in early chordates Analysis of the interactions between the C-terminal cytoplasmic domains of KCNQ1 and KCNE1 channel subunits The KCNQ1 (Kv7.1) COOH terminus, a multitiered scaffold for subunit assembly and protein interaction Cellular mechanisms of mutations in Kv7.1: auditory functions in Jervell and Lange-Nielsen syndrome vs. Romano-Ward syndrome Intracellular domains interactions and gated motions of I(KS) potassium channel subunits Ion channels as drug targets in central nervous system disorders Structure of thermally activated TRP channels Driving with no brakes: molecular pathophysiology of Kv7 potassium channels Structure of KCNE1 and Implications for How It Modulates the KCNQ1 Potassium Channel † ‡X-ray Crystal Structure of a TRPM Assembly Domain Reveals an Antiparallel Four-stranded Coiled-coil Crystal structure of a trimeric form of the KV7.1 (KCNQ1) A-domain tail coiled-coil reveals structural plasticity and context dependent changes in a putative coiled-coil trimerization motif Molecular mechanism for 3:1 subunit stoichiometry of rod cyclic nucleotide-gated ion channels Gating of the designed trimeric/tetrameric voltage-gated H+channel Structure of a Ca2+/CaM:Kv7.4 (KCNQ4) B-Helix Complex Provides Insight into M Current Modulation The C-terminal helical bundle of the tetrameric prokaryotic sodium channel accelerates the inactivation rate Role of the C-terminal domain in the structure and function of tetrameric sodium channels.Structure of a Prokaryotic Sodium Channel Pore Reveals Essential Gating Elements and an Outer Ion Binding Site Common to Eukaryotic Channels Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC)Parallel evolution of KCNQ4 in echolocating bats Structure of a 13-fold superhelix (almost) determined from first principles.Routine phasing of coiled-coil protein crystal structures with AMPLE Probing designability via a generalized model of helical bundle geometry Structural characteristics of the redox-sensing coiled coil in the voltage-gated H+ channel.Kcnq1-5 (Kv7.1-5) potassium channel expression in the adult zebrafish.Determinants within the turret and pore-loop domains of KCNQ3 K+ channels governing functional activity.Homomeric and heteromeric assembly of KCNQ (Kv7) K+ channels assayed by total internal reflection fluorescence/fluorescence resonance energy transfer and patch clamp analysis.Direct observation of individual KCNQ1 potassium channels reveals their distinctive diffusive behavior.Working model for the structural basis for KCNE1 modulation of the KCNQ1 potassium channel.Functional study of the effect of phosphatase inhibitors on KCNQ4 channels expressed in Xenopus oocytes Oxidative modulation of voltage-gated potassium channels.Kv7-type channel currents in spiral ganglion neurons: involvement in sensorineural hearing loss.Made for "anchorin": Kv7.2/7.3 (KCNQ2/KCNQ3) channels and the modulation of neuronal excitability in vertebrate axons.Bacterial voltage-gated sodium channels (BacNa(V)s) from the soil, sea, and salt lakes enlighten molecular mechanisms of electrical signaling and pharmacology in the brain and heart.GCN4 enhances the stability of the pore domain of potassium channel KcsA.Effects of KCNQ2 gene truncation on M-type Kv7 potassium currents LQT1 mutations in KCNQ1 C-terminus assembly domain suppress IKs using different mechanisms.Major diversification of voltage-gated K+ channels occurred in ancestral parahoxozoans.Molecular microdomains in a sensory terminal, the vestibular calyx ending An Ankyrin-G N-terminal Gate and Protein Kinase CK2 Dually Regulate Binding of Voltage-gated Sodium and KCNQ2/3 Potassium Channels The Role of the Carboxyl Terminus Helix C-D Linker in Regulating KCNQ3 K+ Current Amplitudes by Controlling Channel Trafficking

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Structural insight into KCNQ (Kv7) channel assembly and channelopathy

http://www.wikidata.org/entity/Q24619681

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2007 nî lūn-bûn

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2007 թուականի Մարտին հրատարակուած գիտական յօդուած

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2007 թվականի մարտին հրատարակված գիտական հոդված

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2007年の論文

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2007年学术文章

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2007年學術文章

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Structural insight into KCNQ (Kv7) channel assembly and channelopathy

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Structural insight into KCNQ (Kv7) channel assembly and channelopathy

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Structural insight into KCNQ (Kv7) channel assembly and channelopathy

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Structural insight into KCNQ (Kv7) channel assembly and channelopathy

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Structural insight into KCNQ (Kv7) channel assembly and channelopathy

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Structural insight into KCNQ (Kv7) channel assembly and channelopathy

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Structural Insight into KCNQ (Kv7) Channel Assembly and Channelopathy

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Structural insight into KCNQ (Kv7) channel assembly and channelopathy

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Structural insight into KCNQ (Kv7) channel assembly and channelopathy

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Structural insight into KCNQ (Kv7) channel assembly and channelopathy

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J.NEURON.2007.02.010

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Structural insight into KCNQ (Kv7) channel assembly and channelopathy

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Daniel L Minor

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James M Holton

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Kimberly A Clark

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Rebecca J Howard

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P2860

KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel

KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness

Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity

Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel

Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel

A carboxy-terminal domain determines the subunit specificity of KCNQ K+ channel assembly.

The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry

Inhibition of KCNQ1-4 potassium channels expressed in mammalian cells via M1 muscarinic acetylcholine receptors

SWISS-MODEL: An automated protein homology-modeling server

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